C1 symmetriske biphosphinlegander og deres anvendelse i asymmetrisk syntese af pregabilin

Materials and Methods for preparing (S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid and structurally related compounds via enantioselective hydrogenation of prochiral olefins are disclosed. The methods employ novel chiral catalysts, which include C1-symmetric bisphosphine ligands bound to transition...

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Hauptverfasser: PFLUM, DEREK ANDREW, BAO, JIAN, HOGE, GARRETT, WU, HE-PING, MARLATT, MARK EUGENE, GREENE, DEREK JOSEPH, BEYLIN, VLADIMIR GENUKH, KISSEL, WILLIAM SCOTT
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creator PFLUM, DEREK ANDREW
BAO, JIAN
HOGE, GARRETT
WU, HE-PING
MARLATT, MARK EUGENE
GREENE, DEREK JOSEPH
BEYLIN, VLADIMIR GENUKH
KISSEL, WILLIAM SCOTT
description Materials and Methods for preparing (S)-(+)-3-(aminomethyl)-5-methyl-hexanoic acid and structurally related compounds via enantioselective hydrogenation of prochiral olefins are disclosed. The methods employ novel chiral catalysts, which include C1-symmetric bisphosphine ligands bound to transition metals.
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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM
APPARATUS THEREFOR
CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOIDCHEMISTRY
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
PERFORMING OPERATIONS
PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
THEIR RELEVANT APPARATUS
TRANSPORTING
title C1 symmetriske biphosphinlegander og deres anvendelse i asymmetrisk syntese af pregabilin
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