Nyt benzazepinderivat og farmaceutisk anvendelse deraf

An object of the present invention is to provide a compound having a V2 receptor agonistic activity. Provided is a pharmaceutical composition which contains, as an active ingredient, a compound represented by the general formula (I) described below: [wherein R 1 is the formula described below: (wher...

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Hauptverfasser: KUNO, Yuka, KURUMAZUKA, Daisuke, OKABE, Morio, KATAOKA, Hiroyo, MIYAZAWA, Toshiyuki, NAGANO, Hiroki, TAKAHASHI, Naoki, TAKEUCHI, Mitsuaki, KASUGAI, Nobuyoshi, FUJIEDA, Hiroki, SAKAI, Keita, GOTOH, Izumi, ASANO, Yukiyasu, YAMADA, Yurie, HARADA, Satoko, IZUCHI, Toru, KITAMOTO, Katsunori, OHSAWA, Yasushi
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creator KUNO, Yuka
KURUMAZUKA, Daisuke
OKABE, Morio
KATAOKA, Hiroyo
MIYAZAWA, Toshiyuki
NAGANO, Hiroki
TAKAHASHI, Naoki
TAKEUCHI, Mitsuaki
KASUGAI, Nobuyoshi
FUJIEDA, Hiroki
SAKAI, Keita
GOTOH, Izumi
ASANO, Yukiyasu
YAMADA, Yurie
HARADA, Satoko
IZUCHI, Toru
KITAMOTO, Katsunori
OHSAWA, Yasushi
description An object of the present invention is to provide a compound having a V2 receptor agonistic activity. Provided is a pharmaceutical composition which contains, as an active ingredient, a compound represented by the general formula (I) described below: [wherein R 1 is the formula described below: (wherein A is a lower alkylene group which may be substituted with a lower alkyl group, or the like; R 6 is a hydrogen atom, or the like; R 7 is a hydroxyl group, an aromatic heterocyclic group which may be substituted with a lower alkyl group, a carbamoyl group, or the like) ; R 2 is a hydrogen atom or a lower alkyl group; R 3 is a lower alkyl group which may be substituted with 1 to 3 fluorine atoms, or a halogen atom; R 4 is a five-membered aromatic monocyclic heterocyclic group, a five-membered non-aromatic monocyclic heterocyclic group, or the like, (provided that each of these heterocyclic groups contains at least one nitrogen atom and may be substituted with a lower alkyl group) ; and R 5 is a lower alkyl group, a halogen atom, or the like], or a pharmacologically acceptable salt thereof.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Nyt benzazepinderivat og farmaceutisk anvendelse deraf
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