FORMULACIONES AUTOEMULSIONANTES DE INHIBIDORES DE LA PROTEÍNA DE TRANSFERENCIA DE COLESTERIL ÉSTER
Inhibidores de CETP que tienen mejor solubilidad y biodisponibilidad en un vehículo lipófilo que comprende un aceite digerible, un disolvente lipófilo o un tensioactivo. Tales composiciones preferidas son auto emulsionantes o automicroemulsionantes y comprenden 1. un inhibidor de CETP; 2. un codisol...
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| creator | LOMBARDO FRANCO PERLMAN MICHAEL GUMKOWSKI MICHAEL JON MURDANDE SHARAD BALASAHEB |
| description | Inhibidores de CETP que tienen mejor solubilidad y biodisponibilidad en un vehículo lipófilo que comprende un aceite digerible, un disolvente lipófilo o un tensioactivo. Tales composiciones preferidas son auto emulsionantes o automicroemulsionantes y comprenden 1. un inhibidor de CETP; 2. un codisolvente; 3. Un tensioactivo que tiene un HLB de 1 a 8; 4. un tensioactivo que tiene un HLB de 8 a 20; y 5. opcionalmente, un aceite digerible.
CETP Inhibitors have improved solubility and bioavailability in a lipophilic vehicle comprising a digestible oil, a lipophilic solvent, or a surfactant. Preferred such compositions are self-emulsifying or self-microemulsifying, and comprise 1. a CETP inhibitor; 2. a cosolvent; 3. a surfactant having an HLB of 1 to 8; 4. a surfactant having an HLB of over 8 to 20; and 5. optionally, a digestible oil. |
| format | Patent |
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CETP Inhibitors have improved solubility and bioavailability in a lipophilic vehicle comprising a digestible oil, a lipophilic solvent, or a surfactant. Preferred such compositions are self-emulsifying or self-microemulsifying, and comprise 1. a CETP inhibitor; 2. a cosolvent; 3. a surfactant having an HLB of 1 to 8; 4. a surfactant having an HLB of over 8 to 20; and 5. optionally, a digestible oil.</description><edition>6</edition><language>spa</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040128&DB=EPODOC&CC=EC&NR=SP034875A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,776,881,25542,76516</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20040128&DB=EPODOC&CC=EC&NR=SP034875A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>LOMBARDO FRANCO</creatorcontrib><creatorcontrib>PERLMAN MICHAEL</creatorcontrib><creatorcontrib>GUMKOWSKI MICHAEL JON</creatorcontrib><creatorcontrib>MURDANDE SHARAD BALASAHEB</creatorcontrib><title>FORMULACIONES AUTOEMULSIONANTES DE INHIBIDORES DE LA PROTEÍNA DE TRANSFERENCIA DE COLESTERIL ÉSTER</title><description>Inhibidores de CETP que tienen mejor solubilidad y biodisponibilidad en un vehículo lipófilo que comprende un aceite digerible, un disolvente lipófilo o un tensioactivo. Tales composiciones preferidas son auto emulsionantes o automicroemulsionantes y comprenden 1. un inhibidor de CETP; 2. un codisolvente; 3. Un tensioactivo que tiene un HLB de 1 a 8; 4. un tensioactivo que tiene un HLB de 8 a 20; y 5. opcionalmente, un aceite digerible.
CETP Inhibitors have improved solubility and bioavailability in a lipophilic vehicle comprising a digestible oil, a lipophilic solvent, or a surfactant. Preferred such compositions are self-emulsifying or self-microemulsifying, and comprise 1. a CETP inhibitor; 2. a cosolvent; 3. a surfactant having an HLB of 1 to 8; 4. a surfactant having an HLB of over 8 to 20; and 5. optionally, a digestible oil.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZEhx8w_yDfVxdPb093MNVnAMDfF3BfKDgVxHvxCgiIurgqefh6eTp4t_EITr46gQEOQf4nq4188RxA8JcvQLdnMNcvVz9gQLOPv7uAaHuAZ5-igc7gQxeBhY0xJzilN5oTQ3g4Kba4izh25qQX58anFBYnJqXmpJvKtzcICBsYmFuamjMRFKAMD-Njk</recordid><startdate>20040128</startdate><enddate>20040128</enddate><creator>LOMBARDO FRANCO</creator><creator>PERLMAN MICHAEL</creator><creator>GUMKOWSKI MICHAEL JON</creator><creator>MURDANDE SHARAD BALASAHEB</creator><scope>EVB</scope></search><sort><creationdate>20040128</creationdate><title>FORMULACIONES AUTOEMULSIONANTES DE INHIBIDORES DE LA PROTEÍNA DE TRANSFERENCIA DE COLESTERIL ÉSTER</title><author>LOMBARDO FRANCO ; PERLMAN MICHAEL ; GUMKOWSKI MICHAEL JON ; MURDANDE SHARAD BALASAHEB</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_ECSP034875A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>spa</language><creationdate>2004</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>LOMBARDO FRANCO</creatorcontrib><creatorcontrib>PERLMAN MICHAEL</creatorcontrib><creatorcontrib>GUMKOWSKI MICHAEL JON</creatorcontrib><creatorcontrib>MURDANDE SHARAD BALASAHEB</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>LOMBARDO FRANCO</au><au>PERLMAN MICHAEL</au><au>GUMKOWSKI MICHAEL JON</au><au>MURDANDE SHARAD BALASAHEB</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>FORMULACIONES AUTOEMULSIONANTES DE INHIBIDORES DE LA PROTEÍNA DE TRANSFERENCIA DE COLESTERIL ÉSTER</title><date>2004-01-28</date><risdate>2004</risdate><abstract>Inhibidores de CETP que tienen mejor solubilidad y biodisponibilidad en un vehículo lipófilo que comprende un aceite digerible, un disolvente lipófilo o un tensioactivo. Tales composiciones preferidas son auto emulsionantes o automicroemulsionantes y comprenden 1. un inhibidor de CETP; 2. un codisolvente; 3. Un tensioactivo que tiene un HLB de 1 a 8; 4. un tensioactivo que tiene un HLB de 8 a 20; y 5. opcionalmente, un aceite digerible.
CETP Inhibitors have improved solubility and bioavailability in a lipophilic vehicle comprising a digestible oil, a lipophilic solvent, or a surfactant. Preferred such compositions are self-emulsifying or self-microemulsifying, and comprise 1. a CETP inhibitor; 2. a cosolvent; 3. a surfactant having an HLB of 1 to 8; 4. a surfactant having an HLB of over 8 to 20; and 5. optionally, a digestible oil.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | FORMULACIONES AUTOEMULSIONANTES DE INHIBIDORES DE LA PROTEÍNA DE TRANSFERENCIA DE COLESTERIL ÉSTER |
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