Fremgangsmåde til screening af glycoform-specifikke antistoffer

Fremgangsmåde til screening af glycoform-specifikke antistoffer

The present invention relates to the use of the assessment of the binding between-antibodies elicited against a first glycoprotein, and-at least one glycoform of a second glycoprotein, said second glycoprotein being itself a glycoform of the first protein, wherein said glycoform of the second glycop...

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Hauptverfasser: RONIN, CATHERINE, DONADIO, SANDRINE
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CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
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creator RONIN, CATHERINE
DONADIO, SANDRINE
description The present invention relates to the use of the assessment of the binding between-antibodies elicited against a first glycoprotein, and-at least one glycoform of a second glycoprotein, said second glycoprotein being itself a glycoform of the first protein, wherein said glycoform of the second glycoprotein is selected from a group of glycoforms of the second glycoprotein, each glycoform of said group corresponding to a determined glycosylation state defined by a determined sialylation state, and/or a determined branching state, and/or a determined fucosylation state, provided that said glycosylation state is not uniquely defined by a substantially unsialylated state, for the screening of glycoform specific antibodies directed against a given glycoform of the second glycoprotein.
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subjects CHEMISTRY
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIRCHEMICAL OR PHYSICAL PROPERTIES
MEASURING
METALLURGY
ORGANIC CHEMISTRY
PEPTIDES
PHYSICS
TESTING
title Fremgangsmåde til screening af glycoform-specifikke antistoffer
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