ERGOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL APPLICATION
Substituted ergolines of the formula and their acid addition salts, wherein the urea side chain in the 8-position can be in the d alpha - or beta -configuration, C2 C3 and C9 C10 are a CC single or C=C double bond, and R is hydrogen or NR'R'' wherein R'R'' is O2, H2, C1...
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| creator | SCHNEIDER, HERBERT-HANS KEHR, WOLFGANG HAFFER, GREGOR WACHTEL, HELMUT SAUER, GERHARD |
| description | Substituted ergolines of the formula and their acid addition salts, wherein the urea side chain in the 8-position can be in the d alpha - or beta -configuration, C2 C3 and C9 C10 are a CC single or C=C double bond, and R is hydrogen or NR'R'' wherein R'R'' is O2, H2, C1-4-dialkyl, or, together, they form a 3- to 9-membered ring, or R' and R'' individually are hydrogen, C1-4-alkyl, or C1-10--acyl, R1 is hydrogen, C1-4-alkyl, C1-10-acyl, C6-8-aryl, or C1-4-alkylsulfonyl, R2 is hydrogen or halogen if C2 C3 is a C=C double bond, or hydrogen if C2 C3 is a CC single bond, R6 is C1-4-alkyl, show a pronounced effect on the central nervous system and are suitable, for example, as antidepressants, neuroleptics, or antihypertensives. |
| format | Patent |
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KEHR, WOLFGANG ; HAFFER, GREGOR ; WACHTEL, HELMUT ; SAUER, GERHARD</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP0118848B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; ger</language><creationdate>1992</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SCHNEIDER, HERBERT-HANS</creatorcontrib><creatorcontrib>KEHR, WOLFGANG</creatorcontrib><creatorcontrib>HAFFER, GREGOR</creatorcontrib><creatorcontrib>WACHTEL, HELMUT</creatorcontrib><creatorcontrib>SAUER, GERHARD</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SCHNEIDER, HERBERT-HANS</au><au>KEHR, WOLFGANG</au><au>HAFFER, GREGOR</au><au>WACHTEL, HELMUT</au><au>SAUER, GERHARD</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ERGOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL APPLICATION</title><date>1992-02-19</date><risdate>1992</risdate><abstract>Substituted ergolines of the formula and their acid addition salts, wherein the urea side chain in the 8-position can be in the d alpha - or beta -configuration, C2 C3 and C9 C10 are a CC single or C=C double bond, and R is hydrogen or NR'R'' wherein R'R'' is O2, H2, C1-4-dialkyl, or, together, they form a 3- to 9-membered ring, or R' and R'' individually are hydrogen, C1-4-alkyl, or C1-10--acyl, R1 is hydrogen, C1-4-alkyl, C1-10-acyl, C6-8-aryl, or C1-4-alkylsulfonyl, R2 is hydrogen or halogen if C2 C3 is a C=C double bond, or hydrogen if C2 C3 is a CC single bond, R6 is C1-4-alkyl, show a pronounced effect on the central nervous system and are suitable, for example, as antidepressants, neuroleptics, or antihypertensives.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | ERGOLINE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR PHARMACEUTICAL APPLICATION |
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