Tværbundet stivelse med höjt amyloseindhold til anvendelse i farmaceutiske formuleringer med reguleret frigivelse og fremgangsmåder til dens fremstilling

The present invention relates to a novel form of cross-linked high amylose starch and processes for its manufacture. Such cross-linked high amylose starch is useful as an excipient in a controlled-release pharmaceutical formulation when compressed with pharmaceutical agent(s) in a tablet. Such cross...

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Hauptverfasser: HOPCKE, REINER, BECK, ROLAND HERWIG FRIEDRICH, BOGAERT, ELSIE VAN, LENAERTS, VINCENT, CHOUINARD, FRANCOIS, DESEVAUX, CYRIL
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creator HOPCKE, REINER
BECK, ROLAND HERWIG FRIEDRICH
BOGAERT, ELSIE VAN
LENAERTS, VINCENT
CHOUINARD, FRANCOIS
DESEVAUX, CYRIL
description The present invention relates to a novel form of cross-linked high amylose starch and processes for its manufacture. Such cross-linked high amylose starch is useful as an excipient in a controlled-release pharmaceutical formulation when compressed with pharmaceutical agent(s) in a tablet. Such cross-linked high amylose starch is prepared by (a) cross-linking and chemical modification of high amylose starch, (b) gelatinization, and (c) drying to obtain a powder of said controlled release excipient. In a preferred embodiment, such cross-linked high amylose starch is prepared in the following steps: (1) granular cross-linking and additional chemical modification (e.g., hydroxypropylation) of high-amylose starch; (2) thermal gelatinization of the starch from step (1); and (3) drying the starch from step (2) to yield a powder capable of being used as a controlled release excipient.
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subjects CHEMISTRY
COMPOSITIONS BASED THEREON
DERIVATIVES THEREOF
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC MACROMOLECULAR COMPOUNDS
POLYSACCHARIDES
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
THEIR PREPARATION OR CHEMICAL WORKING-UP
title Tværbundet stivelse med höjt amyloseindhold til anvendelse i farmaceutiske formuleringer med reguleret frigivelse og fremgangsmåder til dens fremstilling
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