Ny fremgangsmåde til fremstilling af (+/-)3-(3,4-dichlorophenyl)-2-dimethylamino-2-methylpropan-1-ol eller cericlamin (INN)

Ny fremgangsmåde til fremstilling af (+/-)3-(3,4-dichlorophenyl)-2-dimethylamino-2-methylpropan-1-ol eller cericlamin (INN)

PCT No. PCT/EP98/02213 Sec. 371 Date Dec. 20, 1999 Sec. 102(e) Date Dec. 20, 1999 PCT Filed Apr. 6, 1998 PCT Pub. No. WO98/45248 PCT Pub. Date Oct. 15, 1998Process for the preparation of cericlamine which consists: i) in arylating methacrylic acid with the diazonium chloride of 3,4-dichloroaniline,...

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Hauptverfasser: LABOUE, BLANDINE, DEPERNET, DOMINIQUE, NICOLAS, MARC
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ACYCLIC OR CARBOCYCLIC COMPOUNDS
CHEMISTRY
METALLURGY
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DEPERNET, DOMINIQUE
NICOLAS, MARC
description PCT No. PCT/EP98/02213 Sec. 371 Date Dec. 20, 1999 Sec. 102(e) Date Dec. 20, 1999 PCT Filed Apr. 6, 1998 PCT Pub. No. WO98/45248 PCT Pub. Date Oct. 15, 1998Process for the preparation of cericlamine which consists: i) in arylating methacrylic acid with the diazonium chloride of 3,4-dichloroaniline, to obtain (+/-)2-chloro-3-(3,4-dichlorophenyl)-2-methylpropionic acid, ii) in aminating the acid with dimethylamine, to obtain (+/-)3-(3,4-dichlorophenyl)-2-dimethylamino-2-methylpropionic acid, or an alkaline metal salt thereof, iii) in esterifying the amino-acid or its salt, then, iv) in reducing the ester by a metal or organometal hydride to obtain (+/-)3-(3,4-dichlorophenyl)-2-dimethylamino-2-methyl-propan-1-ol.
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CHEMISTRY
METALLURGY
ORGANIC CHEMISTRY
title Ny fremgangsmåde til fremstilling af (+/-)3-(3,4-dichlorophenyl)-2-dimethylamino-2-methylpropan-1-ol eller cericlamin (INN)
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