2-SUBSTITUTED ERGOLINE DERIVATIVES, PROCESSES FOR THEIR PREPARATION, AND THEIR USE AS MEDICAMENTS

Novel ergoline derivatives, substituted in the 2-position, of the formula (I) wherein C8---C9 and C9---C10 each independently is a CC-single or a C=C-double bond, but not together a cumulated double bond, and the substituent in the 8-position is in the alpha - or beta -configuration where C8---C9 is a CC-single bond, R2 is a CN, SR, SOR, wherein n is 2 or 3, and -CH(OR)R wherein R has the meaning of H or C1-4-alkyl, the grouping COR' and CSR' wherein R'=OH, OC1-4-alkyl, benzyl, NH2 or NHR'', the grouping CH=CH-CO2R'' and CH2-CH2-CO2R' wherein R''=C1-4-alkyl, the grouping C 3BOND C-R''' and HC=CH-R''' wherein R'''=hydrogen, C1-4-alkyl, phenyl, CH2OH, CR''2OH, CO2R'', CH2NR''2 or SiMe2R''; C1-3-alkyl, or C1-3-alkyl substituted by OH or phenyl; or wherein R'' is C1-4 alkyl, R6 is C1-4-alkyl and R8 is methyl, NH-CO-NEt2 or NH-CS-NEt2, and the physiologically acceptable acid addition salt thereof, possess biological efficacy in the region of the central nervous system,, e.g., as neuroleptics and antidepressants.