7-(PYRIDINYL)-/-ALKYL-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLIC ACID HAVING ANTIBACTERIAL ACTIVITY AND PREPARATION THEREOF

7-(PYRIDINYL)-/-ALKYL-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLIC ACID HAVING ANTIBACTERIAL ACTIVITY AND PREPARATION THEREOF

1-Ethyl-6-fluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quin olinecarboxylic acid or salt thereof, a novel compound useful highly potent antibacterial agent with a broad spectrum of anti-microbiai activity, is prepared by nitrating the corresponding 6-desfluoro compound to produce the corr...

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Hauptverfasser: LESHER, GEORGE YOHE, BALDEV, SINGH, DAUM, SOL JACOB
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Sprache:eng
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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creator LESHER, GEORGE YOHE
BALDEV, SINGH
DAUM, SOL JACOB
description 1-Ethyl-6-fluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quin olinecarboxylic acid or salt thereof, a novel compound useful highly potent antibacterial agent with a broad spectrum of anti-microbiai activity, is prepared by nitrating the corresponding 6-desfluoro compound to produce the corresponding 6-nitro compound, reducing the latter compound to produce the corresponding 6-amino compound and converting the 6-amino via its diazonium salt to said 6-fluoro compound. Said novel acid is also prepared via intermediates prepared by heating 4-(2-fluorophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid to produce a mixture of 4-(2-fluorophenyl)-2,6-di-methylpyridine and 2,4-dimethyl-5H-[1]benzopyrano[3,4-c]pyridin-5-one, separating the components of said mixture and nitrating 4-(2-fluorophenyl)-2,6-dimethylpyridine to produce 4-(2-fluoro-5-nitrophenyl)-2,6-dimethylpyridine.
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Said novel acid is also prepared via intermediates prepared by heating 4-(2-fluorophenyl)-2,6-dimethyl-3,5-pyridinedicarboxylic acid to produce a mixture of 4-(2-fluorophenyl)-2,6-di-methylpyridine and 2,4-dimethyl-5H-[1]benzopyrano[3,4-c]pyridin-5-one, separating the components of said mixture and nitrating 4-(2-fluorophenyl)-2,6-dimethylpyridine to produce 4-(2-fluoro-5-nitrophenyl)-2,6-dimethylpyridine.</description><edition>4</edition><language>eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>1986</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=19860813&amp;DB=EPODOC&amp;CC=EP&amp;NR=0179239A3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,777,882,25545,76296</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=19860813&amp;DB=EPODOC&amp;CC=EP&amp;NR=0179239A3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LESHER, GEORGE YOHE</creatorcontrib><creatorcontrib>BALDEV, SINGH</creatorcontrib><creatorcontrib>DAUM, SOL JACOB</creatorcontrib><title>7-(PYRIDINYL)-/-ALKYL-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLIC ACID HAVING ANTIBACTERIAL ACTIVITY AND PREPARATION THEREOF</title><description>1-Ethyl-6-fluoro-1,4-dihydro-7-(2,6-dimethyl-4-pyridinyl)-4-oxo-3-quin olinecarboxylic acid or salt thereof, a novel compound useful highly potent antibacterial agent with a broad spectrum of anti-microbiai activity, is prepared by nitrating the corresponding 6-desfluoro compound to produce the corresponding 6-nitro compound, reducing the latter compound to produce the corresponding 6-amino compound and converting the 6-amino via its diazonium salt to said 6-fluoro compound. 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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
title 7-(PYRIDINYL)-/-ALKYL-1,4-DIHYDRO-4-OXO-3-QUINOLINECARBOXYLIC ACID HAVING ANTIBACTERIAL ACTIVITY AND PREPARATION THEREOF
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