PROCESS FOR AN ANTHRACYCLINE DERIVATIVE, AND AN ANTHRACYCLINONE DERIVATIVE USEFUL FOR THE PROCESS
A process for producing an anthracycline derivative represented by the general formula:where R1 is an acyl group, each of X1 and X2 is a hydrogen atom, a methoxy group, a hydroxyl group, a halogen atom or a lower alkyl group, each of Y1 and Y2 is a hydrogen atom, an alkoxy group or a hydroxyl group,...
Gespeichert in:
| Hauptverfasser: | , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | ABE, RUMIKO MATSUMOTO, TERUYO SUZUKI, MICHIYO TERASHIMA, SHIRO KIMURA, YOSHIKAZU |
| description | A process for producing an anthracycline derivative represented by the general formula:where R1 is an acyl group, each of X1 and X2 is a hydrogen atom, a methoxy group, a hydroxyl group, a halogen atom or a lower alkyl group, each of Y1 and Y2 is a hydrogen atom, an alkoxy group or a hydroxyl group, and Z is a hydrogen atom or a protected hydroxyl group, which comprises reacting an anthracyclinone derivative represented by the general formula:where R is a hydrogen atom or a trialkylsilyl group, and X1, X2, Y1, Y2 and Z are as defined above, with a 1-acylsugar derivative represented by the general formula:where R2 is an acyl group and R1 is as defined above, in the presence of a silyl sulfonic acid derivative represented by the general formula:where each of R3, R4 and R5 is an alkyl group and A is an alkyl group, an aryl group, a polyfluoroalkyl group or a hydrogen atom. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP0143323B1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP0143323B1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP0143323B13</originalsourceid><addsrcrecordid>eNrjZEgMCPJ3dg0OVnDzD1Jw9AOiEI8gR-dIZx9PP1cFF9cgzzDHEM8wVx2gjAu6An8UJQqhwa5uoT5gk0I8XBWgJvMwsKYl5hSn8kJpbgYFN9cQZw_d1IL8-NTigsTk1LzUknjXAANDE2NjI2MnQ2MilAAASuUzPQ</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>PROCESS FOR AN ANTHRACYCLINE DERIVATIVE, AND AN ANTHRACYCLINONE DERIVATIVE USEFUL FOR THE PROCESS</title><source>esp@cenet</source><creator>ABE, RUMIKO ; MATSUMOTO, TERUYO ; SUZUKI, MICHIYO ; TERASHIMA, SHIRO ; KIMURA, YOSHIKAZU</creator><creatorcontrib>ABE, RUMIKO ; MATSUMOTO, TERUYO ; SUZUKI, MICHIYO ; TERASHIMA, SHIRO ; KIMURA, YOSHIKAZU</creatorcontrib><description>A process for producing an anthracycline derivative represented by the general formula:where R1 is an acyl group, each of X1 and X2 is a hydrogen atom, a methoxy group, a hydroxyl group, a halogen atom or a lower alkyl group, each of Y1 and Y2 is a hydrogen atom, an alkoxy group or a hydroxyl group, and Z is a hydrogen atom or a protected hydroxyl group, which comprises reacting an anthracyclinone derivative represented by the general formula:where R is a hydrogen atom or a trialkylsilyl group, and X1, X2, Y1, Y2 and Z are as defined above, with a 1-acylsugar derivative represented by the general formula:where R2 is an acyl group and R1 is as defined above, in the presence of a silyl sulfonic acid derivative represented by the general formula:where each of R3, R4 and R5 is an alkyl group and A is an alkyl group, an aryl group, a polyfluoroalkyl group or a hydrogen atom.</description><edition>4</edition><language>eng</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; DERIVATIVES THEREOF ; METALLURGY ; NUCLEIC ACIDS ; NUCLEOSIDES ; NUCLEOTIDES ; ORGANIC CHEMISTRY ; SUGARS</subject><creationdate>1988</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19881026&DB=EPODOC&CC=EP&NR=0143323B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19881026&DB=EPODOC&CC=EP&NR=0143323B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ABE, RUMIKO</creatorcontrib><creatorcontrib>MATSUMOTO, TERUYO</creatorcontrib><creatorcontrib>SUZUKI, MICHIYO</creatorcontrib><creatorcontrib>TERASHIMA, SHIRO</creatorcontrib><creatorcontrib>KIMURA, YOSHIKAZU</creatorcontrib><title>PROCESS FOR AN ANTHRACYCLINE DERIVATIVE, AND AN ANTHRACYCLINONE DERIVATIVE USEFUL FOR THE PROCESS</title><description>A process for producing an anthracycline derivative represented by the general formula:where R1 is an acyl group, each of X1 and X2 is a hydrogen atom, a methoxy group, a hydroxyl group, a halogen atom or a lower alkyl group, each of Y1 and Y2 is a hydrogen atom, an alkoxy group or a hydroxyl group, and Z is a hydrogen atom or a protected hydroxyl group, which comprises reacting an anthracyclinone derivative represented by the general formula:where R is a hydrogen atom or a trialkylsilyl group, and X1, X2, Y1, Y2 and Z are as defined above, with a 1-acylsugar derivative represented by the general formula:where R2 is an acyl group and R1 is as defined above, in the presence of a silyl sulfonic acid derivative represented by the general formula:where each of R3, R4 and R5 is an alkyl group and A is an alkyl group, an aryl group, a polyfluoroalkyl group or a hydrogen atom.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>CHEMISTRY</subject><subject>DERIVATIVES THEREOF</subject><subject>METALLURGY</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>SUGARS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1988</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZEgMCPJ3dg0OVnDzD1Jw9AOiEI8gR-dIZx9PP1cFF9cgzzDHEM8wVx2gjAu6An8UJQqhwa5uoT5gk0I8XBWgJvMwsKYl5hSn8kJpbgYFN9cQZw_d1IL8-NTigsTk1LzUknjXAANDE2NjI2MnQ2MilAAASuUzPQ</recordid><startdate>19881026</startdate><enddate>19881026</enddate><creator>ABE, RUMIKO</creator><creator>MATSUMOTO, TERUYO</creator><creator>SUZUKI, MICHIYO</creator><creator>TERASHIMA, SHIRO</creator><creator>KIMURA, YOSHIKAZU</creator><scope>EVB</scope></search><sort><creationdate>19881026</creationdate><title>PROCESS FOR AN ANTHRACYCLINE DERIVATIVE, AND AN ANTHRACYCLINONE DERIVATIVE USEFUL FOR THE PROCESS</title><author>ABE, RUMIKO ; MATSUMOTO, TERUYO ; SUZUKI, MICHIYO ; TERASHIMA, SHIRO ; KIMURA, YOSHIKAZU</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP0143323B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1988</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>CHEMISTRY</topic><topic>DERIVATIVES THEREOF</topic><topic>METALLURGY</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>SUGARS</topic><toplevel>online_resources</toplevel><creatorcontrib>ABE, RUMIKO</creatorcontrib><creatorcontrib>MATSUMOTO, TERUYO</creatorcontrib><creatorcontrib>SUZUKI, MICHIYO</creatorcontrib><creatorcontrib>TERASHIMA, SHIRO</creatorcontrib><creatorcontrib>KIMURA, YOSHIKAZU</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ABE, RUMIKO</au><au>MATSUMOTO, TERUYO</au><au>SUZUKI, MICHIYO</au><au>TERASHIMA, SHIRO</au><au>KIMURA, YOSHIKAZU</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROCESS FOR AN ANTHRACYCLINE DERIVATIVE, AND AN ANTHRACYCLINONE DERIVATIVE USEFUL FOR THE PROCESS</title><date>1988-10-26</date><risdate>1988</risdate><abstract>A process for producing an anthracycline derivative represented by the general formula:where R1 is an acyl group, each of X1 and X2 is a hydrogen atom, a methoxy group, a hydroxyl group, a halogen atom or a lower alkyl group, each of Y1 and Y2 is a hydrogen atom, an alkoxy group or a hydroxyl group, and Z is a hydrogen atom or a protected hydroxyl group, which comprises reacting an anthracyclinone derivative represented by the general formula:where R is a hydrogen atom or a trialkylsilyl group, and X1, X2, Y1, Y2 and Z are as defined above, with a 1-acylsugar derivative represented by the general formula:where R2 is an acyl group and R1 is as defined above, in the presence of a silyl sulfonic acid derivative represented by the general formula:where each of R3, R4 and R5 is an alkyl group and A is an alkyl group, an aryl group, a polyfluoroalkyl group or a hydrogen atom.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_EP0143323B1 |
| source | esp@cenet |
| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY DERIVATIVES THEREOF METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY SUGARS |
| title | PROCESS FOR AN ANTHRACYCLINE DERIVATIVE, AND AN ANTHRACYCLINONE DERIVATIVE USEFUL FOR THE PROCESS |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T11%3A27%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=ABE,%20RUMIKO&rft.date=1988-10-26&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EEP0143323B1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |