TETRAENYL PROSTAGLANDINS

TETRAENYL PROSTAGLANDINS

This invention encompasses prostaglandins of the for- mJlawherein R represents hydrogen or lower alkyl having 1 to 6 carbon atoms; R, represents hydrogen, vinyl, or lower alkyl having 1 to 4 carbon atoms and the wavy line represents R or S stereochemistry; R2, R3, and R4 are hydrogen or lower alkyl...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: GASIECKI, ALAN FRANK, COLLINS, PAUL WADDELL
Format: Patent
Sprache:eng
Schlagworte:
ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Beschreibung
Zusammenfassung:This invention encompasses prostaglandins of the for- mJlawherein R represents hydrogen or lower alkyl having 1 to 6 carbon atoms; R, represents hydrogen, vinyl, or lower alkyl having 1 to 4 carbon atoms and the wavy line represents R or S stereochemistry; R2, R3, and R4 are hydrogen or lower alkyl having 1 to 4 carbon atoms or R2 and R3 together with carbon Y form a cycloalkenyl having 4 to 6 carbon atoms or R3 and R4 together with carbons X and Y form a cycloalkenyl having 4 to 6 carbons. Compounds of this invention have potent gastric antisecretory and cytoprotective properties with unexpectedly low diarrheogenic side effects.