ANTI-INFLAMMATORY PHTHALAZINONES

A compound useful as anti-inflammatory agents in warm-blooded animals of the formula wherein X is a member of the class of ethylene and ethenyl and is substituted for hydrogen in the sixth or seventh position of the 1(2H)-phthalazinone ring Y is a member of the class of hydrogen and hydroxyl R1 is a...

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Hauptverfasser: THOMAS, TELFER LAWSON, RADOV, LESLEY ANN
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creator THOMAS, TELFER LAWSON
RADOV, LESLEY ANN
description A compound useful as anti-inflammatory agents in warm-blooded animals of the formula wherein X is a member of the class of ethylene and ethenyl and is substituted for hydrogen in the sixth or seventh position of the 1(2H)-phthalazinone ring Y is a member of the class of hydrogen and hydroxyl R1 is a member of the class of hydrogen, alkyl, alkoxy, hydroxyl, halogen, nitro, -NR3R4, -COR5 and -O-A wherein A is a mineral acid residue which with -O- forms an ester or the alkali metal salt of said ester, R2 is a member of the class of hydrogen, alkyl, phenyl, substituted phenyl, heteroaryl, hydroxyalkylene, polyhydroxyalkylene, aminoalkylene, alkylaminoalkylene, and carboxyalkylene, R3, R4 are independently from the class of hydrogen, alkyl, aminoalkylene or alkylaminoalkylene, R5 is a member of the class of OR3 and for example hydroxyl, methoxyl, 2-dimethylaminoethoxyl or 2-dimethylaminoethylamino, and wherein by alkyl and alkylene is meant respectively a mono- or divalent saturated aliphatic radical containing up to about eight carbon atoms, wherein the nitrogen of the alkylamino or alkylaminoalkylene may form a heterocycle with the alkyl or alkylene groups, wherein substituted phenyl may be substituted by, for example, alkyl, hydroxyl, alkoxy, halogen, nitro or amino, wherein heteroaryl may be, for example, 2-pyridyl.
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RADOV, LESLEY ANN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP0164593B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1989</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>THOMAS, TELFER LAWSON</creatorcontrib><creatorcontrib>RADOV, LESLEY ANN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>THOMAS, TELFER LAWSON</au><au>RADOV, LESLEY ANN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ANTI-INFLAMMATORY PHTHALAZINONES</title><date>1989-11-15</date><risdate>1989</risdate><abstract>A compound useful as anti-inflammatory agents in warm-blooded animals of the formula wherein X is a member of the class of ethylene and ethenyl and is substituted for hydrogen in the sixth or seventh position of the 1(2H)-phthalazinone ring Y is a member of the class of hydrogen and hydroxyl R1 is a member of the class of hydrogen, alkyl, alkoxy, hydroxyl, halogen, nitro, -NR3R4, -COR5 and -O-A wherein A is a mineral acid residue which with -O- forms an ester or the alkali metal salt of said ester, R2 is a member of the class of hydrogen, alkyl, phenyl, substituted phenyl, heteroaryl, hydroxyalkylene, polyhydroxyalkylene, aminoalkylene, alkylaminoalkylene, and carboxyalkylene, R3, R4 are independently from the class of hydrogen, alkyl, aminoalkylene or alkylaminoalkylene, R5 is a member of the class of OR3 and for example hydroxyl, methoxyl, 2-dimethylaminoethoxyl or 2-dimethylaminoethylamino, and wherein by alkyl and alkylene is meant respectively a mono- or divalent saturated aliphatic radical containing up to about eight carbon atoms, wherein the nitrogen of the alkylamino or alkylaminoalkylene may form a heterocycle with the alkyl or alkylene groups, wherein substituted phenyl may be substituted by, for example, alkyl, hydroxyl, alkoxy, halogen, nitro or amino, wherein heteroaryl may be, for example, 2-pyridyl.</abstract><oa>free_for_read</oa></addata></record>
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title ANTI-INFLAMMATORY PHTHALAZINONES
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