18-methyl-19-nor-androst-4-en-17,17-spiroether (18-methyl-19-nor-20-spirox-4-en-3-oner) og farmaceutiske præparater, der indeholder disse

The present invention describes the novel 18-methyl-19-norandrost-4-ene 17,17-spiro ethers of the general formula I in which Z is an oxygen atom, two hydrogen atoms, a group NOR or NNHSO2R, where R is a hydrogen atom or a straight- or branched-chain alkyl group having 1 to 4 or 3 to 4 carbon atoms,...

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Hauptverfasser:	BOHLMANN, ROLF, MUHN, HANS-PETER, GALLUS, NORBERT, PRELLE, KATJA, MENGES, FREDERIK, KUHNKE, JOACHIM, HUEBNER, JAN, BORDEN, STEFFEN
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Schlagworte:	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS STEROIDS
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creator	BOHLMANN, ROLF MUHN, HANS-PETER GALLUS, NORBERT PRELLE, KATJA MENGES, FREDERIK KUHNKE, JOACHIM HUEBNER, JAN BORDEN, STEFFEN
description	The present invention describes the novel 18-methyl-19-norandrost-4-ene 17,17-spiro ethers of the general formula I in which Z is an oxygen atom, two hydrogen atoms, a group NOR or NNHSO2R, where R is a hydrogen atom or a straight- or branched-chain alkyl group having 1 to 4 or 3 to 4 carbon atoms, R4 is a hydrogen atom, a halogen atom or a trifluoromethyl group, and R6 and/or R7 may have α or configuration, and R6 and R7 are independently of one another a hydrogen atom or a straight- or branched-chain alkyl group having 1 to 4 or 3 to 4 carbon atoms or a straight- or branched-chain alkenyl group having 2 to 4 or 3 to 4 carbon atoms or a saturated cycloalkyl group having 3 to 5 carbon atoms or together are a methylene group or a double bond. The novel compounds have progestational and antimineralocorticoid activity.
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subjects	CHEMISTRY HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS STEROIDS
title	18-methyl-19-nor-androst-4-en-17,17-spiroether (18-methyl-19-nor-20-spirox-4-en-3-oner) og farmaceutiske præparater, der indeholder disse
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