SMALL MOLECULAR WEIGHT ANTIGEN OF -i(PLASMODIUM) -i(FALCIPARUM)
Antigène de faible poids moléculaire des étapes sanguines asexuées de Plasmodium falciparum: (i) se caractérisant par un poids moléculaire apparent se situant approximativement entre 15 kD et 19 kD; (ii) présentant une acylation par l'acide myristique mais ne présentant pas de glycosylation sig...
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| creator | KARA, URSULA, ANNA, KATE STENZEL, DEBORAH, JOAN SAUL, ALLAN, JAMES GEYSEN, HENDRIK, MARIO BUSHELL, GILLIAN, ROBIN |
| description | Antigène de faible poids moléculaire des étapes sanguines asexuées de Plasmodium falciparum: (i) se caractérisant par un poids moléculaire apparent se situant approximativement entre 15 kD et 19 kD; (ii) présentant une acylation par l'acide myristique mais ne présentant pas de glycosylation significative par marquage à la galactose ou à la glucosamine; (iii) s'associant à la membrane des vacuoles parasitophores et aux inclusions et aux vésicules résidant dans le cytoplasme de la cellule hôte des érythrocytes; et (iv) se reconnaissant par des anticorps monoclonaux contre les étapes sanguines asexuées de P. falciparum qui inhibent la croissance de parasites in vitro; ou fragment antigénique dudit antigène. Un anticorps monoclonal spécifique dudit antigène et une lignée cellulaire hybride qui produit ledit anticorps sont également décrits.
A small molecular weight antigen of the asexual blood stages of Plasmodium falciparum which is characterized by: (i) having an apparent molecular weight in the range of approximately 15 kD to 19 kD; (ii) not showing significant glycosylation by galactose or glucosamine labelling, but being acylated by myristic acid; (iii) being associated with the parasitophorous vacuole membrane and with inclusions and vesicles residing within the cytoplasm of the erythrocyte host cell; and (iv) being recognised by monoclonal antibodies against the asexual blood stages of P. falciparum which inhibit parasite growth in vitro; or an antigenic fragment thereof. A monoclonal antibody specific for this antigen, and a hybrid cell line which produces this antibody is also disclosed. |
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A small molecular weight antigen of the asexual blood stages of Plasmodium falciparum which is characterized by: (i) having an apparent molecular weight in the range of approximately 15 kD to 19 kD; (ii) not showing significant glycosylation by galactose or glucosamine labelling, but being acylated by myristic acid; (iii) being associated with the parasitophorous vacuole membrane and with inclusions and vesicles residing within the cytoplasm of the erythrocyte host cell; and (iv) being recognised by monoclonal antibodies against the asexual blood stages of P. falciparum which inhibit parasite growth in vitro; or an antigenic fragment thereof. A monoclonal antibody specific for this antigen, and a hybrid cell line which produces this antibody is also disclosed.</description><edition>4</edition><language>eng ; fre ; ger</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; COMPOSITIONS THEREOF ; CULTURE MEDIA ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; MICROBIOLOGY ; MICROORGANISMS OR ENZYMES ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; PROCESSES USING MICROORGANISMS ; PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>1988</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19880713&DB=EPODOC&CC=EP&NR=0273971A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76290</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19880713&DB=EPODOC&CC=EP&NR=0273971A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KARA, URSULA, ANNA, KATE</creatorcontrib><creatorcontrib>STENZEL, DEBORAH, JOAN</creatorcontrib><creatorcontrib>SAUL, ALLAN, JAMES</creatorcontrib><creatorcontrib>GEYSEN, HENDRIK, MARIO</creatorcontrib><creatorcontrib>BUSHELL, GILLIAN, ROBIN</creatorcontrib><title>SMALL MOLECULAR WEIGHT ANTIGEN OF -i(PLASMODIUM) -i(FALCIPARUM)</title><description>Antigène de faible poids moléculaire des étapes sanguines asexuées de Plasmodium falciparum: (i) se caractérisant par un poids moléculaire apparent se situant approximativement entre 15 kD et 19 kD; (ii) présentant une acylation par l'acide myristique mais ne présentant pas de glycosylation significative par marquage à la galactose ou à la glucosamine; (iii) s'associant à la membrane des vacuoles parasitophores et aux inclusions et aux vésicules résidant dans le cytoplasme de la cellule hôte des érythrocytes; et (iv) se reconnaissant par des anticorps monoclonaux contre les étapes sanguines asexuées de P. falciparum qui inhibent la croissance de parasites in vitro; ou fragment antigénique dudit antigène. Un anticorps monoclonal spécifique dudit antigène et une lignée cellulaire hybride qui produit ledit anticorps sont également décrits.
A small molecular weight antigen of the asexual blood stages of Plasmodium falciparum which is characterized by: (i) having an apparent molecular weight in the range of approximately 15 kD to 19 kD; (ii) not showing significant glycosylation by galactose or glucosamine labelling, but being acylated by myristic acid; (iii) being associated with the parasitophorous vacuole membrane and with inclusions and vesicles residing within the cytoplasm of the erythrocyte host cell; and (iv) being recognised by monoclonal antibodies against the asexual blood stages of P. falciparum which inhibit parasite growth in vitro; or an antigenic fragment thereof. A monoclonal antibody specific for this antigen, and a hybrid cell line which produces this antibody is also disclosed.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROCESSES USING MICROORGANISMS</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1988</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLAP9nX08VHw9fdxdQ71cQxSCHf1dPcIUXD0C_F0d_VT8HdT0M3UCPBxDPb1d_EM9dUEcd0cfZw9AxyDgFweBta0xJziVF4ozc2g4OYa4uyhm1qQH59aXJCYnJqXWhLvGmBgZG5saW7oaGhMhBIAEq0ptQ</recordid><startdate>19880713</startdate><enddate>19880713</enddate><creator>KARA, URSULA, ANNA, KATE</creator><creator>STENZEL, DEBORAH, JOAN</creator><creator>SAUL, ALLAN, JAMES</creator><creator>GEYSEN, HENDRIK, MARIO</creator><creator>BUSHELL, GILLIAN, ROBIN</creator><scope>EVB</scope></search><sort><creationdate>19880713</creationdate><title>SMALL MOLECULAR WEIGHT ANTIGEN OF -i(PLASMODIUM) -i(FALCIPARUM)</title><author>KARA, URSULA, ANNA, KATE ; STENZEL, DEBORAH, JOAN ; SAUL, ALLAN, JAMES ; GEYSEN, HENDRIK, MARIO ; BUSHELL, GILLIAN, ROBIN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP0273971A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>1988</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROCESSES USING MICROORGANISMS</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>KARA, URSULA, ANNA, KATE</creatorcontrib><creatorcontrib>STENZEL, DEBORAH, JOAN</creatorcontrib><creatorcontrib>SAUL, ALLAN, JAMES</creatorcontrib><creatorcontrib>GEYSEN, HENDRIK, MARIO</creatorcontrib><creatorcontrib>BUSHELL, GILLIAN, ROBIN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KARA, URSULA, ANNA, KATE</au><au>STENZEL, DEBORAH, JOAN</au><au>SAUL, ALLAN, JAMES</au><au>GEYSEN, HENDRIK, MARIO</au><au>BUSHELL, GILLIAN, ROBIN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>SMALL MOLECULAR WEIGHT ANTIGEN OF -i(PLASMODIUM) -i(FALCIPARUM)</title><date>1988-07-13</date><risdate>1988</risdate><abstract>Antigène de faible poids moléculaire des étapes sanguines asexuées de Plasmodium falciparum: (i) se caractérisant par un poids moléculaire apparent se situant approximativement entre 15 kD et 19 kD; (ii) présentant une acylation par l'acide myristique mais ne présentant pas de glycosylation significative par marquage à la galactose ou à la glucosamine; (iii) s'associant à la membrane des vacuoles parasitophores et aux inclusions et aux vésicules résidant dans le cytoplasme de la cellule hôte des érythrocytes; et (iv) se reconnaissant par des anticorps monoclonaux contre les étapes sanguines asexuées de P. falciparum qui inhibent la croissance de parasites in vitro; ou fragment antigénique dudit antigène. Un anticorps monoclonal spécifique dudit antigène et une lignée cellulaire hybride qui produit ledit anticorps sont également décrits.
A small molecular weight antigen of the asexual blood stages of Plasmodium falciparum which is characterized by: (i) having an apparent molecular weight in the range of approximately 15 kD to 19 kD; (ii) not showing significant glycosylation by galactose or glucosamine labelling, but being acylated by myristic acid; (iii) being associated with the parasitophorous vacuole membrane and with inclusions and vesicles residing within the cytoplasm of the erythrocyte host cell; and (iv) being recognised by monoclonal antibodies against the asexual blood stages of P. falciparum which inhibit parasite growth in vitro; or an antigenic fragment thereof. A monoclonal antibody specific for this antigen, and a hybrid cell line which produces this antibody is also disclosed.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROCESSES USING MICROORGANISMS PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPIRITS VINEGAR WINE |
| title | SMALL MOLECULAR WEIGHT ANTIGEN OF -i(PLASMODIUM) -i(FALCIPARUM) |
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