1,4-Substituted piperidines as acetylcholinesterase inhibitors and their use for the treatment of Alzheimer's disease

Cyclic amine cpds. of formula (I) and their salts are new. - J is (a) a gp., opt. substd., of: phenyl, pyridyl, pyrazyl, cyclohexyl, quino(xa)lyl or furyl; (b) a monovalent or divalent gp., where the phenyl may have substit(s), of: indan(ol)yl, (iii) inden(on)yl, indan(edio)hyl, tetralonyl, benzosuberonyl, or C6H5-CO-CH(CH3)-; (c) a monovalent gp. derived from a cyclic amide cpd. (d) lower alkyl; or (e) R21-CH=CH- (R21 = H or (lower alkoxycarbonyl). B = (CHR22)r, CO(CHR22)r, NR4-(HCR22)r, CO-NR5-(CHR22)r, CH=CH-(CHR22)r, OCOO-(CHR22)r, OOC-NH-(CHR22)r, NH-CO-(CHR32)4, CH2CONH-(CHR22)r, (CH2)2CONH-(CHR22)r, CH(OH)-(CHR22)r, CH(OH)-(CHR22)r, = (CH-CH=CH)b, =CH-(CH2)c, =(CH-CH)d, COCH=CH-CH2, COCH2-CH(CH(OH)CH2, CH(CH3)CONHCH2, CH=CHCONH(CH2)2, NH, O, S, dialkylaminoalkylcarbonyl or lower alkoxycarbonyl; R4 = H, acyl, lower alkyl(sulphonyl), (substd.)phenyl, or (substd.)benzyl; R5 = H, lower alkyl or phenyl, r = 0-10; R22 = H or Me such that one alkylene may have no CH3 or one or more CH3; b = 1-3; c = 0-9; d = 0-5; T = N or C (i) Q = N, C or (i) q = 1-3; K = H, (substd.) phenyl, arylalkyl in which the phenyl may be substd. cinnamyl, lower alkyl, pyridylmethyl, cyclo(alkyl)alkyl, adamantanemethyl, furylmethyl, lower alkoxycarbonyl or acyl; and dotted lines is a single-or double-bond. - 1-benzyl-4-((5,6-dimethoxy -1-indanon)- 2-ylidenyl)methyl) piperidine hydrochlorideis and example.