PROCESS FOR PREPARATION OF CHOLESTYRAMINE
Known processes for preparing cholestyramine involve chloromethylating and aminating unfunctionalized styrene/divinylbenzene beads in the presence of added halogenated hydrocarbon swelling solvent, typically ethylene dichloride. The use of such halogenated swelling solvent is disadvantageous because...
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| creator | SIVIERI, FRANCO |
| description | Known processes for preparing cholestyramine involve chloromethylating and aminating unfunctionalized styrene/divinylbenzene beads in the presence of added halogenated hydrocarbon swelling solvent, typically ethylene dichloride. The use of such halogenated swelling solvent is disadvantageous because of toxicological implications. The present invention provides a process for preparing cholestyramine by chloromethylating and aminating unfunctionalized styrene/divinylbenzene copolymer beads, the chloromethylation and amination being conducted in the absence of added halogenated hydrocarbon swelling sovent. Furthermore, the cholestyramine produced by the process of the invention has improved palatability when compared with cholestyramine produced by known processes. |
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The use of such halogenated swelling solvent is disadvantageous because of toxicological implications. The present invention provides a process for preparing cholestyramine by chloromethylating and aminating unfunctionalized styrene/divinylbenzene copolymer beads, the chloromethylation and amination being conducted in the absence of added halogenated hydrocarbon swelling sovent. Furthermore, the cholestyramine produced by the process of the invention has improved palatability when compared with cholestyramine produced by known processes.</description><edition>4</edition><language>eng</language><subject>CHEMISTRY ; COMPOSITIONS BASED THEREON ; HUMAN NECESSITIES ; HYGIENE ; MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC MACROMOLECULAR COMPOUNDS ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS ; THEIR PREPARATION OR CHEMICAL WORKING-UP</subject><creationdate>1990</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19900502&DB=EPODOC&CC=EP&NR=0277795A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25544,76293</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19900502&DB=EPODOC&CC=EP&NR=0277795A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SIVIERI, FRANCO</creatorcontrib><title>PROCESS FOR PREPARATION OF CHOLESTYRAMINE</title><description>Known processes for preparing cholestyramine involve chloromethylating and aminating unfunctionalized styrene/divinylbenzene beads in the presence of added halogenated hydrocarbon swelling solvent, typically ethylene dichloride. The use of such halogenated swelling solvent is disadvantageous because of toxicological implications. The present invention provides a process for preparing cholestyramine by chloromethylating and aminating unfunctionalized styrene/divinylbenzene copolymer beads, the chloromethylation and amination being conducted in the absence of added halogenated hydrocarbon swelling sovent. 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The use of such halogenated swelling solvent is disadvantageous because of toxicological implications. The present invention provides a process for preparing cholestyramine by chloromethylating and aminating unfunctionalized styrene/divinylbenzene copolymer beads, the chloromethylation and amination being conducted in the absence of added halogenated hydrocarbon swelling sovent. Furthermore, the cholestyramine produced by the process of the invention has improved palatability when compared with cholestyramine produced by known processes.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
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| language | eng |
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| subjects | CHEMISTRY COMPOSITIONS BASED THEREON HUMAN NECESSITIES HYGIENE MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVINGCARBON-TO-CARBON UNSATURATED BONDS MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC MACROMOLECULAR COMPOUNDS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS THEIR PREPARATION OR CHEMICAL WORKING-UP |
| title | PROCESS FOR PREPARATION OF CHOLESTYRAMINE |
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