3-Deazaadenosine and pharmaceutical compositions containing it
Adenosine derivatives for inhibition of immune response are disclosed. Adenosine derivatives of formula (I) Wherein R is amino or lower alkyl amino; R is hydrogen or an aliphatic carboxylic acid residue; and R is hydrogen, aliphatic carboxylic acid residue or a phosphoric acid residue, are useful as...
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| creator | ZIMMERMAN, THOMAS PAUL WOLBERG, GERALD |
| description | Adenosine derivatives for inhibition of immune response are disclosed. Adenosine derivatives of formula (I) Wherein R is amino or lower alkyl amino; R is hydrogen or an aliphatic carboxylic acid residue; and R is hydrogen, aliphatic carboxylic acid residue or a phosphoric acid residue, are useful as inhibitora of immune response. The activity is potentiated by derivatives of homocysteine and homocystine. Particularty useful is 3-deaza-adenosine both alone and in combination with @-homocysteine thiolacetone, Pharmaceutical formulations of compounds of formula (I) alone and with potentiators are provided. |
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Adenosine derivatives of formula (I) Wherein R is amino or lower alkyl amino; R is hydrogen or an aliphatic carboxylic acid residue; and R is hydrogen, aliphatic carboxylic acid residue or a phosphoric acid residue, are useful as inhibitora of immune response. The activity is potentiated by derivatives of homocysteine and homocystine. 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Adenosine derivatives of formula (I) Wherein R is amino or lower alkyl amino; R is hydrogen or an aliphatic carboxylic acid residue; and R is hydrogen, aliphatic carboxylic acid residue or a phosphoric acid residue, are useful as inhibitora of immune response. The activity is potentiated by derivatives of homocysteine and homocystine. Particularty useful is 3-deaza-adenosine both alone and in combination with @-homocysteine thiolacetone, Pharmaceutical formulations of compounds of formula (I) alone and with potentiators are provided.</abstract><oa>free_for_read</oa></addata></record> |
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| language | eng ; fre ; ger |
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| subjects | CHEMISTRY DERIVATIVES THEREOF HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SUGARS |
| title | 3-Deazaadenosine and pharmaceutical compositions containing it |
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