ASYMMETRISK HYDROGENERING AF 1,1,1-TRIFLUORACETONE
The invention relates to the preparation of enantiomerically pure (S)-1,1,1-trifluoro-2-propanol by asymmetric hydrogenation of 1,1,1-trifluoroacetone which process comprises hydrogenating 1,1,1-trifluoroacetone in the presence of a ruthenium phosphine complex catalyst represented by formula Ru(E)(E...
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| creator | PUENTENER, KURT WALDMEIER, PIUS |
| description | The invention relates to the preparation of enantiomerically pure (S)-1,1,1-trifluoro-2-propanol by asymmetric hydrogenation of 1,1,1-trifluoroacetone which process comprises hydrogenating 1,1,1-trifluoroacetone in the presence of a ruthenium phosphine complex catalyst represented by formula Ru(E)(E')(L)(A) wherein E, E' are both chloro or E is hydrogen and E' is BH4; L is a chiral diphosphine ligand; and A is an optionally chiral diamine wherein hydrogenation occurs in the presence of a weak base, with or without an additive, when E and E' are both chloro or b) in the absence of a base and an additive when E and E' are hydrogen and BH4. |
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L is a chiral diphosphine ligand; and A is an optionally chiral diamine wherein hydrogenation occurs in the presence of a weak base, with or without an additive, when E and E' are both chloro or b) in the absence of a base and an additive when E and E' are hydrogen and BH4.</description><language>dan</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; METALLURGY ; ORGANIC CHEMISTRY</subject><creationdate>2013</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130603&DB=EPODOC&CC=DK&NR=2054363T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,309,781,886,25569,76552</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20130603&DB=EPODOC&CC=DK&NR=2054363T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>PUENTENER, KURT</creatorcontrib><creatorcontrib>WALDMEIER, PIUS</creatorcontrib><title>ASYMMETRISK HYDROGENERING AF 1,1,1-TRIFLUORACETONE</title><description>The invention relates to the preparation of enantiomerically pure (S)-1,1,1-trifluoro-2-propanol by asymmetric hydrogenation of 1,1,1-trifluoroacetone which process comprises hydrogenating 1,1,1-trifluoroacetone in the presence of a ruthenium phosphine complex catalyst represented by formula Ru(E)(E')(L)(A) wherein E, E' are both chloro or E is hydrogen and E' is BH4; L is a chiral diphosphine ligand; and A is an optionally chiral diamine wherein hydrogenation occurs in the presence of a weak base, with or without an additive, when E and E' are both chloro or b) in the absence of a base and an additive when E and E' are hydrogen and BH4.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2013</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZDByDI709XUNCfIM9lbwiHQJ8nd39XMN8vRzV3B0UzDUAUJdoKSbT6h_kKOza4i_nysPA2taYk5xKi-U5mZQdHMNcfbQTS3Ij08tLkhMTs1LLYl38TYyMDUxNjMOCTE2JkYNAHztJxo</recordid><startdate>20130603</startdate><enddate>20130603</enddate><creator>PUENTENER, KURT</creator><creator>WALDMEIER, PIUS</creator><scope>EVB</scope></search><sort><creationdate>20130603</creationdate><title>ASYMMETRISK HYDROGENERING AF 1,1,1-TRIFLUORACETONE</title><author>PUENTENER, KURT ; WALDMEIER, PIUS</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_DK2054363TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>dan</language><creationdate>2013</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><toplevel>online_resources</toplevel><creatorcontrib>PUENTENER, KURT</creatorcontrib><creatorcontrib>WALDMEIER, PIUS</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>PUENTENER, KURT</au><au>WALDMEIER, PIUS</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>ASYMMETRISK HYDROGENERING AF 1,1,1-TRIFLUORACETONE</title><date>2013-06-03</date><risdate>2013</risdate><abstract>The invention relates to the preparation of enantiomerically pure (S)-1,1,1-trifluoro-2-propanol by asymmetric hydrogenation of 1,1,1-trifluoroacetone which process comprises hydrogenating 1,1,1-trifluoroacetone in the presence of a ruthenium phosphine complex catalyst represented by formula Ru(E)(E')(L)(A) wherein E, E' are both chloro or E is hydrogen and E' is BH4; L is a chiral diphosphine ligand; and A is an optionally chiral diamine wherein hydrogenation occurs in the presence of a weak base, with or without an additive, when E and E' are both chloro or b) in the absence of a base and an additive when E and E' are hydrogen and BH4.</abstract><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY METALLURGY ORGANIC CHEMISTRY |
| title | ASYMMETRISK HYDROGENERING AF 1,1,1-TRIFLUORACETONE |
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