Quninazolin og pyridopyrmidin-derivativer

Compounds of formula (I) and salts or solvates thereof are disclosed wherein Y is CR and V is N; or Y is CR and V is CR ; R represents CH3SO2CH2CH2NHCH2-Ar-, wherein Ar is furan or thiazole, each of which may optionally be substituted by one or two halo, C1-4 alkyl or C1-4 alkoxy groups; R is hydrog...

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Hauptverfasser: LACKEY, KAREN E, COCKERILL, GEORGE STUART, GUNTRIP, STEPHEN B, SMITH, KATHRYN J, CARTER, MALCOLM CLIVE
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creator LACKEY, KAREN E
COCKERILL, GEORGE STUART
GUNTRIP, STEPHEN B
SMITH, KATHRYN J
CARTER, MALCOLM CLIVE
description Compounds of formula (I) and salts or solvates thereof are disclosed wherein Y is CR and V is N; or Y is CR and V is CR ; R represents CH3SO2CH2CH2NHCH2-Ar-, wherein Ar is furan or thiazole, each of which may optionally be substituted by one or two halo, C1-4 alkyl or C1-4 alkoxy groups; R is hydrogen C1-4 alkoxy or halo; R is benzyl, halo-, dihalo- or trihalobenzyl, benzoyl, pyridylmethyl, pyridylmethoxy, phenoxy, benzyloxy, halo-, dihalo- or trihalobenzyloxy or benzenesulphonyl; R is halo or C1-4 alkoxy or is not present; and wherein either (a) R represents 3-fluorobenzyloxy; and/or (b) R is halo and is substituted in the 3-position of the phenyl ring; and wherein halo represents fluoro, chloro or bromo. Processes for the preparation of the compounds, pharmaceutical formulations of the compounds, the use of the compounds in therapy, and methods of treatment of inter alia cancer and malignant tumours by administration of the compounds is also disclosed.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Quninazolin og pyridopyrmidin-derivativer
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