FREMGANGSMAADE TIL FREMSTILLING AF N-(TETRAZOL-5-YL) PROSTAGLANDIN-CARBOXAMIDER ELLER SALTE DERAF
The invention provides compounds of the formula or pharmacologically acceptable salts thereof, wherein: A is ethylene of cis-vinylene; B is ethylene trans-vinylene; Y is hydrogen or hydroxy; G is CH2Ar, CH2OAr or CRZ(CH2)3CH3; Ar is phenyl, fluorophenyl, chlorophenyl, methylphenyl, ethylphenyl, meth...
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| creator | SCHAAF T K |
| description | The invention provides compounds of the formula or pharmacologically acceptable salts thereof, wherein: A is ethylene of cis-vinylene; B is ethylene trans-vinylene; Y is hydrogen or hydroxy; G is CH2Ar, CH2OAr or CRZ(CH2)3CH3; Ar is phenyl, fluorophenyl, chlorophenyl, methylphenyl, ethylphenyl, methoxyphenyl, ethoxyphenyl, biphenyl or trifluoromethylphenyl; R is hydrogen or methyl; and Z is hydrogen or methyl. These compounds can be divided into three classes, each class having different and selective biological activities depending on the substituent in the bottom side chain. Compounds having a C-16 phenyl or substituted phenyl substituent have antiulcer activity, compounds having a C-16 phenoxy or substituted phenoxy substituent have fertility control activity and compounds having a C-15 n-pentyl, 1-methylpentyl, or 1,1-dimethylpentenyl substituent have bronchodilator or fertility control activity. |
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These compounds can be divided into three classes, each class having different and selective biological activities depending on the substituent in the bottom side chain. Compounds having a C-16 phenyl or substituted phenyl substituent have antiulcer activity, compounds having a C-16 phenoxy or substituted phenoxy substituent have fertility control activity and compounds having a C-15 n-pentyl, 1-methylpentyl, or 1,1-dimethylpentenyl substituent have bronchodilator or fertility control activity.</description><edition>2</edition><language>dan</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>1979</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19790717&DB=EPODOC&CC=DK&NR=523378A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19790717&DB=EPODOC&CC=DK&NR=523378A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SCHAAF T K</creatorcontrib><title>FREMGANGSMAADE TIL FREMSTILLING AF N-(TETRAZOL-5-YL) PROSTAGLANDIN-CARBOXAMIDER ELLER SALTE DERAF</title><description>The invention provides compounds of the formula or pharmacologically acceptable salts thereof, wherein: A is ethylene of cis-vinylene; B is ethylene trans-vinylene; Y is hydrogen or hydroxy; G is CH2Ar, CH2OAr or CRZ(CH2)3CH3; Ar is phenyl, fluorophenyl, chlorophenyl, methylphenyl, ethylphenyl, methoxyphenyl, ethoxyphenyl, biphenyl or trifluoromethylphenyl; R is hydrogen or methyl; and Z is hydrogen or methyl. These compounds can be divided into three classes, each class having different and selective biological activities depending on the substituent in the bottom side chain. Compounds having a C-16 phenyl or substituted phenyl substituent have antiulcer activity, compounds having a C-16 phenoxy or substituted phenoxy substituent have fertility control activity and compounds having a C-15 n-pentyl, 1-methylpentyl, or 1,1-dimethylpentenyl substituent have bronchodilator or fertility control activity.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1979</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqFirEKAjEQRNNYiPoLsqUWaTwObdfLJgb3EklSqM0RJFaiB-f_4wn2NjNvHjMVWQdqDToTW0RFkCzDV8UR2DoDqMHJVaIU8OpZ1vLCazgFHxMaRqeskw2GvT9jaxUFIOYxI3IiGDfquZjc82Moi1_PxFJTag6y9K-uDH2-lWd5d-pYb6pqu8Pq7-EDbgEyQA</recordid><startdate>19790717</startdate><enddate>19790717</enddate><creator>SCHAAF T K</creator><scope>EVB</scope></search><sort><creationdate>19790717</creationdate><title>FREMGANGSMAADE TIL FREMSTILLING AF N-(TETRAZOL-5-YL) PROSTAGLANDIN-CARBOXAMIDER ELLER SALTE DERAF</title><author>SCHAAF T K</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_DK523378A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>dan</language><creationdate>1979</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SCHAAF T K</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SCHAAF T K</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>FREMGANGSMAADE TIL FREMSTILLING AF N-(TETRAZOL-5-YL) PROSTAGLANDIN-CARBOXAMIDER ELLER SALTE DERAF</title><date>1979-07-17</date><risdate>1979</risdate><abstract>The invention provides compounds of the formula or pharmacologically acceptable salts thereof, wherein: A is ethylene of cis-vinylene; B is ethylene trans-vinylene; Y is hydrogen or hydroxy; G is CH2Ar, CH2OAr or CRZ(CH2)3CH3; Ar is phenyl, fluorophenyl, chlorophenyl, methylphenyl, ethylphenyl, methoxyphenyl, ethoxyphenyl, biphenyl or trifluoromethylphenyl; R is hydrogen or methyl; and Z is hydrogen or methyl. These compounds can be divided into three classes, each class having different and selective biological activities depending on the substituent in the bottom side chain. Compounds having a C-16 phenyl or substituted phenyl substituent have antiulcer activity, compounds having a C-16 phenoxy or substituted phenoxy substituent have fertility control activity and compounds having a C-15 n-pentyl, 1-methylpentyl, or 1,1-dimethylpentenyl substituent have bronchodilator or fertility control activity.</abstract><edition>2</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | FREMGANGSMAADE TIL FREMSTILLING AF N-(TETRAZOL-5-YL) PROSTAGLANDIN-CARBOXAMIDER ELLER SALTE DERAF |
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