New phenylalkylamine derivatives

Compounds with the general formula I wherein n is 0 or 1, Z is CO or CH(OH), R and R are equal or different and, when equal, hydrogen, methyl, ethyl or propyl and, when different, R is hydrogen and R is methyl, ethyl, propyl or isopropyl, X and Y represent hydrogen, halogen, CF3, CN or an alkyl grou...

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Hauptverfasser: STROM, HANS ERIC PETER, OGREN, SVEN OVE, HOGBERG, THOMAS, ULFF, CARL BENGT JOHAN, LINDBERG, ULF HENRIK ANDERS, HALLNEMO, GERD MARGARETA, AKESSON, CHRISTINA ELIZABETH, GAWELL, LARS IVAR
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creator STROM, HANS ERIC PETER
OGREN, SVEN OVE
HOGBERG, THOMAS
ULFF, CARL BENGT JOHAN
LINDBERG, ULF HENRIK ANDERS
HALLNEMO, GERD MARGARETA
AKESSON, CHRISTINA ELIZABETH
GAWELL, LARS IVAR
description Compounds with the general formula I wherein n is 0 or 1, Z is CO or CH(OH), R and R are equal or different and, when equal, hydrogen, methyl, ethyl or propyl and, when different, R is hydrogen and R is methyl, ethyl, propyl or isopropyl, X and Y represent hydrogen, halogen, CF3, CN or an alkyl group, straight or branched having 1-3 carbon atoms, in the ortho, meta or para position provided that when X is in the ortho position and other than hydrogen then Y is other than hydrogen, and when Y is in the ortho position and other than hydrogen then X is other than hydrogen, R represents a straight or branched saturated or unsaturated 1-6 carbon alkyl group, a 3-6 carbon cycloalkyl group, a phenyl group, which may be unsubstituted or may carry a ring substituent X , X preferably being a halogen, or R represents hydrogen, in racemic or optically active form and when Z is CH(OH) also mixtures of diastereomers or a pure diastereomer, with the proviso that the racemate of the compound wherein R and R is hydrogen, X is p-Cl, Y is hydrogen, Z is CO, n is 0 and R is methyl is excluded, or pharmaceutically acceptable salts thereof, processes for the production of said compounds and the use of the said compounds for the treatment of mental disturbances.
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language eng ; fre ; ger
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title New phenylalkylamine derivatives
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