N-ARYL PIPERIDINE SUBSTITUTED BIPHENYLCARBOXAMIDES AS INHIBITORS OF APOLIPOPROTEIN B SECRETION

N-ARYL PIPERIDINE SUBSTITUTED BIPHENYLCARBOXAMIDES AS INHIBITORS OF APOLIPOPROTEIN B SECRETION

N-aryl piperidine substituted biphenylcarboxamides compounds of formula (I) methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes. The compounds...

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Bibliographische Detailangaben
Hauptverfasser: ROEVENS PETER, WALTER, MARIA, MEERPOEL LIEVEN, BACKX LEO, JACOBUS, JOSEF
Format: Patent
Sprache:eng ; rus
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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Zusammenfassung:N-aryl piperidine substituted biphenylcarboxamides compounds of formula (I) methods for preparing such compounds, pharmaceutical compositions comprising said compounds as well as the use of said compounds as a medicine for the treatment of hyperlipidemia, obesity and type II diabetes. The compounds act as inhibitors of apolipoprotein B. Предложены N-арилпиперидинзамещенные бифенилкарбоксамидные соединения формулы (I), способы получения таких соединений, фармацевтические композиции, содержащие такие соединения, а также применение указанных соединений в качестве медикамента для лечения гиперлипидемии, ожирения и диабета II типа. Соединения действуют как ингибиторы аполипопротеина В.