NEW PHENYLALKYLAMINE DERIVATIVES
Compounds with the general formula I wherein n is 0 or 1, Z is CO or CH(OH), R and R are equal or different and, when equal, hydrogen, methyl, ethyl or propyl and, when different, R is hydrogen and R is methyl, ethyl, propyl or isopropyl, X and Y represent hydrogen, halogen, CF3, CN or an alkyl grou...
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creator | OEGREN, SVEN OVE ULFF, CARL BENGT JOHAN LINDBERG, ULF HENRIK ANDERS HOEGBERG, THOMAS HALLNEMO, GERD MARGARETA AKESSON, CHRISTINA ELIZABETH GAWELL, LARS IVAR STROEM, HANS ERIC PETER |
description | Compounds with the general formula I wherein n is 0 or 1, Z is CO or CH(OH), R and R are equal or different and, when equal, hydrogen, methyl, ethyl or propyl and, when different, R is hydrogen and R is methyl, ethyl, propyl or isopropyl, X and Y represent hydrogen, halogen, CF3, CN or an alkyl group, straight or branched having 1-3 carbon atoms, in the ortho, meta or para position provided that when X is in the ortho position and other than hydrogen then Y is other than hydrogen, and when Y is in the ortho position and other than hydrogen then X is other than hydrogen, R represents a straight or branched saturated or unsaturated 1-6 carbon alkyl group, a 3-6 carbon cycloalkyl group, a phenyl group, which may be unsubstituted or may carry a ring substituent X , X preferably being a halogen, or R represents hydrogen, in racemic or optically active form and when Z is CH(OH) also mixtures of diastereomers or a pure diastereomer, with the proviso that the racemate of the compound wherein R and R is hydrogen, X is p-Cl, Y is hydrogen, Z is CO, n is 0 and R is methyl is excluded, or pharmaceutically acceptable salts thereof, processes for the production of said compounds and the use of the said compounds for the treatment of mental disturbances. |
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GAWELL, LARS IVAR ; STROEM, HANS ERIC PETER</creatorcontrib><description>Compounds with the general formula I wherein n is 0 or 1, Z is CO or CH(OH), R and R are equal or different and, when equal, hydrogen, methyl, ethyl or propyl and, when different, R is hydrogen and R is methyl, ethyl, propyl or isopropyl, X and Y represent hydrogen, halogen, CF3, CN or an alkyl group, straight or branched having 1-3 carbon atoms, in the ortho, meta or para position provided that when X is in the ortho position and other than hydrogen then Y is other than hydrogen, and when Y is in the ortho position and other than hydrogen then X is other than hydrogen, R represents a straight or branched saturated or unsaturated 1-6 carbon alkyl group, a 3-6 carbon cycloalkyl group, a phenyl group, which may be unsubstituted or may carry a ring substituent X , X preferably being a halogen, or R represents hydrogen, in racemic or optically active form and when Z is CH(OH) also mixtures of diastereomers or a pure diastereomer, with the proviso that the racemate of the compound wherein R and R is hydrogen, X is p-Cl, Y is hydrogen, Z is CO, n is 0 and R is methyl is excluded, or pharmaceutically acceptable salts thereof, processes for the production of said compounds and the use of the said compounds for the treatment of mental disturbances.</description><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1992</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19920325&DB=EPODOC&CC=EP&NR=0322391B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19920325&DB=EPODOC&CC=EP&NR=0322391B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>OEGREN, SVEN OVE</creatorcontrib><creatorcontrib>ULFF, CARL BENGT JOHAN</creatorcontrib><creatorcontrib>LINDBERG, ULF HENRIK ANDERS</creatorcontrib><creatorcontrib>HOEGBERG, THOMAS</creatorcontrib><creatorcontrib>HALLNEMO, GERD MARGARETA</creatorcontrib><creatorcontrib>AKESSON, CHRISTINA ELIZABETH</creatorcontrib><creatorcontrib>GAWELL, LARS IVAR</creatorcontrib><creatorcontrib>STROEM, HANS ERIC PETER</creatorcontrib><title>NEW PHENYLALKYLAMINE DERIVATIVES</title><description>Compounds with the general formula I wherein n is 0 or 1, Z is CO or CH(OH), R and R are equal or different and, when equal, hydrogen, methyl, ethyl or propyl and, when different, R is hydrogen and R is methyl, ethyl, propyl or isopropyl, X and Y represent hydrogen, halogen, CF3, CN or an alkyl group, straight or branched having 1-3 carbon atoms, in the ortho, meta or para position provided that when X is in the ortho position and other than hydrogen then Y is other than hydrogen, and when Y is in the ortho position and other than hydrogen then X is other than hydrogen, R represents a straight or branched saturated or unsaturated 1-6 carbon alkyl group, a 3-6 carbon cycloalkyl group, a phenyl group, which may be unsubstituted or may carry a ring substituent X , X preferably being a halogen, or R represents hydrogen, in racemic or optically active form and when Z is CH(OH) also mixtures of diastereomers or a pure diastereomer, with the proviso that the racemate of the compound wherein R and R is hydrogen, X is p-Cl, Y is hydrogen, Z is CO, n is 0 and R is methyl is excluded, or pharmaceutically acceptable salts thereof, processes for the production of said compounds and the use of the said compounds for the treatment of mental disturbances.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1992</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZFDwcw1XCPBw9Yv0cfTxBhK-nn6uCi6uQZ5hjiGeYa7BPAysaYk5xam8UJqbQcHNNcTZQze1ID8-tbggMTk1L7Uk3jXAwNjIyNjS0MnQmAglANC6IcA</recordid><startdate>19920325</startdate><enddate>19920325</enddate><creator>OEGREN, SVEN OVE</creator><creator>ULFF, CARL BENGT JOHAN</creator><creator>LINDBERG, ULF HENRIK ANDERS</creator><creator>HOEGBERG, THOMAS</creator><creator>HALLNEMO, GERD MARGARETA</creator><creator>AKESSON, CHRISTINA ELIZABETH</creator><creator>GAWELL, LARS IVAR</creator><creator>STROEM, HANS ERIC PETER</creator><scope>EVB</scope></search><sort><creationdate>19920325</creationdate><title>NEW PHENYLALKYLAMINE DERIVATIVES</title><author>OEGREN, SVEN OVE ; ULFF, CARL BENGT JOHAN ; LINDBERG, ULF HENRIK ANDERS ; HOEGBERG, THOMAS ; HALLNEMO, GERD MARGARETA ; AKESSON, CHRISTINA ELIZABETH ; GAWELL, LARS IVAR ; STROEM, HANS ERIC PETER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP0322391B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1992</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>OEGREN, SVEN OVE</creatorcontrib><creatorcontrib>ULFF, CARL BENGT JOHAN</creatorcontrib><creatorcontrib>LINDBERG, ULF HENRIK ANDERS</creatorcontrib><creatorcontrib>HOEGBERG, THOMAS</creatorcontrib><creatorcontrib>HALLNEMO, GERD MARGARETA</creatorcontrib><creatorcontrib>AKESSON, CHRISTINA ELIZABETH</creatorcontrib><creatorcontrib>GAWELL, LARS IVAR</creatorcontrib><creatorcontrib>STROEM, HANS ERIC PETER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>OEGREN, SVEN OVE</au><au>ULFF, CARL BENGT JOHAN</au><au>LINDBERG, ULF HENRIK ANDERS</au><au>HOEGBERG, THOMAS</au><au>HALLNEMO, GERD MARGARETA</au><au>AKESSON, CHRISTINA ELIZABETH</au><au>GAWELL, LARS IVAR</au><au>STROEM, HANS ERIC PETER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NEW PHENYLALKYLAMINE DERIVATIVES</title><date>1992-03-25</date><risdate>1992</risdate><abstract>Compounds with the general formula I wherein n is 0 or 1, Z is CO or CH(OH), R and R are equal or different and, when equal, hydrogen, methyl, ethyl or propyl and, when different, R is hydrogen and R is methyl, ethyl, propyl or isopropyl, X and Y represent hydrogen, halogen, CF3, CN or an alkyl group, straight or branched having 1-3 carbon atoms, in the ortho, meta or para position provided that when X is in the ortho position and other than hydrogen then Y is other than hydrogen, and when Y is in the ortho position and other than hydrogen then X is other than hydrogen, R represents a straight or branched saturated or unsaturated 1-6 carbon alkyl group, a 3-6 carbon cycloalkyl group, a phenyl group, which may be unsubstituted or may carry a ring substituent X , X preferably being a halogen, or R represents hydrogen, in racemic or optically active form and when Z is CH(OH) also mixtures of diastereomers or a pure diastereomer, with the proviso that the racemate of the compound wherein R and R is hydrogen, X is p-Cl, Y is hydrogen, Z is CO, n is 0 and R is methyl is excluded, or pharmaceutically acceptable salts thereof, processes for the production of said compounds and the use of the said compounds for the treatment of mental disturbances.</abstract><oa>free_for_read</oa></addata></record> |
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subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
title | NEW PHENYLALKYLAMINE DERIVATIVES |
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