FREMGANGSMAADE TIL FREMSTILLING AF ISOSORBID-2-NITRAT

A process for the preparation of isosorbide-2-nitrate of the formula comprising contacting isosorbide with a carboxylic acid anhydride in the presence of a metal salt; esterifying the resultant isosorbide-5-acylate with nitric acid; and converting the resultant isosorbide-5-acylate-2-nitrate to isos...

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Zusammenfassung:A process for the preparation of isosorbide-2-nitrate of the formula comprising contacting isosorbide with a carboxylic acid anhydride in the presence of a metal salt; esterifying the resultant isosorbide-5-acylate with nitric acid; and converting the resultant isosorbide-5-acylate-2-nitrate to isosorbide-2-nitrate by treatment with an alkyl alcohol in the presence of an alkali metal alcoholate.