POTENTIATION OF ANTIHYPERTENSIVE EFFECT OF ACE INHIBITORS
Est décrit un procédé pour exhalter l'effet anti-hypertensif d'un inhibiteur de l'enzyme de conversion de l'angiotensine, consistant à administrer à des mammifères une quantité potentialisante anti-hypertensive efficace de 1-méthyl-2-(3-pyridyl)-3-(5-carboxypentyl)-5-chloroindole...
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| creator | KSANDER, GARY, M ZIMMERMAN, MARK, B |
| description | Est décrit un procédé pour exhalter l'effet anti-hypertensif d'un inhibiteur de l'enzyme de conversion de l'angiotensine, consistant à administrer à des mammifères une quantité potentialisante anti-hypertensive efficace de 1-méthyl-2-(3-pyridyl)-3-(5-carboxypentyl)-5-chloroindole, ou son sel pharmaceutiquement acceptable. Sont également décrites des compositions pharmaceutiques renfermant le dérivé de 2-(3-pyridyl)-indole en combinaison avec un inhibiteur de l'enzyme de conversion de l'angiotensine.
Disclosed is a method of enhancing the antihypertensive effect of an angiotensin converting enzyme inhibitor which comprises the administration to mammals of an effective antihypertensive potentiating amount of 1-(7-carboxyheptyl)-3-methyl-2-(3-pyridyl)-indole, 1-methyl-2-(3-pyridyl)-3-)5-carboxypentyl)-5-chloroindole, or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions comprising the 2-(3-pyridyl)-indole derivatie in combination with an angiotensin converting enzyme inhibitor. |
| format | Patent |
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Disclosed is a method of enhancing the antihypertensive effect of an angiotensin converting enzyme inhibitor which comprises the administration to mammals of an effective antihypertensive potentiating amount of 1-(7-carboxyheptyl)-3-methyl-2-(3-pyridyl)-indole, 1-methyl-2-(3-pyridyl)-3-)5-carboxypentyl)-5-chloroindole, or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions comprising the 2-(3-pyridyl)-indole derivatie in combination with an angiotensin converting enzyme inhibitor.</description><language>eng ; fre ; ger</language><subject>HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1989</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19891018&DB=EPODOC&CC=EP&NR=0336950A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,778,883,25547,76298</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19891018&DB=EPODOC&CC=EP&NR=0336950A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KSANDER, GARY, M</creatorcontrib><creatorcontrib>ZIMMERMAN, MARK, B</creatorcontrib><title>POTENTIATION OF ANTIHYPERTENSIVE EFFECT OF ACE INHIBITORS</title><description>Est décrit un procédé pour exhalter l'effet anti-hypertensif d'un inhibiteur de l'enzyme de conversion de l'angiotensine, consistant à administrer à des mammifères une quantité potentialisante anti-hypertensive efficace de 1-méthyl-2-(3-pyridyl)-3-(5-carboxypentyl)-5-chloroindole, ou son sel pharmaceutiquement acceptable. Sont également décrites des compositions pharmaceutiques renfermant le dérivé de 2-(3-pyridyl)-indole en combinaison avec un inhibiteur de l'enzyme de conversion de l'angiotensine.
Disclosed is a method of enhancing the antihypertensive effect of an angiotensin converting enzyme inhibitor which comprises the administration to mammals of an effective antihypertensive potentiating amount of 1-(7-carboxyheptyl)-3-methyl-2-(3-pyridyl)-indole, 1-methyl-2-(3-pyridyl)-3-)5-carboxypentyl)-5-chloroindole, or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions comprising the 2-(3-pyridyl)-indole derivatie in combination with an angiotensin converting enzyme inhibitor.</description><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1989</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAM8A9x9QvxdAzx9PdT8HdTcARyPCIDXIOAwsGeYa4Krm5urs4hYClnVwVPPw9PJ88Q_6BgHgbWtMSc4lReKM3NoODmGuLsoZtakB-fWlyQmJyal1oS7xpgYGxsZmlq4GhoTIQSAFnbKIc</recordid><startdate>19891018</startdate><enddate>19891018</enddate><creator>KSANDER, GARY, M</creator><creator>ZIMMERMAN, MARK, B</creator><scope>EVB</scope></search><sort><creationdate>19891018</creationdate><title>POTENTIATION OF ANTIHYPERTENSIVE EFFECT OF ACE INHIBITORS</title><author>KSANDER, GARY, M ; ZIMMERMAN, MARK, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP0336950A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>1989</creationdate><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>KSANDER, GARY, M</creatorcontrib><creatorcontrib>ZIMMERMAN, MARK, B</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KSANDER, GARY, M</au><au>ZIMMERMAN, MARK, B</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>POTENTIATION OF ANTIHYPERTENSIVE EFFECT OF ACE INHIBITORS</title><date>1989-10-18</date><risdate>1989</risdate><abstract>Est décrit un procédé pour exhalter l'effet anti-hypertensif d'un inhibiteur de l'enzyme de conversion de l'angiotensine, consistant à administrer à des mammifères une quantité potentialisante anti-hypertensive efficace de 1-méthyl-2-(3-pyridyl)-3-(5-carboxypentyl)-5-chloroindole, ou son sel pharmaceutiquement acceptable. Sont également décrites des compositions pharmaceutiques renfermant le dérivé de 2-(3-pyridyl)-indole en combinaison avec un inhibiteur de l'enzyme de conversion de l'angiotensine.
Disclosed is a method of enhancing the antihypertensive effect of an angiotensin converting enzyme inhibitor which comprises the administration to mammals of an effective antihypertensive potentiating amount of 1-(7-carboxyheptyl)-3-methyl-2-(3-pyridyl)-indole, 1-methyl-2-(3-pyridyl)-3-)5-carboxypentyl)-5-chloroindole, or a pharmaceutically acceptable salt thereof. Also disclosed are pharmaceutical compositions comprising the 2-(3-pyridyl)-indole derivatie in combination with an angiotensin converting enzyme inhibitor.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | POTENTIATION OF ANTIHYPERTENSIVE EFFECT OF ACE INHIBITORS |
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