Oxindoler som CDK-1-inhibitorer og deres anvendelse i terapi
The present invention relates to a compound of formula (I): wherein R5 is selected from the group consisting of 3-pyridyl, 5-pyrimidinyl, -CONH-(C1-C4 alkyl), -NHCO-(C1-C4 alkyl), halogen, -SO2NH2, -NO2, -CF3 or thien-2-ylcarbonyl and -CO2R where R can be hydrogen or C1-C4 alkyl; and Ar is selected...
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| creator | MARATRAT, MICHEL GRONDARD, LUCILE LAVAYRE, JACQUES MAILLIET, PATRICK THOMPSON, FABIENNE RIOU, JEAN-FRANCOIS PETITGENET, ODILE |
| description | The present invention relates to a compound of formula (I): wherein R5 is selected from the group consisting of 3-pyridyl, 5-pyrimidinyl, -CONH-(C1-C4 alkyl), -NHCO-(C1-C4 alkyl), halogen, -SO2NH2, -NO2, -CF3 or thien-2-ylcarbonyl and -CO2R where R can be hydrogen or C1-C4 alkyl; and Ar is selected from the group consisting of 5-imidazolyl, 2-pyrrolyl optionally substituted by a C1-C4 alkyl radical, 2-furyl or 2-thiazolyl, in the E or Z geometrical isomeric form or a mixture of the two geometrical isomeric forms. The invention is also directed to a method of treating primary and secondary tumours in a patient in need thereof comprising administering to the patient a therapeutically effective amount of a compound of formula I. The invention is also directed to a method of using a compound of formula I to treat cancer, inhibit the proliferation of a cell and induce cell apoptosis, comprising contacting a cell with an effective amount of the compound of formula I., The invention is also directed to a method of preparing the compound of formula I. |
| format | Patent |
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The invention is also directed to a method of treating primary and secondary tumours in a patient in need thereof comprising administering to the patient a therapeutically effective amount of a compound of formula I. The invention is also directed to a method of using a compound of formula I to treat cancer, inhibit the proliferation of a cell and induce cell apoptosis, comprising contacting a cell with an effective amount of the compound of formula I., The invention is also directed to a method of preparing the compound of formula I.</description><edition>7</edition><language>dan</language><subject>CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><creationdate>2005</creationdate><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20051219&DB=EPODOC&CC=DK&NR=1366038T3$$EHTML$$P50$$Gepo$$Hfree_for_read</linktohtml><link.rule.ids>230,308,780,885,25564,76547</link.rule.ids><linktorsrc>$$Uhttps://worldwide.espacenet.com/publicationDetails/biblio?FT=D&date=20051219&DB=EPODOC&CC=DK&NR=1366038T3$$EView_record_in_European_Patent_Office$$FView_record_in_$$GEuropean_Patent_Office$$Hfree_for_read</linktorsrc></links><search><creatorcontrib>MARATRAT, MICHEL</creatorcontrib><creatorcontrib>GRONDARD, LUCILE</creatorcontrib><creatorcontrib>LAVAYRE, JACQUES</creatorcontrib><creatorcontrib>MAILLIET, PATRICK</creatorcontrib><creatorcontrib>THOMPSON, FABIENNE</creatorcontrib><creatorcontrib>RIOU, JEAN-FRANCOIS</creatorcontrib><creatorcontrib>PETITGENET, ODILE</creatorcontrib><title>Oxindoler som CDK-1-inhibitorer og deres anvendelse i terapi</title><description>The present invention relates to a compound of formula (I): wherein R5 is selected from the group consisting of 3-pyridyl, 5-pyrimidinyl, -CONH-(C1-C4 alkyl), -NHCO-(C1-C4 alkyl), halogen, -SO2NH2, -NO2, -CF3 or thien-2-ylcarbonyl and -CO2R where R can be hydrogen or C1-C4 alkyl; and Ar is selected from the group consisting of 5-imidazolyl, 2-pyrrolyl optionally substituted by a C1-C4 alkyl radical, 2-furyl or 2-thiazolyl, in the E or Z geometrical isomeric form or a mixture of the two geometrical isomeric forms. The invention is also directed to a method of treating primary and secondary tumours in a patient in need thereof comprising administering to the patient a therapeutically effective amount of a compound of formula I. The invention is also directed to a method of using a compound of formula I to treat cancer, inhibit the proliferation of a cell and induce cell apoptosis, comprising contacting a cell with an effective amount of the compound of formula I., The invention is also directed to a method of preparing the compound of formula I.</description><subject>CHEMISTRY</subject><subject>HETEROCYCLIC COMPOUNDS</subject><subject>HUMAN NECESSITIES</subject><subject>HYGIENE</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>ORGANIC CHEMISTRY</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2005</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZLDxr8jMS8nPSS1SKM7PVXB28dY11M3My8hMyizJLwKK5qcrpKQWpRYrJOaVpealpOYUpypkKpSkFiUWZPIwsKYlAgV4oTQ3g6Kba4izh25qQX58anFBYnJqXmpJvIu3obGZmYGxRUiIsTExagCLPS9k</recordid><startdate>20051219</startdate><enddate>20051219</enddate><creator>MARATRAT, MICHEL</creator><creator>GRONDARD, LUCILE</creator><creator>LAVAYRE, JACQUES</creator><creator>MAILLIET, PATRICK</creator><creator>THOMPSON, FABIENNE</creator><creator>RIOU, JEAN-FRANCOIS</creator><creator>PETITGENET, ODILE</creator><scope>EVB</scope></search><sort><creationdate>20051219</creationdate><title>Oxindoler som CDK-1-inhibitorer og deres anvendelse i terapi</title><author>MARATRAT, MICHEL ; GRONDARD, LUCILE ; LAVAYRE, JACQUES ; MAILLIET, PATRICK ; THOMPSON, FABIENNE ; RIOU, JEAN-FRANCOIS ; PETITGENET, ODILE</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_DK1366038TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>dan</language><creationdate>2005</creationdate><topic>CHEMISTRY</topic><topic>HETEROCYCLIC COMPOUNDS</topic><topic>HUMAN NECESSITIES</topic><topic>HYGIENE</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>ORGANIC CHEMISTRY</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><toplevel>online_resources</toplevel><creatorcontrib>MARATRAT, MICHEL</creatorcontrib><creatorcontrib>GRONDARD, LUCILE</creatorcontrib><creatorcontrib>LAVAYRE, JACQUES</creatorcontrib><creatorcontrib>MAILLIET, PATRICK</creatorcontrib><creatorcontrib>THOMPSON, FABIENNE</creatorcontrib><creatorcontrib>RIOU, JEAN-FRANCOIS</creatorcontrib><creatorcontrib>PETITGENET, ODILE</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>MARATRAT, MICHEL</au><au>GRONDARD, LUCILE</au><au>LAVAYRE, JACQUES</au><au>MAILLIET, PATRICK</au><au>THOMPSON, FABIENNE</au><au>RIOU, JEAN-FRANCOIS</au><au>PETITGENET, ODILE</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Oxindoler som CDK-1-inhibitorer og deres anvendelse i terapi</title><date>2005-12-19</date><risdate>2005</risdate><abstract>The present invention relates to a compound of formula (I): wherein R5 is selected from the group consisting of 3-pyridyl, 5-pyrimidinyl, -CONH-(C1-C4 alkyl), -NHCO-(C1-C4 alkyl), halogen, -SO2NH2, -NO2, -CF3 or thien-2-ylcarbonyl and -CO2R where R can be hydrogen or C1-C4 alkyl; and Ar is selected from the group consisting of 5-imidazolyl, 2-pyrrolyl optionally substituted by a C1-C4 alkyl radical, 2-furyl or 2-thiazolyl, in the E or Z geometrical isomeric form or a mixture of the two geometrical isomeric forms. The invention is also directed to a method of treating primary and secondary tumours in a patient in need thereof comprising administering to the patient a therapeutically effective amount of a compound of formula I. The invention is also directed to a method of using a compound of formula I to treat cancer, inhibit the proliferation of a cell and induce cell apoptosis, comprising contacting a cell with an effective amount of the compound of formula I., The invention is also directed to a method of preparing the compound of formula I.</abstract><edition>7</edition><oa>free_for_read</oa></addata></record> |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Oxindoler som CDK-1-inhibitorer og deres anvendelse i terapi |
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