ANALOGIFREMGANGSMAADE TIL FREMSTILLING AF 5-(3,4-DISUBST. PHENYL)-OXAZOLIDINONER ELLER THIAZOLIDINONER ELLER DE TILSVARENDE THIONER
Novel 5-(subst. phenyl)-oxazolidinones and their sulphur analogs of the general formula I in which the substituents are defined in Claim 1, are obtained by reacting 2-amino-1(3,4-disubst. phenyl)-ethanols with a carbonic acid derivative or a thiocarbonic acid derivative in an inert solvent while hea...
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| creator | GERT PASCHELKE HELMUT WACHTEL RALPH SCHMIECHEN DIETER PALENSCHAT ANDREAS HUTH WOLFGANG KEHR HERBERT HANS SCHNEIDER |
| description | Novel 5-(subst. phenyl)-oxazolidinones and their sulphur analogs of the general formula I in which the substituents are defined in Claim 1, are obtained by reacting 2-amino-1(3,4-disubst. phenyl)-ethanols with a carbonic acid derivative or a thiocarbonic acid derivative in an inert solvent while heating in the presence of a basic catalyst. The novel compounds of the general formula I possess valuable pharmacological properties. They exhibit antidopaminergic, antinociceptive and anticonvulsive effects and have a depressant action on the central nervous system and thus have a certain similarity to neuroleptic agents such as chlorpromazine or haloperidol. In addition, the novel compounds possess strong phosphodiesterase-inhibiting properties and thus affect the metabolism of cyclic nucleotides. The compounds are also suitable for treating hyperproliferative diseases and diseases associated with uncontrolled cell growth. |
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PHENYL)-OXAZOLIDINONER ELLER THIAZOLIDINONER ELLER DE TILSVARENDE THIONER</title><source>esp@cenet</source><creator>GERT PASCHELKE ; HELMUT WACHTEL ; RALPH SCHMIECHEN ; DIETER PALENSCHAT ; ANDREAS HUTH ; WOLFGANG KEHR ; HERBERT HANS SCHNEIDER</creator><creatorcontrib>GERT PASCHELKE ; HELMUT WACHTEL ; RALPH SCHMIECHEN ; DIETER PALENSCHAT ; ANDREAS HUTH ; WOLFGANG KEHR ; HERBERT HANS SCHNEIDER</creatorcontrib><description>Novel 5-(subst. phenyl)-oxazolidinones and their sulphur analogs of the general formula I in which the substituents are defined in Claim 1, are obtained by reacting 2-amino-1(3,4-disubst. phenyl)-ethanols with a carbonic acid derivative or a thiocarbonic acid derivative in an inert solvent while heating in the presence of a basic catalyst. The novel compounds of the general formula I possess valuable pharmacological properties. They exhibit antidopaminergic, antinociceptive and anticonvulsive effects and have a depressant action on the central nervous system and thus have a certain similarity to neuroleptic agents such as chlorpromazine or haloperidol. In addition, the novel compounds possess strong phosphodiesterase-inhibiting properties and thus affect the metabolism of cyclic nucleotides. 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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | ANALOGIFREMGANGSMAADE TIL FREMSTILLING AF 5-(3,4-DISUBST. PHENYL)-OXAZOLIDINONER ELLER THIAZOLIDINONER ELLER DE TILSVARENDE THIONER |
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