A PROCESS FOR THE PREPARATION OF INSULIN DERIVATIVES
Des derives d'insuline sont prepares en une seule etape en echangeant l'acide amine a terminaison C de la chaine B dans une insuline par le traitement avec une enzyme proteolitique, telle la tripsine, en presence d'un exces d'un acide amine, par exemple la L-treonine, avec un gro...
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| creator | ANDRESEN, FINN HEDE BALSCHMIDT, PER |
| description | Des derives d'insuline sont prepares en une seule etape en echangeant l'acide amine a terminaison C de la chaine B dans une insuline par le traitement avec une enzyme proteolitique, telle la tripsine, en presence d'un exces d'un acide amine, par exemple la L-treonine, avec un groupe carboxyle protege et en presence d'un solvant organique, apres quoi le groupe de protection carboxylique est facultativement separe.
Insulin derivatives are prepared in one step by exchanging the C-terminal amino acid of the B-chain in an insulin by treatment with a proteolytic enzyme, such as trypsin, in the presence of an excess of an amino acid, e.g. L-threonine, with protected carboxyl group and in the presence of an organic solvent, whereafter the carboxyl protecting group is optionally split off. |
| format | Patent |
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Insulin derivatives are prepared in one step by exchanging the C-terminal amino acid of the B-chain in an insulin by treatment with a proteolytic enzyme, such as trypsin, in the presence of an excess of an amino acid, e.g. L-threonine, with protected carboxyl group and in the presence of an organic solvent, whereafter the carboxyl protecting group is optionally split off.</description><language>eng ; fre ; ger</language><subject>BEER ; BIOCHEMISTRY ; CHEMISTRY ; ENZYMOLOGY ; FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE ; METALLURGY ; MICROBIOLOGY ; MUTATION OR GENETIC ENGINEERING ; ORGANIC CHEMISTRY ; PEPTIDES ; SPIRITS ; VINEGAR ; WINE</subject><creationdate>1983</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19830525&DB=EPODOC&CC=EP&NR=0079362A1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25543,76294</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19830525&DB=EPODOC&CC=EP&NR=0079362A1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>ANDRESEN, FINN HEDE</creatorcontrib><creatorcontrib>BALSCHMIDT, PER</creatorcontrib><title>A PROCESS FOR THE PREPARATION OF INSULIN DERIVATIVES</title><description>Des derives d'insuline sont prepares en une seule etape en echangeant l'acide amine a terminaison C de la chaine B dans une insuline par le traitement avec une enzyme proteolitique, telle la tripsine, en presence d'un exces d'un acide amine, par exemple la L-treonine, avec un groupe carboxyle protege et en presence d'un solvant organique, apres quoi le groupe de protection carboxylique est facultativement separe.
Insulin derivatives are prepared in one step by exchanging the C-terminal amino acid of the B-chain in an insulin by treatment with a proteolytic enzyme, such as trypsin, in the presence of an excess of an amino acid, e.g. L-threonine, with protected carboxyl group and in the presence of an organic solvent, whereafter the carboxyl protecting group is optionally split off.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>ENZYMOLOGY</subject><subject>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1983</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDBxVAgI8nd2DQ5WcPMPUgjxcAXyXQMcgxxDPP39FPzdFDz9gkN9PP0UXFyDPMOAomGuwTwMrGmJOcWpvFCam0HBzTXE2UM3tSA_PrW4IDE5NS-1JN41wMDA3NLYzMjR0JgIJQB3aCcD</recordid><startdate>19830525</startdate><enddate>19830525</enddate><creator>ANDRESEN, FINN HEDE</creator><creator>BALSCHMIDT, PER</creator><scope>EVB</scope></search><sort><creationdate>19830525</creationdate><title>A PROCESS FOR THE PREPARATION OF INSULIN DERIVATIVES</title><author>ANDRESEN, FINN HEDE ; BALSCHMIDT, PER</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP0079362A13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng ; fre ; ger</language><creationdate>1983</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>ENZYMOLOGY</topic><topic>FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>ANDRESEN, FINN HEDE</creatorcontrib><creatorcontrib>BALSCHMIDT, PER</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ANDRESEN, FINN HEDE</au><au>BALSCHMIDT, PER</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>A PROCESS FOR THE PREPARATION OF INSULIN DERIVATIVES</title><date>1983-05-25</date><risdate>1983</risdate><abstract>Des derives d'insuline sont prepares en une seule etape en echangeant l'acide amine a terminaison C de la chaine B dans une insuline par le traitement avec une enzyme proteolitique, telle la tripsine, en presence d'un exces d'un acide amine, par exemple la L-treonine, avec un groupe carboxyle protege et en presence d'un solvant organique, apres quoi le groupe de protection carboxylique est facultativement separe.
Insulin derivatives are prepared in one step by exchanging the C-terminal amino acid of the B-chain in an insulin by treatment with a proteolytic enzyme, such as trypsin, in the presence of an excess of an amino acid, e.g. L-threonine, with protected carboxyl group and in the presence of an organic solvent, whereafter the carboxyl protecting group is optionally split off.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY ENZYMOLOGY FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIREDCHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERSFROM A RACEMIC MIXTURE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES SPIRITS VINEGAR WINE |
| title | A PROCESS FOR THE PREPARATION OF INSULIN DERIVATIVES |
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