PROSTAGLANDINDERIVATER OG FREMGANGSMADE TIL FREMSTILLING DERAF
Optically active and racemic prostaglandin derivatives of the formula wherein R1 is -OR5; -NHSO2CH3; or -O-CH2-U-V; R5 is hydrogen, alkyl, aryl, or a heterocyclic group; U is a direct bond, carbonyl or carbonyloxy; and V is phenyl substituted by 1-3 phenyl, alkoxy of 1-2 carbon atoms, or halogen, pr...
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| creator | SKUBALLA W RADYCHEL B SCHILLINGER E VORBRYGGEN H LOGE O ELGER W |
| description | Optically active and racemic prostaglandin derivatives of the formula wherein R1 is -OR5; -NHSO2CH3; or -O-CH2-U-V; R5 is hydrogen, alkyl, aryl, or a heterocyclic group; U is a direct bond, carbonyl or carbonyloxy; and V is phenyl substituted by 1-3 phenyl, alkoxy of 1-2 carbon atoms, or halogen, preferably bromine; R2 is hydrogen or alkyl of 1-5 carbon atoms; R3 is alkyl, substituted or unsubstituted cycloalkyl, straight-chain or branched alkyl of 1-5 carbon atoms substituted by aryl or substituted aryl, when R1 is as above; or R3 is aryl or substituted aryl group when R1 is -OR5', -NHSO2CH3, or -O-CH2-U-V and R5' is aryl or a heterocyclic group and U and V are as above; R4 is hydrogen or an ether or acyl residue; A is -CH2-CH2- or cis-CH=CH-; B is -CH2-CH2- or trans-CH=CH-; D is a direct bond, oxygen, or sulfur; Z is carbonyl or >CH OR4 wherein OR4 is in the alpha - or beta -position; and X Y is when Z is >CH OR4-, or or -CH=CH- when Z is carbonyl; AND, WHEN R1 is hydroxy, the physiologically compatible salts thereof with bases, have more prolonged activity than naturally-occurring prostaglandins. |
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| fullrecord | <record><control><sourceid>epo_EVB</sourceid><recordid>TN_cdi_epo_espacenet_DK142976A</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>DK142976A</sourcerecordid><originalsourceid>FETCH-epo_espacenet_DK142976A3</originalsourceid><addsrcrecordid>eNrjZLALCPIPDnF093H0c_H0c3EN8gxzDHENUvB3V3ALcvV1d_RzD_Z1dHFVCPH0AYsEAxk-nn7uCkC1jm48DKxpiTnFqbxQmptBzs01xNlDN7UgPz61uCAxOTUvtSTexdvQxMjS3MzRmKACAJDBKTM</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>patent</recordtype></control><display><type>patent</type><title>PROSTAGLANDINDERIVATER OG FREMGANGSMADE TIL FREMSTILLING DERAF</title><source>esp@cenet</source><creator>SKUBALLA W ; RADYCHEL B ; SCHILLINGER E ; VORBRYGGEN H ; LOGE O ; ELGER W</creator><creatorcontrib>SKUBALLA W ; RADYCHEL B ; SCHILLINGER E ; VORBRYGGEN H ; LOGE O ; ELGER W</creatorcontrib><description>Optically active and racemic prostaglandin derivatives of the formula wherein R1 is -OR5; -NHSO2CH3; or -O-CH2-U-V; R5 is hydrogen, alkyl, aryl, or a heterocyclic group; U is a direct bond, carbonyl or carbonyloxy; and V is phenyl substituted by 1-3 phenyl, alkoxy of 1-2 carbon atoms, or halogen, preferably bromine; R2 is hydrogen or alkyl of 1-5 carbon atoms; R3 is alkyl, substituted or unsubstituted cycloalkyl, straight-chain or branched alkyl of 1-5 carbon atoms substituted by aryl or substituted aryl, when R1 is as above; or R3 is aryl or substituted aryl group when R1 is -OR5', -NHSO2CH3, or -O-CH2-U-V and R5' is aryl or a heterocyclic group and U and V are as above; R4 is hydrogen or an ether or acyl residue; A is -CH2-CH2- or cis-CH=CH-; B is -CH2-CH2- or trans-CH=CH-; D is a direct bond, oxygen, or sulfur; Z is carbonyl or >CH OR4 wherein OR4 is in the alpha - or beta -position; and X Y is when Z is >CH OR4-, or or -CH=CH- when Z is carbonyl; AND, WHEN R1 is hydroxy, the physiologically compatible salts thereof with bases, have more prolonged activity than naturally-occurring prostaglandins.</description><edition>2</edition><language>dan</language><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><creationdate>1976</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19761019&DB=EPODOC&CC=DK&NR=142976A$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25563,76418</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=19761019&DB=EPODOC&CC=DK&NR=142976A$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>SKUBALLA W</creatorcontrib><creatorcontrib>RADYCHEL B</creatorcontrib><creatorcontrib>SCHILLINGER E</creatorcontrib><creatorcontrib>VORBRYGGEN H</creatorcontrib><creatorcontrib>LOGE O</creatorcontrib><creatorcontrib>ELGER W</creatorcontrib><title>PROSTAGLANDINDERIVATER OG FREMGANGSMADE TIL FREMSTILLING DERAF</title><description>Optically active and racemic prostaglandin derivatives of the formula wherein R1 is -OR5; -NHSO2CH3; or -O-CH2-U-V; R5 is hydrogen, alkyl, aryl, or a heterocyclic group; U is a direct bond, carbonyl or carbonyloxy; and V is phenyl substituted by 1-3 phenyl, alkoxy of 1-2 carbon atoms, or halogen, preferably bromine; R2 is hydrogen or alkyl of 1-5 carbon atoms; R3 is alkyl, substituted or unsubstituted cycloalkyl, straight-chain or branched alkyl of 1-5 carbon atoms substituted by aryl or substituted aryl, when R1 is as above; or R3 is aryl or substituted aryl group when R1 is -OR5', -NHSO2CH3, or -O-CH2-U-V and R5' is aryl or a heterocyclic group and U and V are as above; R4 is hydrogen or an ether or acyl residue; A is -CH2-CH2- or cis-CH=CH-; B is -CH2-CH2- or trans-CH=CH-; D is a direct bond, oxygen, or sulfur; Z is carbonyl or >CH OR4 wherein OR4 is in the alpha - or beta -position; and X Y is when Z is >CH OR4-, or or -CH=CH- when Z is carbonyl; AND, WHEN R1 is hydroxy, the physiologically compatible salts thereof with bases, have more prolonged activity than naturally-occurring prostaglandins.</description><subject>ACYCLIC OR CARBOCYCLIC COMPOUNDS</subject><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>1976</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLALCPIPDnF093H0c_H0c3EN8gxzDHENUvB3V3ALcvV1d_RzD_Z1dHFVCPH0AYsEAxk-nn7uCkC1jm48DKxpiTnFqbxQmptBzs01xNlDN7UgPz61uCAxOTUvtSTexdvQxMjS3MzRmKACAJDBKTM</recordid><startdate>19761019</startdate><enddate>19761019</enddate><creator>SKUBALLA W</creator><creator>RADYCHEL B</creator><creator>SCHILLINGER E</creator><creator>VORBRYGGEN H</creator><creator>LOGE O</creator><creator>ELGER W</creator><scope>EVB</scope></search><sort><creationdate>19761019</creationdate><title>PROSTAGLANDINDERIVATER OG FREMGANGSMADE TIL FREMSTILLING DERAF</title><author>SKUBALLA W ; RADYCHEL B ; SCHILLINGER E ; VORBRYGGEN H ; LOGE O ; ELGER W</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_DK142976A3</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>dan</language><creationdate>1976</creationdate><topic>ACYCLIC OR CARBOCYCLIC COMPOUNDS</topic><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><toplevel>online_resources</toplevel><creatorcontrib>SKUBALLA W</creatorcontrib><creatorcontrib>RADYCHEL B</creatorcontrib><creatorcontrib>SCHILLINGER E</creatorcontrib><creatorcontrib>VORBRYGGEN H</creatorcontrib><creatorcontrib>LOGE O</creatorcontrib><creatorcontrib>ELGER W</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>SKUBALLA W</au><au>RADYCHEL B</au><au>SCHILLINGER E</au><au>VORBRYGGEN H</au><au>LOGE O</au><au>ELGER W</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>PROSTAGLANDINDERIVATER OG FREMGANGSMADE TIL FREMSTILLING DERAF</title><date>1976-10-19</date><risdate>1976</risdate><abstract>Optically active and racemic prostaglandin derivatives of the formula wherein R1 is -OR5; -NHSO2CH3; or -O-CH2-U-V; R5 is hydrogen, alkyl, aryl, or a heterocyclic group; U is a direct bond, carbonyl or carbonyloxy; and V is phenyl substituted by 1-3 phenyl, alkoxy of 1-2 carbon atoms, or halogen, preferably bromine; R2 is hydrogen or alkyl of 1-5 carbon atoms; R3 is alkyl, substituted or unsubstituted cycloalkyl, straight-chain or branched alkyl of 1-5 carbon atoms substituted by aryl or substituted aryl, when R1 is as above; or R3 is aryl or substituted aryl group when R1 is -OR5', -NHSO2CH3, or -O-CH2-U-V and R5' is aryl or a heterocyclic group and U and V are as above; R4 is hydrogen or an ether or acyl residue; A is -CH2-CH2- or cis-CH=CH-; B is -CH2-CH2- or trans-CH=CH-; D is a direct bond, oxygen, or sulfur; Z is carbonyl or >CH OR4 wherein OR4 is in the alpha - or beta -position; and X Y is when Z is >CH OR4-, or or -CH=CH- when Z is carbonyl; AND, WHEN R1 is hydroxy, the physiologically compatible salts thereof with bases, have more prolonged activity than naturally-occurring prostaglandins.</abstract><edition>2</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC OR CARBOCYCLIC COMPOUNDS CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES |
| title | PROSTAGLANDINDERIVATER OG FREMGANGSMADE TIL FREMSTILLING DERAF |
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