DIHYDROPYRIDINE CALCIUM ANTAGONISTS

DIHYDROPYRIDINE CALCIUM ANTAGONISTS

Dihydropyridine calcium antagonists, useful in the treatment of conditions such an angina and hypertension, of the formula:- where R is an optionally substituted aryl or heteroaryl group; R and R are each independently selected from i) C1-C4 alkyl and ii) C1-C4 alkyl substituted by C3-C7 cycloalkyl,...

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Hauptverfasser: CAMPBELL, SIMON FRASER, ALKER, DAVID
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator CAMPBELL, SIMON FRASER
ALKER, DAVID
description Dihydropyridine calcium antagonists, useful in the treatment of conditions such an angina and hypertension, of the formula:- where R is an optionally substituted aryl or heteroaryl group; R and R are each independently selected from i) C1-C4 alkyl and ii) C1-C4 alkyl substituted by C3-C7 cycloalkyl, aryl, CF3, C2-C4 alkanoyl, halo, hydroxy, C1-C4 alkoxy, C2-C4 alkanoyloxy, aryl-(C1-C4 alkoxy), or -NR R ; m is 0, 1 or 2; R is H, C1-C4 alkyl or -COCF3; R is H or C1-C4 alkyl; R is H, C1-C4 alkyl or aryl-(C1-C4 alkyl); and Y is (CH2)n where n is 2,3 or 4, -CH2CH(CH3)- or -CH2C(CH3)2-; and their pharmaceutically acceptable salts. e
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title DIHYDROPYRIDINE CALCIUM ANTAGONISTS
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