CARBAMATES AND UREAS OF N-(2-AMINOACYLAMIDO-2-DESOXY-HEXOSYL) AMIDE, METHOD FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE
Compounds of the formula in which R1 denotes hydrogen or a saturated or singly or multiply unsaturated alkyl radical having up to 50 carbon atoms, X represents -CH2-, -O-or -NH-, R2 denotes hydrogen or a saturated or singly or multiply unsaturated alkyl radical having up to 50 carbon atoms, R3, R4 a...
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creator | ZEILER, HANS-JOACHIM BRUNNER, DR STREISSLE, GERT PAESSENS, ARNOLD STADLER, PETER STUENKEL, KLAUS GEORG KROLL, HEIN-PETER LOCKHOFF, OSWALD KLIMETZEK SCHALLER, KLAUS HAYAUCHI, YUTAKA METZGER, KARL GEORG |
description | Compounds of the formula in which R1 denotes hydrogen or a saturated or singly or multiply unsaturated alkyl radical having up to 50 carbon atoms, X represents -CH2-, -O-or -NH-, R2 denotes hydrogen or a saturated or singly or multiply unsaturated alkyl radical having up to 50 carbon atoms, R3, R4 and R5, independently of one another, denotes hydrogen or acyl-CO-R6, R6 being an alkyl radical having up to 10 carbon atoms, R7 denotes hydrogen, C1-C7-alkyl-, hydroxymethyl, 1-hydroxyethyl, mercaptomethyl, 2-(methylthio)-ethyl, 3-aminopropyl, 3-ureidopropyl, 3-quanidyl-propyl, 4-aminobutyl, carboxymethyl, carbamylmethyl, 2-carboxyethyl, 2-carbamoylethyl, benzyl, 4-hydroxybenzyl, 3-indolylmethyl or 4-imidazolylmethyl, and R8 represents hydrogen or methyl, and R9 represents hydrogen, acetyl, benzoyl, trichloroacetyl, trifluoroacetyl, methoxycarbonyl, t-butyloxycarbonyl or benzyloxycarbonyl and R7 and R8 together can denote -CH2-CH2-CH2, and pharmaceutically acceptable salts thereof stimulate the immune system and can be used in conjuction with antibiotics and vaccines. New intermediates are also shown. |
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New intermediates are also shown.</description><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SUGARS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1992</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNjL0KwjAURrs4iPoOd1QwUCvofJvckkDTW5IU2qkUiZNooc4-uz_0AZzOx-HjLJOXRJejxUAesFLQOEIPXEAltplAaypG2ZWfoVhkQpHnthOaWvZduYOvpz1YCpoVFOwgaDIOakc1OgyGq192thqdRUlNMBJLaDytk8V1uE1xM3OVQEFBahHHRx-ncbjEe3z2VKdZekqP5_xw_OPyBgF3OnU</recordid><startdate>19920115</startdate><enddate>19920115</enddate><creator>ZEILER, HANS-JOACHIM</creator><creator>BRUNNER, DR</creator><creator>STREISSLE, GERT</creator><creator>PAESSENS, ARNOLD</creator><creator>STADLER, PETER</creator><creator>STUENKEL, KLAUS GEORG</creator><creator>KROLL, HEIN-PETER</creator><creator>LOCKHOFF, OSWALD</creator><creator>KLIMETZEK</creator><creator>SCHALLER, KLAUS</creator><creator>HAYAUCHI, YUTAKA</creator><creator>METZGER, KARL GEORG</creator><scope>EVB</scope></search><sort><creationdate>19920115</creationdate><title>CARBAMATES AND UREAS OF N-(2-AMINOACYLAMIDO-2-DESOXY-HEXOSYL) AMIDE, METHOD FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE</title><author>ZEILER, HANS-JOACHIM ; BRUNNER, DR ; STREISSLE, GERT ; PAESSENS, ARNOLD ; STADLER, PETER ; STUENKEL, KLAUS GEORG ; KROLL, HEIN-PETER ; LOCKHOFF, OSWALD ; KLIMETZEK ; SCHALLER, KLAUS ; HAYAUCHI, YUTAKA ; METZGER, KARL GEORG</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP0206037B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; ger</language><creationdate>1992</creationdate><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SUGARS</topic><toplevel>online_resources</toplevel><creatorcontrib>ZEILER, HANS-JOACHIM</creatorcontrib><creatorcontrib>BRUNNER, DR</creatorcontrib><creatorcontrib>STREISSLE, GERT</creatorcontrib><creatorcontrib>PAESSENS, ARNOLD</creatorcontrib><creatorcontrib>STADLER, PETER</creatorcontrib><creatorcontrib>STUENKEL, KLAUS GEORG</creatorcontrib><creatorcontrib>KROLL, HEIN-PETER</creatorcontrib><creatorcontrib>LOCKHOFF, OSWALD</creatorcontrib><creatorcontrib>KLIMETZEK</creatorcontrib><creatorcontrib>SCHALLER, KLAUS</creatorcontrib><creatorcontrib>HAYAUCHI, YUTAKA</creatorcontrib><creatorcontrib>METZGER, KARL GEORG</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ZEILER, HANS-JOACHIM</au><au>BRUNNER, DR</au><au>STREISSLE, GERT</au><au>PAESSENS, ARNOLD</au><au>STADLER, PETER</au><au>STUENKEL, KLAUS GEORG</au><au>KROLL, HEIN-PETER</au><au>LOCKHOFF, OSWALD</au><au>KLIMETZEK</au><au>SCHALLER, KLAUS</au><au>HAYAUCHI, YUTAKA</au><au>METZGER, KARL GEORG</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>CARBAMATES AND UREAS OF N-(2-AMINOACYLAMIDO-2-DESOXY-HEXOSYL) AMIDE, METHOD FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE</title><date>1992-01-15</date><risdate>1992</risdate><abstract>Compounds of the formula in which R1 denotes hydrogen or a saturated or singly or multiply unsaturated alkyl radical having up to 50 carbon atoms, X represents -CH2-, -O-or -NH-, R2 denotes hydrogen or a saturated or singly or multiply unsaturated alkyl radical having up to 50 carbon atoms, R3, R4 and R5, independently of one another, denotes hydrogen or acyl-CO-R6, R6 being an alkyl radical having up to 10 carbon atoms, R7 denotes hydrogen, C1-C7-alkyl-, hydroxymethyl, 1-hydroxyethyl, mercaptomethyl, 2-(methylthio)-ethyl, 3-aminopropyl, 3-ureidopropyl, 3-quanidyl-propyl, 4-aminobutyl, carboxymethyl, carbamylmethyl, 2-carboxyethyl, 2-carbamoylethyl, benzyl, 4-hydroxybenzyl, 3-indolylmethyl or 4-imidazolylmethyl, and R8 represents hydrogen or methyl, and R9 represents hydrogen, acetyl, benzoyl, trichloroacetyl, trifluoroacetyl, methoxycarbonyl, t-butyloxycarbonyl or benzyloxycarbonyl and R7 and R8 together can denote -CH2-CH2-CH2, and pharmaceutically acceptable salts thereof stimulate the immune system and can be used in conjuction with antibiotics and vaccines. New intermediates are also shown.</abstract><oa>free_for_read</oa></addata></record> |
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subjects | CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS |
title | CARBAMATES AND UREAS OF N-(2-AMINOACYLAMIDO-2-DESOXY-HEXOSYL) AMIDE, METHOD FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL USE |
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