NEW 1-BENZYL-3,4-DIHYDRO-ISOQUINOLINE DERIVATIVE
The invention relates to the new 6,7-diethoxy-1-(4-ethoxy-3-hydroxy-benzyl)-3,4-dihydro-isoquinoline of the Formula I and physiologically acceptable salts thereof. The compound of the Formula I and salts thereof can be prepared by hydrolysing a compound of the general Formula VI (wherein R is a grou...
Gespeichert in:
| Hauptverfasser: | , , , , , , |
|---|---|
| Format: | Patent |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | |
|---|---|
| container_issue | |
| container_start_page | |
| container_title | |
| container_volume | |
| creator | SZEKERES, LASZLO PAPP, GYULA SZANTAY, CSABA UDVARY, EVA GYORI, PETER DAVID, AGOSTON KALAUS, GYORGY |
| description | The invention relates to the new 6,7-diethoxy-1-(4-ethoxy-3-hydroxy-benzyl)-3,4-dihydro-isoquinoline of the Formula I and physiologically acceptable salts thereof. The compound of the Formula I and salts thereof can be prepared by hydrolysing a compound of the general Formula VI (wherein R is a group removable by hydrogenolysis) preferably a benzyl group and R is an alkyl group having 1-6 carbon atoms), reacting the compound of the general Formula V thus obtained (wherein R is as stated above) with an amine of the general Formula IV or a salt thereof in the presence of a catalyst, subjecting the amide of the general Formula III thus obtained (wherein R is as stated above) to ring-closure and subjecting the compound of the General Formula II (wherein R is as stated above) or a salt thereof thus obtained to hydrogenolysis and if desired converting the compound of the Formula I thus obtained into a physiologically acceptable salt thereof or setting free the same from its salt. |
| format | Patent |
| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_EP0067711B1</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>EP0067711B1</sourcerecordid><originalsourceid>FETCH-epo_espacenet_EP0067711B13</originalsourceid><addsrcrecordid>eNrjZDDwcw1XMNR1cvWLivTRNdYx0XXx9Ih0CfLX9Qz2Dwz19PP38fRzVXBxDfIMcwzxDHPlYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxrgEGBmbm5oaGTobGRCgBANHbJcg</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>NEW 1-BENZYL-3,4-DIHYDRO-ISOQUINOLINE DERIVATIVE</title><source>esp@cenet</source><creator>SZEKERES, LASZLO ; PAPP, GYULA ; SZANTAY, CSABA ; UDVARY, EVA ; GYORI, PETER ; DAVID, AGOSTON ; KALAUS, GYORGY</creator><creatorcontrib>SZEKERES, LASZLO ; PAPP, GYULA ; SZANTAY, CSABA ; UDVARY, EVA ; GYORI, PETER ; DAVID, AGOSTON ; KALAUS, GYORGY</creatorcontrib><description>The invention relates to the new 6,7-diethoxy-1-(4-ethoxy-3-hydroxy-benzyl)-3,4-dihydro-isoquinoline of the Formula I and physiologically acceptable salts thereof. The compound of the Formula I and salts thereof can be prepared by hydrolysing a compound of the general Formula VI (wherein R is a group removable by hydrogenolysis) preferably a benzyl group and R is an alkyl group having 1-6 carbon atoms), reacting the compound of the general Formula V thus obtained (wherein R is as stated above) with an amine of the general Formula IV or a salt thereof in the presence of a catalyst, subjecting the amide of the general Formula III thus obtained (wherein R is as stated above) to ring-closure and subjecting the compound of the General Formula II (wherein R is as stated above) or a salt thereof thus obtained to hydrogenolysis and if desired converting the compound of the Formula I thus obtained into a physiologically acceptable salt thereof or setting free the same from its salt.</description><edition>4</edition><language>eng</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1986</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19861001&DB=EPODOC&CC=EP&NR=0067711B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19861001&DB=EPODOC&CC=EP&NR=0067711B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SZEKERES, LASZLO</creatorcontrib><creatorcontrib>PAPP, GYULA</creatorcontrib><creatorcontrib>SZANTAY, CSABA</creatorcontrib><creatorcontrib>UDVARY, EVA</creatorcontrib><creatorcontrib>GYORI, PETER</creatorcontrib><creatorcontrib>DAVID, AGOSTON</creatorcontrib><creatorcontrib>KALAUS, GYORGY</creatorcontrib><title>NEW 1-BENZYL-3,4-DIHYDRO-ISOQUINOLINE DERIVATIVE</title><description>The invention relates to the new 6,7-diethoxy-1-(4-ethoxy-3-hydroxy-benzyl)-3,4-dihydro-isoquinoline of the Formula I and physiologically acceptable salts thereof. The compound of the Formula I and salts thereof can be prepared by hydrolysing a compound of the general Formula VI (wherein R is a group removable by hydrogenolysis) preferably a benzyl group and R is an alkyl group having 1-6 carbon atoms), reacting the compound of the general Formula V thus obtained (wherein R is as stated above) with an amine of the general Formula IV or a salt thereof in the presence of a catalyst, subjecting the amide of the general Formula III thus obtained (wherein R is as stated above) to ring-closure and subjecting the compound of the General Formula II (wherein R is as stated above) or a salt thereof thus obtained to hydrogenolysis and if desired converting the compound of the Formula I thus obtained into a physiologically acceptable salt thereof or setting free the same from its salt.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1986</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDDwcw1XMNR1cvWLivTRNdYx0XXx9Ih0CfLX9Qz2Dwz19PP38fRzVXBxDfIMcwzxDHPlYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxrgEGBmbm5oaGTobGRCgBANHbJcg</recordid><startdate>19861001</startdate><enddate>19861001</enddate><creator>SZEKERES, LASZLO</creator><creator>PAPP, GYULA</creator><creator>SZANTAY, CSABA</creator><creator>UDVARY, EVA</creator><creator>GYORI, PETER</creator><creator>DAVID, AGOSTON</creator><creator>KALAUS, GYORGY</creator><scope>EVB</scope></search><sort><creationdate>19861001</creationdate><title>NEW 1-BENZYL-3,4-DIHYDRO-ISOQUINOLINE DERIVATIVE</title><author>SZEKERES, LASZLO ; PAPP, GYULA ; SZANTAY, CSABA ; UDVARY, EVA ; GYORI, PETER ; DAVID, AGOSTON ; KALAUS, GYORGY</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_EP0067711B13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>eng</language><creationdate>1986</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SZEKERES, LASZLO</creatorcontrib><creatorcontrib>PAPP, GYULA</creatorcontrib><creatorcontrib>SZANTAY, CSABA</creatorcontrib><creatorcontrib>UDVARY, EVA</creatorcontrib><creatorcontrib>GYORI, PETER</creatorcontrib><creatorcontrib>DAVID, AGOSTON</creatorcontrib><creatorcontrib>KALAUS, GYORGY</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SZEKERES, LASZLO</au><au>PAPP, GYULA</au><au>SZANTAY, CSABA</au><au>UDVARY, EVA</au><au>GYORI, PETER</au><au>DAVID, AGOSTON</au><au>KALAUS, GYORGY</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>NEW 1-BENZYL-3,4-DIHYDRO-ISOQUINOLINE DERIVATIVE</title><date>1986-10-01</date><risdate>1986</risdate><abstract>The invention relates to the new 6,7-diethoxy-1-(4-ethoxy-3-hydroxy-benzyl)-3,4-dihydro-isoquinoline of the Formula I and physiologically acceptable salts thereof. The compound of the Formula I and salts thereof can be prepared by hydrolysing a compound of the general Formula VI (wherein R is a group removable by hydrogenolysis) preferably a benzyl group and R is an alkyl group having 1-6 carbon atoms), reacting the compound of the general Formula V thus obtained (wherein R is as stated above) with an amine of the general Formula IV or a salt thereof in the presence of a catalyst, subjecting the amide of the general Formula III thus obtained (wherein R is as stated above) to ring-closure and subjecting the compound of the General Formula II (wherein R is as stated above) or a salt thereof thus obtained to hydrogenolysis and if desired converting the compound of the Formula I thus obtained into a physiologically acceptable salt thereof or setting free the same from its salt.</abstract><edition>4</edition><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | |
| ispartof | |
| issn | |
| language | eng |
| recordid | cdi_epo_espacenet_EP0067711B1 |
| source | esp@cenet |
| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | NEW 1-BENZYL-3,4-DIHYDRO-ISOQUINOLINE DERIVATIVE |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-04T16%3A20%3A40IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-epo_EVB&rft_val_fmt=info:ofi/fmt:kev:mtx:patent&rft.genre=patent&rft.au=SZEKERES,%20LASZLO&rft.date=1986-10-01&rft_id=info:doi/&rft_dat=%3Cepo_EVB%3EEP0067711B1%3C/epo_EVB%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_id=info:pmid/&rfr_iscdi=true |