New cyclic amine cpds

Cyclic amine cpds. of formula (I) and their salts are new. J is (a) a gp., opt. substd., of: phenyl, pyridyl, pyrazyl, cyclohexyl, quino(xa)lyl or furyl; (b) a monovalent or divalent gp., where the phenyl may have substit(s), of: indan(ol)yl, (iii) inden(on)yl, indan(edio)hyl, tetralonyl, benzosuber...

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Hauptverfasser: SASAKI, JUN, OGURA, HIROO, HIGURASHI, KUNIZOU, ARAKI, SHIN, TSUCHIYA, YUTAKA, KOZASA, MICHIKO, SUGIMOTO, HACHIRO, KARIBE, NORIE, IIMURA, YOICHI, KOZASA, TAKASHI, YAMATSU, KIYOMI, YAMANISHI, YOSHIHARU, KUBOTA, ATSUHIKO
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creator SASAKI, JUN
OGURA, HIROO
HIGURASHI, KUNIZOU
ARAKI, SHIN
TSUCHIYA, YUTAKA
KOZASA, MICHIKO
SUGIMOTO, HACHIRO
KARIBE, NORIE
IIMURA, YOICHI
KOZASA, TAKASHI
YAMATSU, KIYOMI
YAMANISHI, YOSHIHARU
KUBOTA, ATSUHIKO
description Cyclic amine cpds. of formula (I) and their salts are new. J is (a) a gp., opt. substd., of: phenyl, pyridyl, pyrazyl, cyclohexyl, quino(xa)lyl or furyl; (b) a monovalent or divalent gp., where the phenyl may have substit(s), of: indan(ol)yl, (iii) inden(on)yl, indan(edio)hyl, tetralonyl, benzosuberonyl, or C6H5-CO-CH(CH3)-; (c) a monovalent gp. derived from a cyclic amide cpd. (d) lower alkyl; or (e) R21-CH=CH- (R21 = H or (lower alkoxycarbonyl). B = (CHR22)r, CO(CHR22)r, NR4-(HCR22)r, CO-NR5-(CHR22)r, CH=CH-(CHR22)r, OCOO-(CHR22)r, OOC-NH-(CHR22)r, NH-CO-(CHR32)4, CH2CONH-(CHR22)r, (CH2)2CONH-(CHR22)r, CH(OH)-(CHR22)r, CH(OH)-(CHR22)r, = (CH-CH=CH)b, =CH-(CH2)c, =(CH-CH)d, COCH=CH-CH2, COCH2-CH(CH(OH)CH2, CH(CH3)CONHCH2, CH=CHCONH(CH2)2, NH, O, S, dialkylaminoalkylcarbonyl or lower alkoxycarbonyl; R4 = H, acyl, lower alkyl(sulphonyl), (substd.)phenyl, or (substd.)benzyl; R5 = H, lower alkyl or phenyl, r = 0-10; R22 = H or Me such that one alkylene may have no CH3 or one or more CH3; b = 1-3; c = 0-9; d = 0-5; T = N or C (i) Q = N, C or (i) q = 1-3; K = H, (substd.) phenyl, arylalkyl in which the phenyl may be substd. cinnamyl, lower alkyl, pyridylmethyl, cyclo(alkyl)alkyl, adamantanemethyl, furylmethyl, lower alkoxycarbonyl or acyl; and dotted lines is a single-or double-bond. 1-benzyl-4-((5,6-dimethoxy -1-indanon)- 2-ylidenyl)methyl) piperidine hydrochlorideis and example.
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J is (a) a gp., opt. substd., of: phenyl, pyridyl, pyrazyl, cyclohexyl, quino(xa)lyl or furyl; (b) a monovalent or divalent gp., where the phenyl may have substit(s), of: indan(ol)yl, (iii) inden(on)yl, indan(edio)hyl, tetralonyl, benzosuberonyl, or C6H5-CO-CH(CH3)-; (c) a monovalent gp. derived from a cyclic amide cpd. (d) lower alkyl; or (e) R21-CH=CH- (R21 = H or (lower alkoxycarbonyl). B = (CHR22)r, CO(CHR22)r, NR4-(HCR22)r, CO-NR5-(CHR22)r, CH=CH-(CHR22)r, OCOO-(CHR22)r, OOC-NH-(CHR22)r, NH-CO-(CHR32)4, CH2CONH-(CHR22)r, (CH2)2CONH-(CHR22)r, CH(OH)-(CHR22)r, CH(OH)-(CHR22)r, = (CH-CH=CH)b, =CH-(CH2)c, =(CH-CH)d, COCH=CH-CH2, COCH2-CH(CH(OH)CH2, CH(CH3)CONHCH2, CH=CHCONH(CH2)2, NH, O, S, dialkylaminoalkylcarbonyl or lower alkoxycarbonyl; R4 = H, acyl, lower alkyl(sulphonyl), (substd.)phenyl, or (substd.)benzyl; R5 = H, lower alkyl or phenyl, r = 0-10; R22 = H or Me such that one alkylene may have no CH3 or one or more CH3; b = 1-3; c = 0-9; d = 0-5; T = N or C (i) Q = N, C or (i) q = 1-3; K = H, (substd.) phenyl, arylalkyl in which the phenyl may be substd. cinnamyl, lower alkyl, pyridylmethyl, cyclo(alkyl)alkyl, adamantanemethyl, furylmethyl, lower alkoxycarbonyl or acyl; and dotted lines is a single-or double-bond. 1-benzyl-4-((5,6-dimethoxy -1-indanon)- 2-ylidenyl)methyl) piperidine hydrochlorideis and example.</description><edition>7</edition><language>dan ; eng</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2004</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20040719&amp;DB=EPODOC&amp;CC=DK&amp;NR=175246B1$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25562,76317</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&amp;date=20040719&amp;DB=EPODOC&amp;CC=DK&amp;NR=175246B1$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SASAKI, JUN</creatorcontrib><creatorcontrib>OGURA, HIROO</creatorcontrib><creatorcontrib>HIGURASHI, KUNIZOU</creatorcontrib><creatorcontrib>ARAKI, SHIN</creatorcontrib><creatorcontrib>TSUCHIYA, YUTAKA</creatorcontrib><creatorcontrib>KOZASA, MICHIKO</creatorcontrib><creatorcontrib>SUGIMOTO, HACHIRO</creatorcontrib><creatorcontrib>KARIBE, NORIE</creatorcontrib><creatorcontrib>IIMURA, YOICHI</creatorcontrib><creatorcontrib>KOZASA, TAKASHI</creatorcontrib><creatorcontrib>YAMATSU, KIYOMI</creatorcontrib><creatorcontrib>YAMANISHI, YOSHIHARU</creatorcontrib><creatorcontrib>KUBOTA, ATSUHIKO</creatorcontrib><title>New cyclic amine cpds</title><description>Cyclic amine cpds. of formula (I) and their salts are new. J is (a) a gp., opt. substd., of: phenyl, pyridyl, pyrazyl, cyclohexyl, quino(xa)lyl or furyl; (b) a monovalent or divalent gp., where the phenyl may have substit(s), of: indan(ol)yl, (iii) inden(on)yl, indan(edio)hyl, tetralonyl, benzosuberonyl, or C6H5-CO-CH(CH3)-; (c) a monovalent gp. derived from a cyclic amide cpd. (d) lower alkyl; or (e) R21-CH=CH- (R21 = H or (lower alkoxycarbonyl). B = (CHR22)r, CO(CHR22)r, NR4-(HCR22)r, CO-NR5-(CHR22)r, CH=CH-(CHR22)r, OCOO-(CHR22)r, OOC-NH-(CHR22)r, NH-CO-(CHR32)4, CH2CONH-(CHR22)r, (CH2)2CONH-(CHR22)r, CH(OH)-(CHR22)r, CH(OH)-(CHR22)r, = (CH-CH=CH)b, =CH-(CH2)c, =(CH-CH)d, COCH=CH-CH2, COCH2-CH(CH(OH)CH2, CH(CH3)CONHCH2, CH=CHCONH(CH2)2, NH, O, S, dialkylaminoalkylcarbonyl or lower alkoxycarbonyl; R4 = H, acyl, lower alkyl(sulphonyl), (substd.)phenyl, or (substd.)benzyl; R5 = H, lower alkyl or phenyl, r = 0-10; R22 = H or Me such that one alkylene may have no CH3 or one or more CH3; b = 1-3; c = 0-9; d = 0-5; T = N or C (i) Q = N, C or (i) q = 1-3; K = H, (substd.) phenyl, arylalkyl in which the phenyl may be substd. cinnamyl, lower alkyl, pyridylmethyl, cyclo(alkyl)alkyl, adamantanemethyl, furylmethyl, lower alkoxycarbonyl or acyl; and dotted lines is a single-or double-bond. 1-benzyl-4-((5,6-dimethoxy -1-indanon)- 2-ylidenyl)methyl) piperidine hydrochlorideis and example.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2004</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZBD1Sy1XSK5MzslMVkjMzcxLVUguSCnmYWBNS8wpTuWF0twMCm6uIc4euqkF-fGpxQWJyal5qSXxLt6G5qZGJmZOTobGRCgBAA6rIGU</recordid><startdate>20040719</startdate><enddate>20040719</enddate><creator>SASAKI, JUN</creator><creator>OGURA, HIROO</creator><creator>HIGURASHI, KUNIZOU</creator><creator>ARAKI, SHIN</creator><creator>TSUCHIYA, YUTAKA</creator><creator>KOZASA, MICHIKO</creator><creator>SUGIMOTO, HACHIRO</creator><creator>KARIBE, NORIE</creator><creator>IIMURA, YOICHI</creator><creator>KOZASA, TAKASHI</creator><creator>YAMATSU, KIYOMI</creator><creator>YAMANISHI, YOSHIHARU</creator><creator>KUBOTA, ATSUHIKO</creator><scope>EVB</scope></search><sort><creationdate>20040719</creationdate><title>New cyclic amine cpds</title><author>SASAKI, JUN ; OGURA, HIROO ; HIGURASHI, KUNIZOU ; ARAKI, SHIN ; TSUCHIYA, YUTAKA ; KOZASA, MICHIKO ; SUGIMOTO, HACHIRO ; KARIBE, NORIE ; IIMURA, YOICHI ; KOZASA, TAKASHI ; YAMATSU, KIYOMI ; YAMANISHI, YOSHIHARU ; KUBOTA, ATSUHIKO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_DK175246BB13</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>dan ; eng</language><creationdate>2004</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>SASAKI, JUN</creatorcontrib><creatorcontrib>OGURA, HIROO</creatorcontrib><creatorcontrib>HIGURASHI, KUNIZOU</creatorcontrib><creatorcontrib>ARAKI, SHIN</creatorcontrib><creatorcontrib>TSUCHIYA, YUTAKA</creatorcontrib><creatorcontrib>KOZASA, MICHIKO</creatorcontrib><creatorcontrib>SUGIMOTO, HACHIRO</creatorcontrib><creatorcontrib>KARIBE, NORIE</creatorcontrib><creatorcontrib>IIMURA, YOICHI</creatorcontrib><creatorcontrib>KOZASA, TAKASHI</creatorcontrib><creatorcontrib>YAMATSU, KIYOMI</creatorcontrib><creatorcontrib>YAMANISHI, YOSHIHARU</creatorcontrib><creatorcontrib>KUBOTA, ATSUHIKO</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SASAKI, JUN</au><au>OGURA, HIROO</au><au>HIGURASHI, KUNIZOU</au><au>ARAKI, SHIN</au><au>TSUCHIYA, YUTAKA</au><au>KOZASA, MICHIKO</au><au>SUGIMOTO, HACHIRO</au><au>KARIBE, NORIE</au><au>IIMURA, YOICHI</au><au>KOZASA, TAKASHI</au><au>YAMATSU, KIYOMI</au><au>YAMANISHI, YOSHIHARU</au><au>KUBOTA, ATSUHIKO</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>New cyclic amine cpds</title><date>2004-07-19</date><risdate>2004</risdate><abstract>Cyclic amine cpds. of formula (I) and their salts are new. J is (a) a gp., opt. substd., of: phenyl, pyridyl, pyrazyl, cyclohexyl, quino(xa)lyl or furyl; (b) a monovalent or divalent gp., where the phenyl may have substit(s), of: indan(ol)yl, (iii) inden(on)yl, indan(edio)hyl, tetralonyl, benzosuberonyl, or C6H5-CO-CH(CH3)-; (c) a monovalent gp. derived from a cyclic amide cpd. (d) lower alkyl; or (e) R21-CH=CH- (R21 = H or (lower alkoxycarbonyl). B = (CHR22)r, CO(CHR22)r, NR4-(HCR22)r, CO-NR5-(CHR22)r, CH=CH-(CHR22)r, OCOO-(CHR22)r, OOC-NH-(CHR22)r, NH-CO-(CHR32)4, CH2CONH-(CHR22)r, (CH2)2CONH-(CHR22)r, CH(OH)-(CHR22)r, CH(OH)-(CHR22)r, = (CH-CH=CH)b, =CH-(CH2)c, =(CH-CH)d, COCH=CH-CH2, COCH2-CH(CH(OH)CH2, CH(CH3)CONHCH2, CH=CHCONH(CH2)2, NH, O, S, dialkylaminoalkylcarbonyl or lower alkoxycarbonyl; R4 = H, acyl, lower alkyl(sulphonyl), (substd.)phenyl, or (substd.)benzyl; R5 = H, lower alkyl or phenyl, r = 0-10; R22 = H or Me such that one alkylene may have no CH3 or one or more CH3; b = 1-3; c = 0-9; d = 0-5; T = N or C (i) Q = N, C or (i) q = 1-3; K = H, (substd.) phenyl, arylalkyl in which the phenyl may be substd. cinnamyl, lower alkyl, pyridylmethyl, cyclo(alkyl)alkyl, adamantanemethyl, furylmethyl, lower alkoxycarbonyl or acyl; and dotted lines is a single-or double-bond. 1-benzyl-4-((5,6-dimethoxy -1-indanon)- 2-ylidenyl)methyl) piperidine hydrochlorideis and example.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record>
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title New cyclic amine cpds
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