Fremgangsmåde til fremstilling af 3,5-bis-(trifluormethyl)-benzoylchlorider og nye 3,5-bis-(trihalogenmethyl)- og 3,5-dimethyl-benzoylhalogenider

Fremgangsmåde til fremstilling af 3,5-bis-(trifluormethyl)-benzoylchlorider og nye 3,5-bis-(trihalogenmethyl)- og 3,5-dimethyl-benzoylhalogenider

Preparation of 3,5-bis-(trifluoromethyl)-benzoyl chlorides (I) involves converting a 3,5-dimethyl-benzoic acid (V) into the acid chloride (IV), subjecting the side-chains to radical chlorination, fluorinating with anhydrous hydrogen fluoride and/or antimony pentafluoride to give a 3,5-bis-(trifluoro...

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Hauptverfasser: MARHOLD, ALBRECHT, STOELTING, JOERN
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
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STOELTING, JOERN
description Preparation of 3,5-bis-(trifluoromethyl)-benzoyl chlorides (I) involves converting a 3,5-dimethyl-benzoic acid (V) into the acid chloride (IV), subjecting the side-chains to radical chlorination, fluorinating with anhydrous hydrogen fluoride and/or antimony pentafluoride to give a 3,5-bis-(trifluoromethyl)-benzoyl fluoride and reacting with silicon tetrachloride in presence of another Lewis acid. Preparation of 3,5-bis-(trifluoromethyl)-benzoyl chlorides of formula (I) involves: (1) converting a 3,5-dimethyl-benzoic acid of formula (V) into the corresponding acid chloride of formula (IV); (2) subjecting the side-chains to complete radical chlorination to give a 3,5-bis-(trichloromethyl)-benzoyl chloride of formula (III); (3) fluorinating with anhydrous hydrogen fluoride and/or antimony pentafluoride to give a 3,5-bis-(trifluoromethyl)-benzoyl fluoride of formula (II); and (4) reacting with silicon tetrachloride in presence of another Lewis acid. [Image] X : H, F or Cl. Independent claims are included for the intermediates (III; X = F or Cl) and (IV; X = F or Cl) as new compounds.
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Preparation of 3,5-bis-(trifluoromethyl)-benzoyl chlorides of formula (I) involves: (1) converting a 3,5-dimethyl-benzoic acid of formula (V) into the corresponding acid chloride of formula (IV); (2) subjecting the side-chains to complete radical chlorination to give a 3,5-bis-(trichloromethyl)-benzoyl chloride of formula (III); (3) fluorinating with anhydrous hydrogen fluoride and/or antimony pentafluoride to give a 3,5-bis-(trifluoromethyl)-benzoyl fluoride of formula (II); and (4) reacting with silicon tetrachloride in presence of another Lewis acid. [Image] X : H, F or Cl. 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subjects ACYCLIC OR CARBOCYCLIC COMPOUNDS
APPARATUS THEREFOR
CHEMISTRY
GENERAL METHODS OF ORGANIC CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
title Fremgangsmåde til fremstilling af 3,5-bis-(trifluormethyl)-benzoylchlorider og nye 3,5-bis-(trihalogenmethyl)- og 3,5-dimethyl-benzoylhalogenider
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