COMPUESTOS Y SU USO COMO INHIBIDORES DE BACE
La presente invención se refiere a compuestos de fórmula (I) y sus composiciones farmacéuticas. Asimismo, la presente invención se refiere a métodos terapéuticos para el tratamiento y/o la prevención de patologías relacionadas con A?, como síndrome de Down, angiopatía ?-amiloide como, a modo no taxa...
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| creator | SÖDERMAN, PETER SWAHN, BRITT-MARIE RAKOS, LASZLO KOLMODIN, KARIN NYLÖF, MARTIN VON BERG, STEFAN ÖHBERG, LISELOTTE SANDBERG, LARS SEHGELMEBLE, FERNANDO CSJERNYIK, GABOR KERS, ANNIKA KARLSTRÖM, SOFIA |
| description | La presente invención se refiere a compuestos de fórmula (I) y sus composiciones farmacéuticas. Asimismo, la presente invención se refiere a métodos terapéuticos para el tratamiento y/o la prevención de patologías relacionadas con A?, como síndrome de Down, angiopatía ?-amiloide como, a modo no taxativo, angiopatía amiloide cerebral o hemorragia cerebral hereditaria, trastornos asociados con el deterioro cognitivo como, a modo no taxativo, MCI ("deterioro cognitivo leve"), mal de Alzheimer, pérdida de memoria, síntomas de déficit de atención asociados con mal de Alzheimer, neurodegeneración asociada con enfermedades como mal de Alzheimer o demencia, incluida demencia de origen vascular y degenerativo mixto, demencia presenil, demencia senil y demencia asociada con mal de Parkinson, parálisis supranuclear progresiva o degeneración corticobasal.
The present invention relates to compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Aß-related pathologies such as Down's syndrome, ß- amyloid angiopathy such as, but not limited to, cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI ("mild cognitive impairment"), Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease. |
| format | Patent |
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The present invention relates to compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Aß-related pathologies such as Down's syndrome, ß- amyloid angiopathy such as, but not limited to, cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI ("mild cognitive impairment"), Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease.</description><language>spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2013</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130830&DB=EPODOC&CC=EC&NR=SP13012708A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76318</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130830&DB=EPODOC&CC=EC&NR=SP13012708A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SÖDERMAN, PETER</creatorcontrib><creatorcontrib>SWAHN, BRITT-MARIE</creatorcontrib><creatorcontrib>RAKOS, LASZLO</creatorcontrib><creatorcontrib>KOLMODIN, KARIN</creatorcontrib><creatorcontrib>NYLÖF, MARTIN</creatorcontrib><creatorcontrib>VON BERG, STEFAN</creatorcontrib><creatorcontrib>ÖHBERG, LISELOTTE</creatorcontrib><creatorcontrib>SANDBERG, LARS</creatorcontrib><creatorcontrib>SEHGELMEBLE, FERNANDO</creatorcontrib><creatorcontrib>CSJERNYIK, GABOR</creatorcontrib><creatorcontrib>KERS, ANNIKA</creatorcontrib><creatorcontrib>KARLSTRÖM, SOFIA</creatorcontrib><title>COMPUESTOS Y SU USO COMO INHIBIDORES DE BACE</title><description>La presente invención se refiere a compuestos de fórmula (I) y sus composiciones farmacéuticas. Asimismo, la presente invención se refiere a métodos terapéuticos para el tratamiento y/o la prevención de patologías relacionadas con A?, como síndrome de Down, angiopatía ?-amiloide como, a modo no taxativo, angiopatía amiloide cerebral o hemorragia cerebral hereditaria, trastornos asociados con el deterioro cognitivo como, a modo no taxativo, MCI ("deterioro cognitivo leve"), mal de Alzheimer, pérdida de memoria, síntomas de déficit de atención asociados con mal de Alzheimer, neurodegeneración asociada con enfermedades como mal de Alzheimer o demencia, incluida demencia de origen vascular y degenerativo mixto, demencia presenil, demencia senil y demencia asociada con mal de Parkinson, parálisis supranuclear progresiva o degeneración corticobasal.
The present invention relates to compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Aß-related pathologies such as Down's syndrome, ß- amyloid angiopathy such as, but not limited to, cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI ("mild cognitive impairment"), Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2013</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZNBx9vcNCHUNDvEPVohUCA5VCA32VwCK-St4-nl4Onm6-Ae5Biu4uCo4OTq78jCwpiXmFKfyQmluBiU31xBnD93Ugvz41OKCxOTUvNSSeFfn4ABDYwNDI3MDC0djohQBANfmJbE</recordid><startdate>20130830</startdate><enddate>20130830</enddate><creator>SÖDERMAN, PETER</creator><creator>SWAHN, BRITT-MARIE</creator><creator>RAKOS, LASZLO</creator><creator>KOLMODIN, KARIN</creator><creator>NYLÖF, MARTIN</creator><creator>VON BERG, STEFAN</creator><creator>ÖHBERG, LISELOTTE</creator><creator>SANDBERG, LARS</creator><creator>SEHGELMEBLE, FERNANDO</creator><creator>CSJERNYIK, GABOR</creator><creator>KERS, ANNIKA</creator><creator>KARLSTRÖM, SOFIA</creator><scope>EVB</scope></search><sort><creationdate>20130830</creationdate><title>COMPUESTOS Y SU USO COMO INHIBIDORES DE BACE</title><author>SÖDERMAN, PETER ; SWAHN, BRITT-MARIE ; RAKOS, LASZLO ; KOLMODIN, KARIN ; NYLÖF, MARTIN ; VON BERG, STEFAN ; ÖHBERG, LISELOTTE ; SANDBERG, LARS ; SEHGELMEBLE, FERNANDO ; CSJERNYIK, GABOR ; KERS, ANNIKA ; KARLSTRÖM, SOFIA</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ECSP13012708A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2013</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SÖDERMAN, PETER</creatorcontrib><creatorcontrib>SWAHN, BRITT-MARIE</creatorcontrib><creatorcontrib>RAKOS, LASZLO</creatorcontrib><creatorcontrib>KOLMODIN, KARIN</creatorcontrib><creatorcontrib>NYLÖF, MARTIN</creatorcontrib><creatorcontrib>VON BERG, STEFAN</creatorcontrib><creatorcontrib>ÖHBERG, LISELOTTE</creatorcontrib><creatorcontrib>SANDBERG, LARS</creatorcontrib><creatorcontrib>SEHGELMEBLE, FERNANDO</creatorcontrib><creatorcontrib>CSJERNYIK, GABOR</creatorcontrib><creatorcontrib>KERS, ANNIKA</creatorcontrib><creatorcontrib>KARLSTRÖM, SOFIA</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SÖDERMAN, PETER</au><au>SWAHN, BRITT-MARIE</au><au>RAKOS, LASZLO</au><au>KOLMODIN, KARIN</au><au>NYLÖF, MARTIN</au><au>VON BERG, STEFAN</au><au>ÖHBERG, LISELOTTE</au><au>SANDBERG, LARS</au><au>SEHGELMEBLE, FERNANDO</au><au>CSJERNYIK, GABOR</au><au>KERS, ANNIKA</au><au>KARLSTRÖM, SOFIA</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>COMPUESTOS Y SU USO COMO INHIBIDORES DE BACE</title><date>2013-08-30</date><risdate>2013</risdate><abstract>La presente invención se refiere a compuestos de fórmula (I) y sus composiciones farmacéuticas. Asimismo, la presente invención se refiere a métodos terapéuticos para el tratamiento y/o la prevención de patologías relacionadas con A?, como síndrome de Down, angiopatía ?-amiloide como, a modo no taxativo, angiopatía amiloide cerebral o hemorragia cerebral hereditaria, trastornos asociados con el deterioro cognitivo como, a modo no taxativo, MCI ("deterioro cognitivo leve"), mal de Alzheimer, pérdida de memoria, síntomas de déficit de atención asociados con mal de Alzheimer, neurodegeneración asociada con enfermedades como mal de Alzheimer o demencia, incluida demencia de origen vascular y degenerativo mixto, demencia presenil, demencia senil y demencia asociada con mal de Parkinson, parálisis supranuclear progresiva o degeneración corticobasal.
The present invention relates to compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Aß-related pathologies such as Down's syndrome, ß- amyloid angiopathy such as, but not limited to, cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI ("mild cognitive impairment"), Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | COMPUESTOS Y SU USO COMO INHIBIDORES DE BACE |
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