RACEMIC AND OPTICALLY ACTIVE 7-OXO-PROSTACYCLIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS
Compounds of the formula I are disclosed wherein R1 stands for hydrogen, C1-4 straight or branched alkyl or pharmacologically acceptable cation, R2 stands for hydrogen, C1-4 alkanoyl, benzoyl, or benzoyl substituted by C1-4 alkyl or halogen, and R2 can further represent tetrahydropyranyl, trialkylsi...
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| creator | GYORY, PETER TOMOSKOZI, ISTVAN GALAMBOS, GEZA KANAY, KAROLY VIRAG, SANDOR IVANICS, JOZSEF KORMOCZY, PETER STADLER, ISTVAN DORMAN, GYORGY KOVACS, GABOR KOVACS, MARIANNA |
| description | Compounds of the formula I are disclosed wherein R1 stands for hydrogen, C1-4 straight or branched alkyl or pharmacologically acceptable cation, R2 stands for hydrogen, C1-4 alkanoyl, benzoyl, or benzoyl substituted by C1-4 alkyl or halogen, and R2 can further represent tetrahydropyranyl, trialkylsilyl or alkoxyalkyl, A stands for ethylene, cis or trans-vinylene or -C=C-, n may represent 2, 3 or 4. The compounds are highly effective in the inhibition of thrombocyte aggregation while at the same time exert only a very small hypotensive effect. |
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The compounds are highly effective in the inhibition of thrombocyte aggregation while at the same time exert only a very small hypotensive effect.</description><edition>4</edition><language>eng ; ger</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1989</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19890125&DB=EPODOC&CC=EP&NR=0163905B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19890125&DB=EPODOC&CC=EP&NR=0163905B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>GYORY, PETER</creatorcontrib><creatorcontrib>TOMOSKOZI, ISTVAN</creatorcontrib><creatorcontrib>GALAMBOS, GEZA</creatorcontrib><creatorcontrib>KANAY, KAROLY</creatorcontrib><creatorcontrib>VIRAG, SANDOR</creatorcontrib><creatorcontrib>IVANICS, JOZSEF</creatorcontrib><creatorcontrib>KORMOCZY, PETER</creatorcontrib><creatorcontrib>STADLER, ISTVAN</creatorcontrib><creatorcontrib>DORMAN, GYORGY</creatorcontrib><creatorcontrib>KOVACS, GABOR</creatorcontrib><creatorcontrib>KOVACS, MARIANNA</creatorcontrib><title>RACEMIC AND OPTICALLY ACTIVE 7-OXO-PROSTACYCLIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS</title><description>Compounds of the formula I are disclosed wherein R1 stands for hydrogen, C1-4 straight or branched alkyl or pharmacologically acceptable cation, R2 stands for hydrogen, C1-4 alkanoyl, benzoyl, or benzoyl substituted by C1-4 alkyl or halogen, and R2 can further represent tetrahydropyranyl, trialkylsilyl or alkoxyalkyl, A stands for ethylene, cis or trans-vinylene or -C=C-, n may represent 2, 3 or 4. The compounds are highly effective in the inhibition of thrombocyte aggregation while at the same time exert only a very small hypotensive effect.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1989</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNzcEKwjAMBuBdPIj6DnkABxNR8RizzAW2trTd0JMMqSfRgb6K72unPoCnkHzJn3HyskhcCwGqHLTxQlhVR0Dy0jJsUn3QqbHaeaQjVaIgZystDurmEIXYOSi0BV-y2Dhhgza6Vp9IU6Kt44vmkwyka6OdDOxiozyKErUfjh1_tVG5myajS3d9hNmvThIo2FOZhv5-Co--O4dbeJ7YZIv1cputdovlHytvWZRCHQ</recordid><startdate>19890125</startdate><enddate>19890125</enddate><creator>GYORY, PETER</creator><creator>TOMOSKOZI, ISTVAN</creator><creator>GALAMBOS, GEZA</creator><creator>KANAY, KAROLY</creator><creator>VIRAG, SANDOR</creator><creator>IVANICS, JOZSEF</creator><creator>KORMOCZY, PETER</creator><creator>STADLER, ISTVAN</creator><creator>DORMAN, GYORGY</creator><creator>KOVACS, GABOR</creator><creator>KOVACS, MARIANNA</creator><scope>EVB</scope></search><sort><creationdate>19890125</creationdate><title>RACEMIC AND OPTICALLY ACTIVE 7-OXO-PROSTACYCLIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS</title><author>GYORY, PETER ; TOMOSKOZI, ISTVAN ; GALAMBOS, GEZA ; KANAY, KAROLY ; VIRAG, SANDOR ; IVANICS, JOZSEF ; KORMOCZY, PETER ; STADLER, ISTVAN ; DORMAN, GYORGY ; KOVACS, GABOR ; KOVACS, MARIANNA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP0163905B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; ger</language><creationdate>1989</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>GYORY, PETER</creatorcontrib><creatorcontrib>TOMOSKOZI, ISTVAN</creatorcontrib><creatorcontrib>GALAMBOS, GEZA</creatorcontrib><creatorcontrib>KANAY, KAROLY</creatorcontrib><creatorcontrib>VIRAG, SANDOR</creatorcontrib><creatorcontrib>IVANICS, JOZSEF</creatorcontrib><creatorcontrib>KORMOCZY, PETER</creatorcontrib><creatorcontrib>STADLER, ISTVAN</creatorcontrib><creatorcontrib>DORMAN, GYORGY</creatorcontrib><creatorcontrib>KOVACS, GABOR</creatorcontrib><creatorcontrib>KOVACS, MARIANNA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>GYORY, PETER</au><au>TOMOSKOZI, ISTVAN</au><au>GALAMBOS, GEZA</au><au>KANAY, KAROLY</au><au>VIRAG, SANDOR</au><au>IVANICS, JOZSEF</au><au>KORMOCZY, PETER</au><au>STADLER, ISTVAN</au><au>DORMAN, GYORGY</au><au>KOVACS, GABOR</au><au>KOVACS, MARIANNA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>RACEMIC AND OPTICALLY ACTIVE 7-OXO-PROSTACYCLIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS</title><date>1989-01-25</date><risdate>1989</risdate><abstract>Compounds of the formula I are disclosed wherein R1 stands for hydrogen, C1-4 straight or branched alkyl or pharmacologically acceptable cation, R2 stands for hydrogen, C1-4 alkanoyl, benzoyl, or benzoyl substituted by C1-4 alkyl or halogen, and R2 can further represent tetrahydropyranyl, trialkylsilyl or alkoxyalkyl, A stands for ethylene, cis or trans-vinylene or -C=C-, n may represent 2, 3 or 4. The compounds are highly effective in the inhibition of thrombocyte aggregation while at the same time exert only a very small hypotensive effect.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | RACEMIC AND OPTICALLY ACTIVE 7-OXO-PROSTACYCLIN DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THESE COMPOUNDS |
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