SVAMPESTAMMER, DER OMFATTER FÆNOTYPER MED FORBEDRET PROTEINPRODUKTIVITET, OG FREMGANGSMÅDER DERMED

SVAMPESTAMMER, DER OMFATTER FÆNOTYPER MED FORBEDRET PROTEINPRODUKTIVITET, OG FREMGANGSMÅDER DERMED

The present disclosure is generally related to modified filamentous fungal strains (cells) comprising enhanced protein productivity phenotypes, wherein such modified strains are particularly well-suited for growth in submerged cultures (e.g., large-scale production of proteins for industrial/commerc...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: CHEN, Zhongqiang, LIU, Chuanbin, WARD, Michael, BODIE, Elizabeth A
Format: Patent
Sprache:dan
Schlagworte:
BEER
BIOCHEMISTRY
CHEMISTRY
COMPOSITIONS THEREOF
CULTURE MEDIA
ENZYMOLOGY
METALLURGY
MICROBIOLOGY
MICROORGANISMS OR ENZYMES
MUTATION OR GENETIC ENGINEERING
PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS
SPIRITS
VINEGAR
WINE
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Beschreibung
Zusammenfassung:The present disclosure is generally related to modified filamentous fungal strains (cells) comprising enhanced protein productivity phenotypes, wherein such modified strains are particularly well-suited for growth in submerged cultures (e.g., large-scale production of proteins for industrial/commercial applications). Thus, certain embodiments of the disclosure are related to such variant (modified) strains of filamentous fungus derived (obtained) from parental strains comprising a gene encoding a native GEF1 protein, wherein the variant strain comprises a genetic modification which disrupts or deletes a gene encoding a native GEF1 protein, wherein the variant strain comprises an increased protein productivity phenotype (i.e., relative to the parental strain) when grown/cultivated/fermented under the same conditions.