PYRAZOLO[1,5-A]PYRIMIDINER, DER ER NYTTIGE SOM INHIBITORER AF ATR-KINASE TIL BEHANDLING AF KRÆFTSYGDOMME
The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this inv...
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| creator | PIERARD, Francoise KAY, David JIMENEZ, Juan-Miguel ODONNELL, Michael KNEGTEL, Roland TWIN, Heather CHARRIER, Jean-Damien STORCK, Pierre-Henri AHMAD, Nadia DURRANT, Steven PINDER, Joanne STUDLEY, John BOYALL, Dean PANESAR, Maninder SHAW, David FRAYSSE, Damine MIDDLETON, Donald ETXEBARRIA I JARDI, Gorka DAVIS, Chris DAVIS, Rebecca |
| description | The present invention relates to compounds useful as inhibitors of ATR protein kinase. The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I:or a pharmaceutically acceptable salt, wherein the variables are as devined herein.Moreover, The compounds of this invention have formula I-A:or a pharmaceutically acceptable salt, wherein the variables are as defined herein. |
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The invention also relates to pharmaceutically acceptable compositions comprising the compounds of this invention; methods of treating of various diseases, disorders, and conditions using the compounds of this invention; processes for preparing the compounds of this invention; intermediates for the preparation of the compounds of this invention; and methods of using the compounds in in vitro applications, such as the study of kinases in biological and pathological phenomena; the study of intracellular signal transduction pathways mediated by such kinases; and the comparative evaluation of new kinase inhibitors.The compounds of this invention have formula I:or a pharmaceutically acceptable salt, wherein the variables are as devined herein.Moreover, The compounds of this invention have formula I-A:or a pharmaceutically acceptable salt, wherein the variables are as defined herein.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | PYRAZOLO[1,5-A]PYRIMIDINER, DER ER NYTTIGE SOM INHIBITORER AF ATR-KINASE TIL BEHANDLING AF KRÆFTSYGDOMME |
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