Mangankomplekser af nitrogenholdige, makrocykliske ligander effektive som katalysatorer til at dismutere superoxid
The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula:wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, R'10, R10 and R'10, X, Y, Z and...
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| creator | LENNON, PATRICK, JAMES MODAK, ANIL, SHRIKRISHNA RILEY, DENNIS, PATRICK ASTON, KARL, WILLIAM NEUMANN, WILLIAM, LOJDA WEISS, RANDY, HERMAN |
| description | The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula:wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, R'10, R10 and R'10, X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, myocardial infarction, stroke, atherosclerosis, and all other conditions of oxidant-induced tissue damage or injury. |
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MODAK, ANIL, SHRIKRISHNA ; RILEY, DENNIS, PATRICK ; ASTON, KARL, WILLIAM ; NEUMANN, WILLIAM, LOJDA ; WEISS, RANDY, HERMAN</creatorcontrib><description>The present invention is directed to low molecular weight mimics of superoxide dismutase (SOD) represented by the formula:wherein R, R', R1, R'1, R2, R'2, R3, R'3, R4, R'4, R5, R'5, R6, R'6, R7, R'7, R8, R'8, R9, R'10, R10 and R'10, X, Y, Z and n are as defined herein, useful as therapeutic agents for inflammatory disease states and disorders, ischemic/reperfusion injury, myocardial infarction, stroke, atherosclerosis, and all other conditions of oxidant-induced tissue damage or injury.</description><edition>6</edition><language>dan</language><subject>ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM ; CHEMISTRY ; HETEROCYCLIC COMPOUNDS ; HUMAN NECESSITIES ; HYGIENE ; MEDICAL OR VETERINARY SCIENCE ; METALLURGY ; ORGANIC CHEMISTRY ; PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES ; 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| subjects | ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAININGELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN,SULFUR, SELENIUM OR TELLURIUM CHEMISTRY HETEROCYCLIC COMPOUNDS HUMAN NECESSITIES HYGIENE MEDICAL OR VETERINARY SCIENCE METALLURGY ORGANIC CHEMISTRY PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS ORMEDICINAL PREPARATIONS |
| title | Mangankomplekser af nitrogenholdige, makrocykliske ligander effektive som katalysatorer til at dismutere superoxid |
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