Nyt benzazepinderivat og farmaceutisk anvendelse deraf
An object of the present invention is to provide a compound having a V2 receptor agonistic activity. Provided is a pharmaceutical composition which contains, as an active ingredient, a compound represented by the general formula (I) described below: [wherein R 1 is the formula described below: (wher...
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creator | KUNO, Yuka KURUMAZUKA, Daisuke OKABE, Morio KATAOKA, Hiroyo MIYAZAWA, Toshiyuki NAGANO, Hiroki TAKAHASHI, Naoki TAKEUCHI, Mitsuaki KASUGAI, Nobuyoshi FUJIEDA, Hiroki SAKAI, Keita GOTOH, Izumi ASANO, Yukiyasu YAMADA, Yurie HARADA, Satoko IZUCHI, Toru KITAMOTO, Katsunori OHSAWA, Yasushi |
description | An object of the present invention is to provide a compound having a V2 receptor agonistic activity. Provided is a pharmaceutical composition which contains, as an active ingredient, a compound represented by the general formula (I) described below:
[wherein R 1 is the formula described below:
(wherein A is a lower alkylene group which may be substituted with a lower alkyl group, or the like; R 6 is a hydrogen atom, or the like; R 7 is a hydroxyl group, an aromatic heterocyclic group which may be substituted with a lower alkyl group, a carbamoyl group, or the like) ; R 2 is a hydrogen atom or a lower alkyl group; R 3 is a lower alkyl group which may be substituted with 1 to 3 fluorine atoms, or a halogen atom; R 4 is a five-membered aromatic monocyclic heterocyclic group, a five-membered non-aromatic monocyclic heterocyclic group, or the like, (provided that each of these heterocyclic groups contains at least one nitrogen atom and may be substituted with a lower alkyl group) ; and R 5 is a lower alkyl group, a halogen atom, or the like], or a pharmacologically acceptable salt thereof. |
format | Patent |
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[wherein R 1 is the formula described below:
(wherein A is a lower alkylene group which may be substituted with a lower alkyl group, or the like; R 6 is a hydrogen atom, or the like; R 7 is a hydroxyl group, an aromatic heterocyclic group which may be substituted with a lower alkyl group, a carbamoyl group, or the like) ; R 2 is a hydrogen atom or a lower alkyl group; R 3 is a lower alkyl group which may be substituted with 1 to 3 fluorine atoms, or a halogen atom; R 4 is a five-membered aromatic monocyclic heterocyclic group, a five-membered non-aromatic monocyclic heterocyclic group, or the like, (provided that each of these heterocyclic groups contains at least one nitrogen atom and may be substituted with a lower alkyl group) ; and R 5 is a lower alkyl group, a halogen atom, or the like], or a pharmacologically acceptable salt thereof.</description><language>dan</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2017</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170807&DB=EPODOC&CC=DK&NR=2940008T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25568,76551</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20170807&DB=EPODOC&CC=DK&NR=2940008T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>KUNO, Yuka</creatorcontrib><creatorcontrib>KURUMAZUKA, Daisuke</creatorcontrib><creatorcontrib>OKABE, Morio</creatorcontrib><creatorcontrib>KATAOKA, Hiroyo</creatorcontrib><creatorcontrib>MIYAZAWA, Toshiyuki</creatorcontrib><creatorcontrib>NAGANO, Hiroki</creatorcontrib><creatorcontrib>TAKAHASHI, Naoki</creatorcontrib><creatorcontrib>TAKEUCHI, Mitsuaki</creatorcontrib><creatorcontrib>KASUGAI, Nobuyoshi</creatorcontrib><creatorcontrib>FUJIEDA, Hiroki</creatorcontrib><creatorcontrib>SAKAI, Keita</creatorcontrib><creatorcontrib>GOTOH, Izumi</creatorcontrib><creatorcontrib>ASANO, Yukiyasu</creatorcontrib><creatorcontrib>YAMADA, Yurie</creatorcontrib><creatorcontrib>HARADA, Satoko</creatorcontrib><creatorcontrib>IZUCHI, Toru</creatorcontrib><creatorcontrib>KITAMOTO, Katsunori</creatorcontrib><creatorcontrib>OHSAWA, Yasushi</creatorcontrib><title>Nyt benzazepinderivat og farmaceutisk anvendelse deraf</title><description>An object of the present invention is to provide a compound having a V2 receptor agonistic activity. Provided is a pharmaceutical composition which contains, as an active ingredient, a compound represented by the general formula (I) described below:
[wherein R 1 is the formula described below:
(wherein A is a lower alkylene group which may be substituted with a lower alkyl group, or the like; R 6 is a hydrogen atom, or the like; R 7 is a hydroxyl group, an aromatic heterocyclic group which may be substituted with a lower alkyl group, a carbamoyl group, or the like) ; R 2 is a hydrogen atom or a lower alkyl group; R 3 is a lower alkyl group which may be substituted with 1 to 3 fluorine atoms, or a halogen atom; R 4 is a five-membered aromatic monocyclic heterocyclic group, a five-membered non-aromatic monocyclic heterocyclic group, or the like, (provided that each of these heterocyclic groups contains at least one nitrogen atom and may be substituted with a lower alkyl group) ; and R 5 is a lower alkyl group, a halogen atom, or the like], or a pharmacologically acceptable salt thereof.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2017</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDDzqyxRSErNq0qsSi3IzEtJLcosSyxRyE9XSEssyk1MTi0tySzOVkjMK0sFSuYUpyoAlSSm8TCwpiUCebxQmptB0c01xNlDN7UgPz61uACoMS-1JN7F28jSxMDAwCIkxNiYGDUA6PQudw</recordid><startdate>20170807</startdate><enddate>20170807</enddate><creator>KUNO, Yuka</creator><creator>KURUMAZUKA, Daisuke</creator><creator>OKABE, Morio</creator><creator>KATAOKA, Hiroyo</creator><creator>MIYAZAWA, Toshiyuki</creator><creator>NAGANO, Hiroki</creator><creator>TAKAHASHI, Naoki</creator><creator>TAKEUCHI, Mitsuaki</creator><creator>KASUGAI, Nobuyoshi</creator><creator>FUJIEDA, Hiroki</creator><creator>SAKAI, Keita</creator><creator>GOTOH, Izumi</creator><creator>ASANO, Yukiyasu</creator><creator>YAMADA, Yurie</creator><creator>HARADA, Satoko</creator><creator>IZUCHI, Toru</creator><creator>KITAMOTO, Katsunori</creator><creator>OHSAWA, Yasushi</creator><scope>EVB</scope></search><sort><creationdate>20170807</creationdate><title>Nyt benzazepinderivat og farmaceutisk anvendelse deraf</title><author>KUNO, Yuka ; KURUMAZUKA, Daisuke ; OKABE, Morio ; KATAOKA, Hiroyo ; MIYAZAWA, Toshiyuki ; NAGANO, Hiroki ; TAKAHASHI, Naoki ; TAKEUCHI, Mitsuaki ; KASUGAI, Nobuyoshi ; FUJIEDA, Hiroki ; SAKAI, Keita ; GOTOH, Izumi ; ASANO, Yukiyasu ; YAMADA, Yurie ; HARADA, Satoko ; IZUCHI, Toru ; KITAMOTO, Katsunori ; OHSAWA, Yasushi</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_DK2940008TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>dan</language><creationdate>2017</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>KUNO, Yuka</creatorcontrib><creatorcontrib>KURUMAZUKA, Daisuke</creatorcontrib><creatorcontrib>OKABE, Morio</creatorcontrib><creatorcontrib>KATAOKA, Hiroyo</creatorcontrib><creatorcontrib>MIYAZAWA, Toshiyuki</creatorcontrib><creatorcontrib>NAGANO, Hiroki</creatorcontrib><creatorcontrib>TAKAHASHI, Naoki</creatorcontrib><creatorcontrib>TAKEUCHI, Mitsuaki</creatorcontrib><creatorcontrib>KASUGAI, Nobuyoshi</creatorcontrib><creatorcontrib>FUJIEDA, Hiroki</creatorcontrib><creatorcontrib>SAKAI, Keita</creatorcontrib><creatorcontrib>GOTOH, Izumi</creatorcontrib><creatorcontrib>ASANO, Yukiyasu</creatorcontrib><creatorcontrib>YAMADA, Yurie</creatorcontrib><creatorcontrib>HARADA, Satoko</creatorcontrib><creatorcontrib>IZUCHI, Toru</creatorcontrib><creatorcontrib>KITAMOTO, Katsunori</creatorcontrib><creatorcontrib>OHSAWA, Yasushi</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>KUNO, Yuka</au><au>KURUMAZUKA, Daisuke</au><au>OKABE, Morio</au><au>KATAOKA, Hiroyo</au><au>MIYAZAWA, Toshiyuki</au><au>NAGANO, Hiroki</au><au>TAKAHASHI, Naoki</au><au>TAKEUCHI, Mitsuaki</au><au>KASUGAI, Nobuyoshi</au><au>FUJIEDA, Hiroki</au><au>SAKAI, Keita</au><au>GOTOH, Izumi</au><au>ASANO, Yukiyasu</au><au>YAMADA, Yurie</au><au>HARADA, Satoko</au><au>IZUCHI, Toru</au><au>KITAMOTO, Katsunori</au><au>OHSAWA, Yasushi</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Nyt benzazepinderivat og farmaceutisk anvendelse deraf</title><date>2017-08-07</date><risdate>2017</risdate><abstract>An object of the present invention is to provide a compound having a V2 receptor agonistic activity. Provided is a pharmaceutical composition which contains, as an active ingredient, a compound represented by the general formula (I) described below:
[wherein R 1 is the formula described below:
(wherein A is a lower alkylene group which may be substituted with a lower alkyl group, or the like; R 6 is a hydrogen atom, or the like; R 7 is a hydroxyl group, an aromatic heterocyclic group which may be substituted with a lower alkyl group, a carbamoyl group, or the like) ; R 2 is a hydrogen atom or a lower alkyl group; R 3 is a lower alkyl group which may be substituted with 1 to 3 fluorine atoms, or a halogen atom; R 4 is a five-membered aromatic monocyclic heterocyclic group, a five-membered non-aromatic monocyclic heterocyclic group, or the like, (provided that each of these heterocyclic groups contains at least one nitrogen atom and may be substituted with a lower alkyl group) ; and R 5 is a lower alkyl group, a halogen atom, or the like], or a pharmacologically acceptable salt thereof.</abstract><oa>free_for_read</oa></addata></record> |
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subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
title | Nyt benzazepinderivat og farmaceutisk anvendelse deraf |
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