FORMA CRISTALINA DE 2-(2,6-DICLOROFENIL)-1-[(1S,3R)-3-(HIDROXIMETIL)-5-(3-HIDROXI-3-METILBUTIL)-1-METIL-3,4-DIHIDROISOQUINOLIN-2(1H)-IL]ETANONA PARA EL TRATAMIENTO
La presente invención se refiere a una forma cristalina de 2-(2,6-diclorofenil)-1-[(1S,3R)-3-(hidroximetil)-5-(3-hidroxi-3-metilbutil)-1-metil-3,4-dihidroisoquinolin-2(1H)-il]etanona, y composiciones farmacéuticas de la misma. La invención además proporciona métodos para usar una forma cristalina de...
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| creator | STEPHENSON, Gregory Alan |
| description | La presente invención se refiere a una forma cristalina de 2-(2,6-diclorofenil)-1-[(1S,3R)-3-(hidroximetil)-5-(3-hidroxi-3-metilbutil)-1-metil-3,4-dihidroisoquinolin-2(1H)-il]etanona, y composiciones farmacéuticas de la misma. La invención además proporciona métodos para usar una forma cristalina de 2-(2,6-diclorofenil)-1-[(1S,3R)-3-(hidroximetil)-5-(3-hidroxi-3-metilbutil)-1-metil-3,4-dihidroisoquinolin-2(1H)-il]etanona para tratar deterioro cognitivo asociado con la enfermedad de Parkinson o esquizofrenia.
The invention provides a crystalline form of 2-(2,6-dichlorophenyl)-1-[(1S,3R)-3-(hydroxymethyl)-5-(3-hydroxy-3-methylbutyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl]ethanone, and pharmaceutical compositions thereof. The invention further provides methods of using a crystalline form of 2-(2,6-dichlorophenyl)-1-[(1S,3R)-3-(hydroxymethyl)-5-(3-hydroxy-3-methylbutyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl]ethanone to treat cognitive impairment associated with Parkinson's disease or schizophrenia. |
| format | Patent |
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The invention provides a crystalline form of 2-(2,6-dichlorophenyl)-1-[(1S,3R)-3-(hydroxymethyl)-5-(3-hydroxy-3-methylbutyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl]ethanone, and pharmaceutical compositions thereof. The invention further provides methods of using a crystalline form of 2-(2,6-dichlorophenyl)-1-[(1S,3R)-3-(hydroxymethyl)-5-(3-hydroxy-3-methylbutyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl]ethanone to treat cognitive impairment associated with Parkinson's disease or schizophrenia.</description><language>spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2018</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180531&DB=EPODOC&CC=EC&NR=SP18030976A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20180531&DB=EPODOC&CC=EC&NR=SP18030976A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>STEPHENSON, Gregory Alan</creatorcontrib><title>FORMA CRISTALINA DE 2-(2,6-DICLOROFENIL)-1-[(1S,3R)-3-(HIDROXIMETIL)-5-(3-HIDROXI-3-METILBUTIL)-1-METIL-3,4-DIHIDROISOQUINOLIN-2(1H)-IL]ETANONA PARA EL TRATAMIENTO</title><description>La presente invención se refiere a una forma cristalina de 2-(2,6-diclorofenil)-1-[(1S,3R)-3-(hidroximetil)-5-(3-hidroxi-3-metilbutil)-1-metil-3,4-dihidroisoquinolin-2(1H)-il]etanona, y composiciones farmacéuticas de la misma. La invención además proporciona métodos para usar una forma cristalina de 2-(2,6-diclorofenil)-1-[(1S,3R)-3-(hidroximetil)-5-(3-hidroxi-3-metilbutil)-1-metil-3,4-dihidroisoquinolin-2(1H)-il]etanona para tratar deterioro cognitivo asociado con la enfermedad de Parkinson o esquizofrenia.
The invention provides a crystalline form of 2-(2,6-dichlorophenyl)-1-[(1S,3R)-3-(hydroxymethyl)-5-(3-hydroxy-3-methylbutyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl]ethanone, and pharmaceutical compositions thereof. The invention further provides methods of using a crystalline form of 2-(2,6-dichlorophenyl)-1-[(1S,3R)-3-(hydroxymethyl)-5-(3-hydroxy-3-methylbutyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl]ethanone to treat cognitive impairment associated with Parkinson's disease or schizophrenia.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2018</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNTUsKwjAQ7caFqHcIrlLogG38Lsc2pQNpomkKgkgRiStRQW_kRa3VA7h6vH8_eOXGlshSS5VDRRpZJlkCPInmkFGqjDW51KRCiGHP4yoSNgQBvKDMmh2V0n28GXABP6l1O3Vdu2-tYyCiaTvYZagy25q0ae8g4XERAqmDdKhNe79Bi0wq5iw6LElqZ4ZB73y8PPzoh4NgnEuXFuDvt8Y_7seTv_pnI9NqEy8nYrJazFH8FXoDGBdETQ</recordid><startdate>20180531</startdate><enddate>20180531</enddate><creator>STEPHENSON, Gregory Alan</creator><scope>EVB</scope></search><sort><creationdate>20180531</creationdate><title>FORMA CRISTALINA DE 2-(2,6-DICLOROFENIL)-1-[(1S,3R)-3-(HIDROXIMETIL)-5-(3-HIDROXI-3-METILBUTIL)-1-METIL-3,4-DIHIDROISOQUINOLIN-2(1H)-IL]ETANONA PARA EL TRATAMIENTO</title><author>STEPHENSON, Gregory Alan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ECSP18030976A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2018</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>STEPHENSON, Gregory Alan</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>STEPHENSON, Gregory Alan</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>FORMA CRISTALINA DE 2-(2,6-DICLOROFENIL)-1-[(1S,3R)-3-(HIDROXIMETIL)-5-(3-HIDROXI-3-METILBUTIL)-1-METIL-3,4-DIHIDROISOQUINOLIN-2(1H)-IL]ETANONA PARA EL TRATAMIENTO</title><date>2018-05-31</date><risdate>2018</risdate><abstract>La presente invención se refiere a una forma cristalina de 2-(2,6-diclorofenil)-1-[(1S,3R)-3-(hidroximetil)-5-(3-hidroxi-3-metilbutil)-1-metil-3,4-dihidroisoquinolin-2(1H)-il]etanona, y composiciones farmacéuticas de la misma. La invención además proporciona métodos para usar una forma cristalina de 2-(2,6-diclorofenil)-1-[(1S,3R)-3-(hidroximetil)-5-(3-hidroxi-3-metilbutil)-1-metil-3,4-dihidroisoquinolin-2(1H)-il]etanona para tratar deterioro cognitivo asociado con la enfermedad de Parkinson o esquizofrenia.
The invention provides a crystalline form of 2-(2,6-dichlorophenyl)-1-[(1S,3R)-3-(hydroxymethyl)-5-(3-hydroxy-3-methylbutyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl]ethanone, and pharmaceutical compositions thereof. The invention further provides methods of using a crystalline form of 2-(2,6-dichlorophenyl)-1-[(1S,3R)-3-(hydroxymethyl)-5-(3-hydroxy-3-methylbutyl)-1-methyl-3,4-dihydroisoquinolin-2(1H)-yl]ethanone to treat cognitive impairment associated with Parkinson's disease or schizophrenia.</abstract><oa>free_for_read</oa></addata></record> |
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| language | spa |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | FORMA CRISTALINA DE 2-(2,6-DICLOROFENIL)-1-[(1S,3R)-3-(HIDROXIMETIL)-5-(3-HIDROXI-3-METILBUTIL)-1-METIL-3,4-DIHIDROISOQUINOLIN-2(1H)-IL]ETANONA PARA EL TRATAMIENTO |
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