Fremgangsmåde til fremstilling af enantiomert rene 3-methyl-5-(1-alkyl-2(S)-pyrrolidinyl)isoxazoler
A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydra...
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| creator | BUNNELLE, WILLIAM, H WITZIG, CHRISTIAN, C LIN, NAN-HORNG ESCH, THOMAS, K., J NARAYANAN, BIKSHANDAR, A SINGAM, PULLA R ELLIOTT, RICHARD, L BEER, DIETER, O RAO, ALLA, V. RAMA, RESIDENCE OF DIRECTOR CHORGHADE, MUKUND, S HE, YUN HERZIG, THOMAS, C WITTENBERGER, STEVEN, J |
| description | A novel process for preparing enantiomerically-pure 3-methyl-5-(1-(C1-C3-alkyl)-2-pyrrolidinyl)isoxazole in high yield, wherein a protected pyrrolidine or 2-oxo-pyrrolidine starting material is reacted with a suitable organic anion and a resulting beta-keto oxime intermediate is cyclized and dehydrated, as well as intermediates useful in the preparation thereof. |
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| subjects | CHEMISTRY HETEROCYCLIC COMPOUNDS METALLURGY ORGANIC CHEMISTRY |
| title | Fremgangsmåde til fremstilling af enantiomert rene 3-methyl-5-(1-alkyl-2(S)-pyrrolidinyl)isoxazoler |
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