Fremgangsmåde til fremstillingen af 3-substituerede (indol-1-yl)-eddikesyreestere

Fremgangsmåde til fremstillingen af 3-substituerede (indol-1-yl)-eddikesyreestere

The invention relates to an industrial scale process for the preparation of a compound of general formula (I): (Formula (I)) wherein R1, R2 and R3 are as defined herein. The process comprises reacting compounds of general formulae (II) and (III): (formulae (II), (III)) in the presence of a Lewis aci...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: BLANCHET, Sylvie, TONNEL, Jaques, DEWAELE, Guillaume Léonard Pierre
Format: Patent
Sprache:dan
Schlagworte:
CHEMISTRY
HETEROCYCLIC COMPOUNDS
METALLURGY
ORGANIC CHEMISTRY
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Beschreibung
Zusammenfassung:The invention relates to an industrial scale process for the preparation of a compound of general formula (I): (Formula (I)) wherein R1, R2 and R3 are as defined herein. The process comprises reacting compounds of general formulae (II) and (III): (formulae (II), (III)) in the presence of a Lewis acid followed by a reduction with triethylsilane.