Phosphononmoneosternukleinsyrer, fremgangsmåde til fremstilling deraf og anvendelse deraf
Oligonucleotide analogues and related cpds. of formula (I) are new, in which n = 0-100; B = H or OH; 1-20C alkyl, 1-20C alkoxy or 1-20C alkylthio opt. substd. by 6-20C aryl; or aryl or heterocyclyl; where alkyl, aryl and heterocyclyl are opt. substd.; or B = a natural or unnatural nucleobase or a la...
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| creator | ANUSCHIRWAN PEYMAN DR BREIPOHL GERHARD DR WALLMEIER, HOLGER UHLMANN, EUGEN |
| description | Oligonucleotide analogues and related cpds. of formula (I) are new, in which n = 0-100; B = H or OH; 1-20C alkyl, 1-20C alkoxy or 1-20C alkylthio opt. substd. by 6-20C aryl; or aryl or heterocyclyl; where alkyl, aryl and heterocyclyl are opt. substd.; or B = a natural or unnatural nucleobase or a label; A = a single bond, CH2, (CR R )pM(CR R )q or (CR R )rM(CR R )sCY'; or A-B = 1-5 D- or L-amino acids condensed on via the carboxyl group; L = N or R N; R = H or 1-6C alkyl opt. substd. by OH, 1-6C alkoxy, 1-6C alkylthio or NH2; Y' = O, S, CH2, CMe2 or NR ; M = a single bond, O, S or NR ; R and R = H, OH, 1-6C alkoxy, 1-6C alkylthio, NH2, halogen, or 1-6C alkyl opt. substd. by OH, 1-6C alkoxy or 1-6C alkylthio; p, q, r and s = 0-5; D and G = CR R ; R and R = H, 1-6C alkyl, 6-20C aryl, (6-20C)aryl(1-6C)alkyl, OH, 1-6C alkoxy or 1-6C alkylthio, where alkyl and aryl are opt. substd. by SR or NR R ; X = O, S or NR ; Y = O or S; Z = OR , NR R or XQ; R = H, alkyl, alkenyl, alkynyl, aryl or arylalkyl, where alkyl and aryl are opt. substd.; R and R = H, alkyl, alkenyl, alkynyl, aryl or arylalkyl, where alkyl is opt. substd.; or NR R is a 4- to 7-membered ring; Q and Q' = H, R , opt. modified oligonucleotides or conjugates which (a) favourably affect the properties of antisense oligonucleotides, (b) affect the properties of triplex-forming oligonucleotides, (c) serve as DNA probe labels or (d) bind to or crosslink a target nucleic acid during hybridisation; or Q and Q' alone or together are a single bond in a cyclic molecule; or Q and Q', when neither is hydrogen, can be linked together to form a cyclic molecule. |
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B = H or OH; 1-20C alkyl, 1-20C alkoxy or 1-20C alkylthio opt. substd. by 6-20C aryl; or aryl or heterocyclyl; where alkyl, aryl and heterocyclyl are opt. substd.; or B = a natural or unnatural nucleobase or a label; A = a single bond, CH2, (CR R )pM(CR R )q or (CR R )rM(CR R )sCY'; or A-B = 1-5 D- or L-amino acids condensed on via the carboxyl group; L = N or R N<+>; R = H or 1-6C alkyl opt. substd. by OH, 1-6C alkoxy, 1-6C alkylthio or NH2; Y' = O, S, CH2, CMe2 or NR ; M = a single bond, O, S or NR ; R and R = H, OH, 1-6C alkoxy, 1-6C alkylthio, NH2, halogen, or 1-6C alkyl opt. substd. by OH, 1-6C alkoxy or 1-6C alkylthio; p, q, r and s = 0-5; D and G = CR R ; R and R = H, 1-6C alkyl, 6-20C aryl, (6-20C)aryl(1-6C)alkyl, OH, 1-6C alkoxy or 1-6C alkylthio, where alkyl and aryl are opt. substd. by SR or NR R ; X = O, S or NR ; Y = O or S; Z = OR , NR R or XQ; R = H, alkyl, alkenyl, alkynyl, aryl or arylalkyl, where alkyl and aryl are opt. substd.; R and R = H, alkyl, alkenyl, alkynyl, aryl or arylalkyl, where alkyl is opt. substd.; or NR R is a 4- to 7-membered ring; Q and Q' = H, R , opt. modified oligonucleotides or conjugates which (a) favourably affect the properties of antisense oligonucleotides, (b) affect the properties of triplex-forming oligonucleotides, (c) serve as DNA probe labels or (d) bind to or crosslink a target nucleic acid during hybridisation; or Q and Q' alone or together are a single bond in a cyclic molecule; or Q and Q', when neither is hydrogen, can be linked together to form a cyclic molecule.</description><edition>6</edition><language>dan</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; AGRICULTURE ; ANIMAL HUSBANDRY ; BEER ; BIOCHEMISTRY ; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES ; CHEMISTRY ; COMPOSITIONS OR TEST PAPERS THEREFOR ; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES ; DERIVATIVES THEREOF ; ENZYMOLOGY ; FISHING ; 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B = H or OH; 1-20C alkyl, 1-20C alkoxy or 1-20C alkylthio opt. substd. by 6-20C aryl; or aryl or heterocyclyl; where alkyl, aryl and heterocyclyl are opt. substd.; or B = a natural or unnatural nucleobase or a label; A = a single bond, CH2, (CR R )pM(CR R )q or (CR R )rM(CR R )sCY'; or A-B = 1-5 D- or L-amino acids condensed on via the carboxyl group; L = N or R N<+>; R = H or 1-6C alkyl opt. substd. by OH, 1-6C alkoxy, 1-6C alkylthio or NH2; Y' = O, S, CH2, CMe2 or NR ; M = a single bond, O, S or NR ; R and R = H, OH, 1-6C alkoxy, 1-6C alkylthio, NH2, halogen, or 1-6C alkyl opt. substd. by OH, 1-6C alkoxy or 1-6C alkylthio; p, q, r and s = 0-5; D and G = CR R ; R and R = H, 1-6C alkyl, 6-20C aryl, (6-20C)aryl(1-6C)alkyl, OH, 1-6C alkoxy or 1-6C alkylthio, where alkyl and aryl are opt. substd. by SR or NR R ; X = O, S or NR ; Y = O or S; Z = OR , NR R or XQ; R = H, alkyl, alkenyl, alkynyl, aryl or arylalkyl, where alkyl and aryl are opt. substd.; R and R = H, alkyl, alkenyl, alkynyl, aryl or arylalkyl, where alkyl is opt. substd.; or NR R is a 4- to 7-membered ring; Q and Q' = H, R , opt. modified oligonucleotides or conjugates which (a) favourably affect the properties of antisense oligonucleotides, (b) affect the properties of triplex-forming oligonucleotides, (c) serve as DNA probe labels or (d) bind to or crosslink a target nucleic acid during hybridisation; or Q and Q' alone or together are a single bond in a cyclic molecule; or Q and Q', when neither is hydrogen, can be linked together to form a cyclic molecule.</description><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</subject><subject>AGRICULTURE</subject><subject>ANIMAL HUSBANDRY</subject><subject>BEER</subject><subject>BIOCHEMISTRY</subject><subject>BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES</subject><subject>CHEMISTRY</subject><subject>COMPOSITIONS OR TEST PAPERS THEREFOR</subject><subject>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</subject><subject>DERIVATIVES THEREOF</subject><subject>ENZYMOLOGY</subject><subject>FISHING</subject><subject>FORESTRY</subject><subject>HUMAN NECESSITIES</subject><subject>HUNTING</subject><subject>HYGIENE</subject><subject>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</subject><subject>MEDICAL OR VETERINARY SCIENCE</subject><subject>METALLURGY</subject><subject>MICROBIOLOGY</subject><subject>MUTATION OR GENETIC ENGINEERING</subject><subject>NUCLEIC ACIDS</subject><subject>NUCLEOSIDES</subject><subject>NUCLEOTIDES</subject><subject>ORGANIC CHEMISTRY</subject><subject>PEPTIDES</subject><subject>PEST REPELLANTS OR ATTRACTANTS</subject><subject>PLANT GROWTH REGULATORS</subject><subject>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</subject><subject>PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF</subject><subject>PROCESSES OF PREPARING SUCH COMPOSITIONS</subject><subject>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</subject><subject>SPIRITS</subject><subject>SUGARS</subject><subject>TRAPPING</subject><subject>VINEGAR</subject><subject>WINE</subject><fulltext>true</fulltext><rsrctype>patent</rsrctype><creationdate>2001</creationdate><recordtype>patent</recordtype><sourceid>EVB</sourceid><recordid>eNrjZIgKyMgvLsjIz8vPy83PS80vLkktyivNzknNzCuuLEot0lFIK0rNTU_MSy_OPbw0JVWhJDMHLFQMZORk5qUrpKQWJaYp5KcrJOaVpealpOYUp0LEeBhY0xKBPF4ozc2g6OYa4uyhm1qQH59aXJCYnJqXWhLv4m1gbmxpYWkREmJsTIwaAHs9Pbg</recordid><startdate>20011210</startdate><enddate>20011210</enddate><creator>ANUSCHIRWAN PEYMAN DR</creator><creator>BREIPOHL GERHARD DR</creator><creator>WALLMEIER, HOLGER</creator><creator>UHLMANN, EUGEN</creator><scope>EVB</scope></search><sort><creationdate>20011210</creationdate><title>Phosphononmoneosternukleinsyrer, fremgangsmåde til fremstilling deraf og anvendelse deraf</title><author>ANUSCHIRWAN PEYMAN DR ; BREIPOHL GERHARD DR ; WALLMEIER, HOLGER ; UHLMANN, EUGEN</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-epo_espacenet_DK0739898TT33</frbrgroupid><rsrctype>patents</rsrctype><prefilter>patents</prefilter><language>dan</language><creationdate>2001</creationdate><topic>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM</topic><topic>AGRICULTURE</topic><topic>ANIMAL HUSBANDRY</topic><topic>BEER</topic><topic>BIOCHEMISTRY</topic><topic>BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES</topic><topic>CHEMISTRY</topic><topic>COMPOSITIONS OR TEST PAPERS THEREFOR</topic><topic>CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES</topic><topic>DERIVATIVES THEREOF</topic><topic>ENZYMOLOGY</topic><topic>FISHING</topic><topic>FORESTRY</topic><topic>HUMAN NECESSITIES</topic><topic>HUNTING</topic><topic>HYGIENE</topic><topic>MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS</topic><topic>MEDICAL OR VETERINARY SCIENCE</topic><topic>METALLURGY</topic><topic>MICROBIOLOGY</topic><topic>MUTATION OR GENETIC ENGINEERING</topic><topic>NUCLEIC ACIDS</topic><topic>NUCLEOSIDES</topic><topic>NUCLEOTIDES</topic><topic>ORGANIC CHEMISTRY</topic><topic>PEPTIDES</topic><topic>PEST REPELLANTS OR ATTRACTANTS</topic><topic>PLANT GROWTH REGULATORS</topic><topic>PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES</topic><topic>PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF</topic><topic>PROCESSES OF PREPARING SUCH COMPOSITIONS</topic><topic>SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS</topic><topic>SPIRITS</topic><topic>SUGARS</topic><topic>TRAPPING</topic><topic>VINEGAR</topic><topic>WINE</topic><toplevel>online_resources</toplevel><creatorcontrib>ANUSCHIRWAN PEYMAN DR</creatorcontrib><creatorcontrib>BREIPOHL GERHARD DR</creatorcontrib><creatorcontrib>WALLMEIER, HOLGER</creatorcontrib><creatorcontrib>UHLMANN, EUGEN</creatorcontrib><collection>esp@cenet</collection></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>ANUSCHIRWAN PEYMAN DR</au><au>BREIPOHL GERHARD DR</au><au>WALLMEIER, HOLGER</au><au>UHLMANN, EUGEN</au><format>patent</format><genre>patent</genre><ristype>GEN</ristype><title>Phosphononmoneosternukleinsyrer, fremgangsmåde til fremstilling deraf og anvendelse deraf</title><date>2001-12-10</date><risdate>2001</risdate><abstract>Oligonucleotide analogues and related cpds. of formula (I) are new, in which n = 0-100; B = H or OH; 1-20C alkyl, 1-20C alkoxy or 1-20C alkylthio opt. substd. by 6-20C aryl; or aryl or heterocyclyl; where alkyl, aryl and heterocyclyl are opt. substd.; or B = a natural or unnatural nucleobase or a label; A = a single bond, CH2, (CR R )pM(CR R )q or (CR R )rM(CR R )sCY'; or A-B = 1-5 D- or L-amino acids condensed on via the carboxyl group; L = N or R N<+>; R = H or 1-6C alkyl opt. substd. by OH, 1-6C alkoxy, 1-6C alkylthio or NH2; Y' = O, S, CH2, CMe2 or NR ; M = a single bond, O, S or NR ; R and R = H, OH, 1-6C alkoxy, 1-6C alkylthio, NH2, halogen, or 1-6C alkyl opt. substd. by OH, 1-6C alkoxy or 1-6C alkylthio; p, q, r and s = 0-5; D and G = CR R ; R and R = H, 1-6C alkyl, 6-20C aryl, (6-20C)aryl(1-6C)alkyl, OH, 1-6C alkoxy or 1-6C alkylthio, where alkyl and aryl are opt. substd. by SR or NR R ; X = O, S or NR ; Y = O or S; Z = OR , NR R or XQ; R = H, alkyl, alkenyl, alkynyl, aryl or arylalkyl, where alkyl and aryl are opt. substd.; R and R = H, alkyl, alkenyl, alkynyl, aryl or arylalkyl, where alkyl is opt. substd.; or NR R is a 4- to 7-membered ring; Q and Q' = H, R , opt. modified oligonucleotides or conjugates which (a) favourably affect the properties of antisense oligonucleotides, (b) affect the properties of triplex-forming oligonucleotides, (c) serve as DNA probe labels or (d) bind to or crosslink a target nucleic acid during hybridisation; or Q and Q' alone or together are a single bond in a cyclic molecule; or Q and Q', when neither is hydrogen, can be linked together to form a cyclic molecule.</abstract><edition>6</edition><oa>free_for_read</oa></addata></record> |
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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM AGRICULTURE ANIMAL HUSBANDRY BEER BIOCHEMISTRY BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES, AS HERBICIDES CHEMISTRY COMPOSITIONS OR TEST PAPERS THEREFOR CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL ORENZYMOLOGICAL PROCESSES DERIVATIVES THEREOF ENZYMOLOGY FISHING FORESTRY HUMAN NECESSITIES HUNTING HYGIENE MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEICACIDS OR MICROORGANISMS MEDICAL OR VETERINARY SCIENCE METALLURGY MICROBIOLOGY MUTATION OR GENETIC ENGINEERING NUCLEIC ACIDS NUCLEOSIDES NUCLEOTIDES ORGANIC CHEMISTRY PEPTIDES PEST REPELLANTS OR ATTRACTANTS PLANT GROWTH REGULATORS PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTSTHEREOF PROCESSES OF PREPARING SUCH COMPOSITIONS SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS SPIRITS SUGARS TRAPPING VINEGAR WINE |
| title | Phosphononmoneosternukleinsyrer, fremgangsmåde til fremstilling deraf og anvendelse deraf |
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