Nye polymorfe former af minocyclinbase og fremgangsmåder til fremstilling deraf

Nye polymorfe former af minocyclinbase og fremgangsmåder til fremstilling deraf

The present invention concerns new forms of crystalline minocycline base. In particular, two new crystalline polymorphic forms, designated Form IV and Form V of minocycline base are provided. These are characterized by XRD, FTIR and TGA. Processes for preparing the new polymorphic forms and their us...

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Hauptverfasser: TEN FIGAS, Gloria, MENDES, Zita, CACELA, Constança, FERNANDEZ CASARES, Ana
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Sprache:dan
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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creator TEN FIGAS, Gloria
MENDES, Zita
CACELA, Constança
FERNANDEZ CASARES, Ana
description The present invention concerns new forms of crystalline minocycline base. In particular, two new crystalline polymorphic forms, designated Form IV and Form V of minocycline base are provided. These are characterized by XRD, FTIR and TGA. Processes for preparing the new polymorphic forms and their use in pharmaceutical compositions are also provided. Form IV and form V are prepared by dissolving and/or suspending minocycline base in an organic solvent followed by crystallization.
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In particular, two new crystalline polymorphic forms, designated Form IV and Form V of minocycline base are provided. These are characterized by XRD, FTIR and TGA. Processes for preparing the new polymorphic forms and their use in pharmaceutical compositions are also provided. 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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
title Nye polymorfe former af minocyclinbase og fremgangsmåder til fremstilling deraf
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