Piperazin-2,5-dionderivater som modulatorer af multiresistens

Piperazin-2,5-dionderivater som modulatorer af multiresistens

PCT No. PCT/GB95/03029 Sec. 371 Date Aug. 29, 1997 Sec. 102(e) Date Aug. 29, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/20180 PCT Pub. Date Jul. 4, 1996A piperazinedione of general formula (I): wherein R1 is selected from hydrogen; a group of formula -(NH)t-COR3 wherein t is 0 or 1 and R3 is an...

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Hauptverfasser: BROCCHINI, STEPHEN, JAMES, ASHWORTH, PHILIP, ANTHONY, HUNJAN, SUKHJIT, PRETSWELL, IAN, ANDREW, RYDER, HAMISH
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CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
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creator BROCCHINI, STEPHEN, JAMES
ASHWORTH, PHILIP, ANTHONY
HUNJAN, SUKHJIT
PRETSWELL, IAN, ANDREW
RYDER, HAMISH
description PCT No. PCT/GB95/03029 Sec. 371 Date Aug. 29, 1997 Sec. 102(e) Date Aug. 29, 1997 PCT Filed Dec. 22, 1995 PCT Pub. No. WO96/20180 PCT Pub. Date Jul. 4, 1996A piperazinedione of general formula (I): wherein R1 is selected from hydrogen; a group of formula -(NH)t-COR3 wherein t is 0 or 1 and R3 is an organic substituent as defined herein; a group of formula (D): and a group of formula (E): and the pharmaceutically acceptable salts thereof are useful as modulators of multi-drug resistance.
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subjects CHEMISTRY
HETEROCYCLIC COMPOUNDS
HUMAN NECESSITIES
HYGIENE
MEDICAL OR VETERINARY SCIENCE
METALLURGY
ORGANIC CHEMISTRY
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS
title Piperazin-2,5-dionderivater som modulatorer af multiresistens
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