HIDTIL UKENDTE MODIFICEREDE T-CELLERECEPTORER OG IMMUNTERAPI MED ANVENDELSE DERAF
The present invention pertains to antigen recognizing constructs against COL6A3 antigens. The invention in particular provides novel engineered T cell receptor (TCR) based molecules which are selective and specific for the tumor expressing antigen COL6A3. The TCR of the invention, and COL6A3 antigen...
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| creator | HOFMANN, Martin WAGNER, Claudia MAURER, Dominik BUNK, Sebastian ALTEN, Leonie HUTT, Meike UNVERDORBEN, Felix |
| description | The present invention pertains to antigen recognizing constructs against COL6A3 antigens. The invention in particular provides novel engineered T cell receptor (TCR) based molecules which are selective and specific for the tumor expressing antigen COL6A3. The TCR of the invention, and COL6A3 antigen binding fragments derived therefrom, are of use for the diagnosis, treatment and prevention of COL6A3 expressing cancerous diseases. Further provided are nucleic acids encoding the antigen recognizing constructs of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen recognizing constructs and pharmaceutical compositions comprising the compounds of the invention. |
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The invention in particular provides novel engineered T cell receptor (TCR) based molecules which are selective and specific for the tumor expressing antigen COL6A3. The TCR of the invention, and COL6A3 antigen binding fragments derived therefrom, are of use for the diagnosis, treatment and prevention of COL6A3 expressing cancerous diseases. 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Further provided are nucleic acids encoding the antigen recognizing constructs of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen recognizing constructs and pharmaceutical compositions comprising the compounds of the invention.</description><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS THEREOF</subject><subject>CULTURE MEDIA</subject><subject>ENZYMOLOGY</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MICROORGANISMS OR ENZYMES</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2024</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNqNizsKwkAURdNYiLqH5wICSgjBMsy7Y4bMJ44vtiHIWIkG4v4xhQuwuofDuevs0hgWY6lv4VlALrDRRiGCQZIrWLuwQichIlI4k3Gu94JYd4YcmGp_W66wVxAvVm-z1WN8zmn320221xDV5Gl6D2mexnt6pc_AbVEdqmN5EimLf5ovqfkvuQ</recordid><startdate>20240826</startdate><enddate>20240826</enddate><creator>HOFMANN, Martin</creator><creator>WAGNER, Claudia</creator><creator>MAURER, Dominik</creator><creator>BUNK, Sebastian</creator><creator>ALTEN, Leonie</creator><creator>HUTT, Meike</creator><creator>UNVERDORBEN, Felix</creator><scope>EVB</scope></search><sort><creationdate>20240826</creationdate><title>HIDTIL UKENDTE MODIFICEREDE T-CELLERECEPTORER OG IMMUNTERAPI MED ANVENDELSE DERAF</title><author>HOFMANN, Martin ; WAGNER, Claudia ; MAURER, Dominik ; BUNK, Sebastian ; ALTEN, Leonie ; HUTT, Meike ; UNVERDORBEN, Felix</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_DK3707159TT53</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>dan</language><creationdate>2024</creationdate><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS THEREOF</topic><topic>CULTURE MEDIA</topic><topic>ENZYMOLOGY</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MICROORGANISMS OR ENZYMES</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>HOFMANN, Martin</creatorcontrib><creatorcontrib>WAGNER, Claudia</creatorcontrib><creatorcontrib>MAURER, Dominik</creatorcontrib><creatorcontrib>BUNK, Sebastian</creatorcontrib><creatorcontrib>ALTEN, Leonie</creatorcontrib><creatorcontrib>HUTT, Meike</creatorcontrib><creatorcontrib>UNVERDORBEN, Felix</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>HOFMANN, Martin</au><au>WAGNER, Claudia</au><au>MAURER, Dominik</au><au>BUNK, Sebastian</au><au>ALTEN, Leonie</au><au>HUTT, Meike</au><au>UNVERDORBEN, Felix</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>HIDTIL UKENDTE MODIFICEREDE T-CELLERECEPTORER OG IMMUNTERAPI MED ANVENDELSE DERAF</title><date>2024-08-26</date><risdate>2024</risdate><abstract>The present invention pertains to antigen recognizing constructs against COL6A3 antigens. The invention in particular provides novel engineered T cell receptor (TCR) based molecules which are selective and specific for the tumor expressing antigen COL6A3. The TCR of the invention, and COL6A3 antigen binding fragments derived therefrom, are of use for the diagnosis, treatment and prevention of COL6A3 expressing cancerous diseases. Further provided are nucleic acids encoding the antigen recognizing constructs of the invention, vectors comprising these nucleic acids, recombinant cells expressing the antigen recognizing constructs and pharmaceutical compositions comprising the compounds of the invention.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | BEER BIOCHEMISTRY CHEMISTRY COMPOSITIONS THEREOF CULTURE MEDIA ENZYMOLOGY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MICROORGANISMS OR ENZYMES MUTATION OR GENETIC ENGINEERING ORGANIC CHEMISTRY PEPTIDES PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PROPAGATING, PRESERVING OR MAINTAINING MICROORGANISMS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS VINEGAR WINE |
| title | HIDTIL UKENDTE MODIFICEREDE T-CELLERECEPTORER OG IMMUNTERAPI MED ANVENDELSE DERAF |
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