Novel GLP-1-analoger

Novel GLP-1-analoger

The present disclosure pertains to novel Glucagon like Peptide-1 (GLP-1) (7-37) analogs having an amino acid sequence with Leu or Ile at the C-terminal. The new analogs are potent GLP-1 agonists with reduced adverse effect and improved duration of action. The present disclosure further relates to ac...

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Hauptverfasser: PANDYA, Kunal, ZALAWADIA, Rishit Mansukhlal, PATEL, Brijeshkumar, SHAHI, Pradeep Dinesh, THENNATI, Rajamannar, NAGARAJA, Ravishankara Madavati, SONI, Krunal Harishbhai, TIWARI, Abhishek, BURADE, Vinod Sampatrao, CHATURVEDI, Nishith, JOSHI, Dhiren Rameshchandra, NATARAJAN, Muthukumaran, PATEL, Vipulkumar Shankarbhai
Format: Patent
Sprache:dan
Schlagworte:
CHEMISTRY
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
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Zusammenfassung:The present disclosure pertains to novel Glucagon like Peptide-1 (GLP-1) (7-37) analogs having an amino acid sequence with Leu or Ile at the C-terminal. The new analogs are potent GLP-1 agonists with reduced adverse effect and improved duration of action. The present disclosure further relates to acylated derivatives of the new analogs which have further improved potency and duration of action and are suitable for oral administration. The analogs of present disclosure may be useful in treatment of diabetes and obesity.