ANALOGIFREMGANGSMAADE TIL FREMSTILLING AF CEPHALOSPORINFORBINDELSER ELLER UGIFTIGE SALTE, BIOLOGISK ACCEPTABLE ESTERE, 1-OXYDER ELLER SOLVATER DERAF
Preparation of the syn isomer or of a mixture of syn isomer and anti isomer, where the content of the syn isomer is at least 90%, of 7-acylaminoceph-3-em-4-carboxylic acids with antibiotic activity and the formula I in which B is > S or > S->O; R is furyl, thienyl or phenyl; and R is C1-C4-...
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| creator | MARTIN CHRISTOPHER COOK GORDON IAN GREGORY JANICE BRADSHAW |
| description | Preparation of the syn isomer or of a mixture of syn isomer and anti isomer, where the content of the syn isomer is at least 90%, of 7-acylaminoceph-3-em-4-carboxylic acids with antibiotic activity and the formula I in which B is > S or > S->O; R is furyl, thienyl or phenyl; and R is C1-C4-alkyl, C3-C7-cycloalkyl or phenyl, and of their non-toxic salts, including their solvates, and esters by acylation of the corresponding 7-amino compound, where appropriate with intermediate protection of the 4-carboxyl group and/or of the 3-carbamoyloxymethyl group, and subsequent isomerisation of a ceph-2-em compound which is obtained where appropriate to the ceph-3-em compound. The compounds are distinguished by a broad spectrum of action on pathogenic microorganisms, the ability to resist beta -lactamases and good stability in vivo. |
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The compounds are distinguished by a broad spectrum of action on pathogenic microorganisms, the ability to resist beta -lactamases and good stability in vivo.</abstract><edition>3</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS VETERINARY INSTRUMENTS, IMPLEMENTS, TOOLS, OR METHODS |
| title | ANALOGIFREMGANGSMAADE TIL FREMSTILLING AF CEPHALOSPORINFORBINDELSER ELLER UGIFTIGE SALTE, BIOLOGISK ACCEPTABLE ESTERE, 1-OXYDER ELLER SOLVATER DERAF |
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