ANTIMERS AND ANTIMERIC CONJUGATION
There is disclosed an antibody and antibody-drug conjugate for targeting drug delivery as well as a class of chemicals, termed an "antimer." The antimer is designed to "fit" the drug by combining multiple non-covalent interactions between functional groups on the drug and opposin...
Gespeichert in:
| Hauptverfasser: | , , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | PRIEST, JOHN H MORGAN, ALTON C., JR FRITZBERG, ALAN R ANDERSON, DAVID C ABRAMS, PAUL G RENO, JOHN M SIVAM, GOWSALA P SRINIVASAN, ANANTHACHARI |
| description | There is disclosed an antibody and antibody-drug conjugate for targeting drug delivery as well as a class of chemicals, termed an "antimer." The antimer is designed to "fit" the drug by combining multiple non-covalent interactions between functional groups on the drug and opposing functional groups on the antimer. The net result on the antibody-antimer-drug conjugate is a drug stably bound to the antimer so as not to dissociate during in vivo administration, but not so tightly bound to allow drug dissociation from the conjugate without significant loss of activity and retaining the drug's ability to bind to a higher affinity site on the or within the target cell. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP0329184A3</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP0329184A3</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP0329184A33</originalsourceid><addsrcrecordid>eNrjZFBy9Avx9HUNClZw9HNRgHI8nRWc_f28Qt0dQzz9_XgYWNMSc4pTeaE0N4OCm2uIs4duakF-fGpxQWJyal5qSbxrgIGxkaWhhYmjsTERSgD68SIe</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>ANTIMERS AND ANTIMERIC CONJUGATION</title><source>esp@cenet</source><creator>PRIEST, JOHN H ; MORGAN, ALTON C., JR ; FRITZBERG, ALAN R ; ANDERSON, DAVID C ; ABRAMS, PAUL G ; RENO, JOHN M ; SIVAM, GOWSALA P ; SRINIVASAN, ANANTHACHARI</creator><creatorcontrib>PRIEST, JOHN H ; MORGAN, ALTON C., JR ; FRITZBERG, ALAN R ; ANDERSON, DAVID C ; ABRAMS, PAUL G ; RENO, JOHN M ; SIVAM, GOWSALA P ; SRINIVASAN, ANANTHACHARI</creatorcontrib><description>There is disclosed an antibody and antibody-drug conjugate for targeting drug delivery as well as a class of chemicals, termed an "antimer." The antimer is designed to "fit" the drug by combining multiple non-covalent interactions between functional groups on the drug and opposing functional groups on the antimer. The net result on the antibody-antimer-drug conjugate is a drug stably bound to the antimer so as not to dissociate during in vivo administration, but not so tightly bound to allow drug dissociation from the conjugate without significant loss of activity and retaining the drug's ability to bind to a higher affinity site on the or within the target cell.</description><edition>4</edition><language>eng</language><subject>CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1990</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19900523&DB=EPODOC&CC=EP&NR=0329184A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19900523&DB=EPODOC&CC=EP&NR=0329184A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PRIEST, JOHN H</creatorcontrib><creatorcontrib>MORGAN, ALTON C., JR</creatorcontrib><creatorcontrib>FRITZBERG, ALAN R</creatorcontrib><creatorcontrib>ANDERSON, DAVID C</creatorcontrib><creatorcontrib>ABRAMS, PAUL G</creatorcontrib><creatorcontrib>RENO, JOHN M</creatorcontrib><creatorcontrib>SIVAM, GOWSALA P</creatorcontrib><creatorcontrib>SRINIVASAN, ANANTHACHARI</creatorcontrib><title>ANTIMERS AND ANTIMERIC CONJUGATION</title><description>There is disclosed an antibody and antibody-drug conjugate for targeting drug delivery as well as a class of chemicals, termed an "antimer." The antimer is designed to "fit" the drug by combining multiple non-covalent interactions between functional groups on the drug and opposing functional groups on the antimer. The net result on the antibody-antimer-drug conjugate is a drug stably bound to the antimer so as not to dissociate during in vivo administration, but not so tightly bound to allow drug dissociation from the conjugate without significant loss of activity and retaining the drug's ability to bind to a higher affinity site on the or within the target cell.</description><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1990</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFBy9Avx9HUNClZw9HNRgHI8nRWc_f28Qt0dQzz9_XgYWNMSc4pTeaE0N4OCm2uIs4duakF-fGpxQWJyal5qSbxrgIGxkaWhhYmjsTERSgD68SIe</recordid><startdate>19900523</startdate><enddate>19900523</enddate><creator>PRIEST, JOHN H</creator><creator>MORGAN, ALTON C., JR</creator><creator>FRITZBERG, ALAN R</creator><creator>ANDERSON, DAVID C</creator><creator>ABRAMS, PAUL G</creator><creator>RENO, JOHN M</creator><creator>SIVAM, GOWSALA P</creator><creator>SRINIVASAN, ANANTHACHARI</creator><scope>EVB</scope></search><sort><creationdate>19900523</creationdate><title>ANTIMERS AND ANTIMERIC CONJUGATION</title><author>PRIEST, JOHN H ; MORGAN, ALTON C., JR ; FRITZBERG, ALAN R ; ANDERSON, DAVID C ; ABRAMS, PAUL G ; RENO, JOHN M ; SIVAM, GOWSALA P ; SRINIVASAN, ANANTHACHARI</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP0329184A33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1990</creationdate><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>PRIEST, JOHN H</creatorcontrib><creatorcontrib>MORGAN, ALTON C., JR</creatorcontrib><creatorcontrib>FRITZBERG, ALAN R</creatorcontrib><creatorcontrib>ANDERSON, DAVID C</creatorcontrib><creatorcontrib>ABRAMS, PAUL G</creatorcontrib><creatorcontrib>RENO, JOHN M</creatorcontrib><creatorcontrib>SIVAM, GOWSALA P</creatorcontrib><creatorcontrib>SRINIVASAN, ANANTHACHARI</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PRIEST, JOHN H</au><au>MORGAN, ALTON C., JR</au><au>FRITZBERG, ALAN R</au><au>ANDERSON, DAVID C</au><au>ABRAMS, PAUL G</au><au>RENO, JOHN M</au><au>SIVAM, GOWSALA P</au><au>SRINIVASAN, ANANTHACHARI</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANTIMERS AND ANTIMERIC CONJUGATION</title><date>1990-05-23</date><risdate>1990</risdate><abstract>There is disclosed an antibody and antibody-drug conjugate for targeting drug delivery as well as a class of chemicals, termed an "antimer." The antimer is designed to "fit" the drug by combining multiple non-covalent interactions between functional groups on the drug and opposing functional groups on the antimer. The net result on the antibody-antimer-drug conjugate is a drug stably bound to the antimer so as not to dissociate during in vivo administration, but not so tightly bound to allow drug dissociation from the conjugate without significant loss of activity and retaining the drug's ability to bind to a higher affinity site on the or within the target cell.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_EP0329184A3 |
| source | esp@cenet |
| subjects | CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | ANTIMERS AND ANTIMERIC CONJUGATION |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T16%3A36%3A53IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=PRIEST,%20JOHN%20H&rft.date=1990-05-23&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EEP0329184A3%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |