AMINOQUINOLONAS SUSTITUIDAS COMO INHIBIDORES DE DGK ALFA PARA LA ACTIVACIÓN INMUNE
La presente invención se refiere a compuestos de aminoquinolona de la fórmula general (I) : (conforme a figura constante en resumen de memoria técnica) (I), donde R1, R2, R3, R4, R5, R6, R7, R8 y n han sido definidos en la memoria, métodos de preparación de dichos compuestos, compuestos intermedios...
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| creator | KOSEMUND, Dirk HERBERT, Simon Anthony STÖCKIGT, Detlef OFFRINGA, Rienk NGUYEN, Thi MEIER, Robin Michael WERBECK, Nicolas WORTMANN, Lars LECHNER, Christian BÖMER, Ulf KOBER, Christina PETERSEN, Kirstin SCHMEES, Norbert GREES, Mareike KIRCHHOFF, Dennis KERSCHGENS, Isabel Patrizia |
| description | La presente invención se refiere a compuestos de aminoquinolona de la fórmula general (I) : (conforme a figura constante en resumen de memoria técnica) (I), donde R1, R2, R3, R4, R5, R6, R7, R8 y n han sido definidos en la memoria, métodos de preparación de dichos compuestos, compuestos intermedios de utilidad para preparar dichos compuestos, composiciones farmacéuticas y combinaciones que comprenden dichos compuestos y el uso de dichos compuestos para la fabricación de composiciones farmacéuticas para el tratamiento y/o profilaxis de enfermedades, en particular de trastornos regulados por diacilglicerol quinasa alfa, como agente único o en combinación con otros principios activos.
The present invention covers aminoquinolone compounds of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8 and n are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients. |
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The present invention covers aminoquinolone compounds of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8 and n are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.</description><language>spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2022</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220630&DB=EPODOC&CC=EC&NR=SP22041839A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20220630&DB=EPODOC&CC=EC&NR=SP22041839A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KOSEMUND, Dirk</creatorcontrib><creatorcontrib>HERBERT, Simon Anthony</creatorcontrib><creatorcontrib>STÖCKIGT, Detlef</creatorcontrib><creatorcontrib>OFFRINGA, Rienk</creatorcontrib><creatorcontrib>NGUYEN, Thi</creatorcontrib><creatorcontrib>MEIER, Robin Michael</creatorcontrib><creatorcontrib>WERBECK, Nicolas</creatorcontrib><creatorcontrib>WORTMANN, Lars</creatorcontrib><creatorcontrib>LECHNER, Christian</creatorcontrib><creatorcontrib>BÖMER, Ulf</creatorcontrib><creatorcontrib>KOBER, Christina</creatorcontrib><creatorcontrib>PETERSEN, Kirstin</creatorcontrib><creatorcontrib>SCHMEES, Norbert</creatorcontrib><creatorcontrib>GREES, Mareike</creatorcontrib><creatorcontrib>KIRCHHOFF, Dennis</creatorcontrib><creatorcontrib>KERSCHGENS, Isabel Patrizia</creatorcontrib><title>AMINOQUINOLONAS SUSTITUIDAS COMO INHIBIDORES DE DGK ALFA PARA LA ACTIVACIÓN INMUNE</title><description>La presente invención se refiere a compuestos de aminoquinolona de la fórmula general (I) : (conforme a figura constante en resumen de memoria técnica) (I), donde R1, R2, R3, R4, R5, R6, R7, R8 y n han sido definidos en la memoria, métodos de preparación de dichos compuestos, compuestos intermedios de utilidad para preparar dichos compuestos, composiciones farmacéuticas y combinaciones que comprenden dichos compuestos y el uso de dichos compuestos para la fabricación de composiciones farmacéuticas para el tratamiento y/o profilaxis de enfermedades, en particular de trastornos regulados por diacilglicerol quinasa alfa, como agente único o en combinación con otros principios activos.
The present invention covers aminoquinolone compounds of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8 and n are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2022</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZAh29PX08w8MBRI-_n6OwQrBocEhniGhni5AtrO_r7-Cp5-Hp5Oni3-Qa7CCi6uCi7u3gqOPm6NCgGOQo4KPo4Kjc4hnmKOz5-HJfkC1vqF-rjwMrGmJOcWpvFCam0HJzTXE2UM3tSA_PrW4IDE5NS-1JN7VOTjAyMjAxNDC2NLRmChFAMJGMV8</recordid><startdate>20220630</startdate><enddate>20220630</enddate><creator>KOSEMUND, Dirk</creator><creator>HERBERT, Simon Anthony</creator><creator>STÖCKIGT, Detlef</creator><creator>OFFRINGA, Rienk</creator><creator>NGUYEN, Thi</creator><creator>MEIER, Robin Michael</creator><creator>WERBECK, Nicolas</creator><creator>WORTMANN, Lars</creator><creator>LECHNER, Christian</creator><creator>BÖMER, Ulf</creator><creator>KOBER, Christina</creator><creator>PETERSEN, Kirstin</creator><creator>SCHMEES, Norbert</creator><creator>GREES, Mareike</creator><creator>KIRCHHOFF, Dennis</creator><creator>KERSCHGENS, Isabel Patrizia</creator><scope>EVB</scope></search><sort><creationdate>20220630</creationdate><title>AMINOQUINOLONAS SUSTITUIDAS COMO INHIBIDORES DE DGK ALFA PARA LA ACTIVACIÓN INMUNE</title><author>KOSEMUND, Dirk ; HERBERT, Simon Anthony ; STÖCKIGT, Detlef ; OFFRINGA, Rienk ; NGUYEN, Thi ; MEIER, Robin Michael ; WERBECK, Nicolas ; WORTMANN, Lars ; LECHNER, Christian ; BÖMER, Ulf ; KOBER, Christina ; PETERSEN, Kirstin ; SCHMEES, Norbert ; GREES, Mareike ; KIRCHHOFF, Dennis ; KERSCHGENS, Isabel Patrizia</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ECSP22041839A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2022</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>KOSEMUND, Dirk</creatorcontrib><creatorcontrib>HERBERT, Simon Anthony</creatorcontrib><creatorcontrib>STÖCKIGT, Detlef</creatorcontrib><creatorcontrib>OFFRINGA, Rienk</creatorcontrib><creatorcontrib>NGUYEN, Thi</creatorcontrib><creatorcontrib>MEIER, Robin Michael</creatorcontrib><creatorcontrib>WERBECK, Nicolas</creatorcontrib><creatorcontrib>WORTMANN, Lars</creatorcontrib><creatorcontrib>LECHNER, Christian</creatorcontrib><creatorcontrib>BÖMER, Ulf</creatorcontrib><creatorcontrib>KOBER, Christina</creatorcontrib><creatorcontrib>PETERSEN, Kirstin</creatorcontrib><creatorcontrib>SCHMEES, Norbert</creatorcontrib><creatorcontrib>GREES, Mareike</creatorcontrib><creatorcontrib>KIRCHHOFF, Dennis</creatorcontrib><creatorcontrib>KERSCHGENS, Isabel Patrizia</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KOSEMUND, Dirk</au><au>HERBERT, Simon Anthony</au><au>STÖCKIGT, Detlef</au><au>OFFRINGA, Rienk</au><au>NGUYEN, Thi</au><au>MEIER, Robin Michael</au><au>WERBECK, Nicolas</au><au>WORTMANN, Lars</au><au>LECHNER, Christian</au><au>BÖMER, Ulf</au><au>KOBER, Christina</au><au>PETERSEN, Kirstin</au><au>SCHMEES, Norbert</au><au>GREES, Mareike</au><au>KIRCHHOFF, Dennis</au><au>KERSCHGENS, Isabel Patrizia</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>AMINOQUINOLONAS SUSTITUIDAS COMO INHIBIDORES DE DGK ALFA PARA LA ACTIVACIÓN INMUNE</title><date>2022-06-30</date><risdate>2022</risdate><abstract>La presente invención se refiere a compuestos de aminoquinolona de la fórmula general (I) : (conforme a figura constante en resumen de memoria técnica) (I), donde R1, R2, R3, R4, R5, R6, R7, R8 y n han sido definidos en la memoria, métodos de preparación de dichos compuestos, compuestos intermedios de utilidad para preparar dichos compuestos, composiciones farmacéuticas y combinaciones que comprenden dichos compuestos y el uso de dichos compuestos para la fabricación de composiciones farmacéuticas para el tratamiento y/o profilaxis de enfermedades, en particular de trastornos regulados por diacilglicerol quinasa alfa, como agente único o en combinación con otros principios activos.
The present invention covers aminoquinolone compounds of general formula (I), in which R1, R2, R3, R4, R5, R6, R7, R8 and n are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment and/or prophylaxis of diseases, in particular of diacylglycerol kinase alpha regulated disorders, as a sole agent or in combination with other active ingredients.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | AMINOQUINOLONAS SUSTITUIDAS COMO INHIBIDORES DE DGK ALFA PARA LA ACTIVACIÓN INMUNE |
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